Search Results - "Mak, Don‐On Daniel"

Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view by Mak, Don-On Daniel, Foskett, J. Kevin

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EMRE Is a Matrix Ca2+ Sensor that Governs Gatekeeping of the Mitochondrial Ca2+ Uniporter by Vais, Horia, Mallilankaraman, Karthik, Mak, Don-On Daniel, Hoff, Henry, Payne, Riley, Tanis, Jessica E., Foskett, J. Kevin

“…The mitochondrial uniporter (MCU) is an ion channel that mediates Ca2+ uptake into the matrix to regulate metabolism, cell death, and cytoplasmic Ca2+…”
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Data-driven modeling of mitochondrial dysfunction in Alzheimer's disease by Toglia, Patrick, Demuro, Angelo, Mak, Don-On Daniel, Ullah, Ghanim

“…•A simple four state model for IP3R, driven by extensive single channel patch-clamp experiments.•Estimating Ca2+ and IP3 from TIRF signals due to intracellular…”
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Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins by Mak, Don-On Daniel, Cheung, King-Ho, Toglia, Patrick, Foskett, J Kevin, Ullah, Ghanim

“…Familial Alzheimer's disease (FAD)-causing mutant presenilins (PS) interact with inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) Ca(2+) release channels…”
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A data-driven model of a modal gated ion channel: the inositol 1,4,5-trisphosphate receptor in insect Sf9 cells by Ullah, Ghanim, Mak, Don-On Daniel, Pearson, John E

“…The inositol 1,4,5-trisphosphate (IP(3)) receptor (IP(3)R) channel is crucial for the generation and modulation of intracellular Ca(2+) signals in animal…”
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Permeant calcium ion feed-through regulation of single inositol 1,4,5-trisphosphate receptor channel gating by Vais, Horia, Foskett, J Kevin, Ullah, Ghanim, Pearson, John E, Mak, Don-On Daniel

“…The ubiquitous inositol 1,4,5-trisphosphate (InsP(3)) receptor (InsP(3)R) Ca(2+) release channel plays a central role in the generation and modulation of…”
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ER-luminal [Ca2+] regulation of InsP3 receptor gating mediated by an ER-luminal peripheral Ca2+-binding protein by Vais, Horia, Wang, Min, Mallilankaraman, Karthik, Payne, Riley, McKennan, Chris, Lock, Jeffrey T, Spruce, Lynn A, Fiest, Carly, Chan, Matthew Yan-lok, Parker, Ian, Seeholzer, Steven H, Foskett, J Kevin, Mak, Don-On Daniel

“…Modulating cytoplasmic Ca2+ concentration ([Ca2+]i) by endoplasmic reticulum (ER)-localized inositol 1,4,5-trisphosphate receptor (InsP3R) Ca2+-release…”
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Regulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction by Raghuram, Viswanathan, Mak, Don-On Daniel, Foskett, J. Kevin

“…The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-dependent protein kinase- and ATP-regulated chloride channel, the activity of which…”
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Automated Maximum Likelihood Separation of Signal from Baseline in Noisy Quantal Data by Bruno, William J., Ullah, Ghanim, Daniel Mak, Don-On, Pearson, John E.

“…Data recordings often include high-frequency noise and baseline fluctuations that are not generated by the system under investigation, which need to be removed…”
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Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG by Mak, Don-On Daniel, Dang, Binh, Weiner, I David, Foskett, J Kevin, Westhoff, Connie M

“…The erythrocyte Rh-associated glycoprotein (RhAG) was recently found to mediate transport of ammonia/ammonium when expressed in Xenopus laevis oocytes and…”
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Identification of the Erythrocyte Rh Blood Group Glycoprotein as a Mammalian Ammonium Transporter by Westhoff, Connie M., Ferreri-Jacobia, Michelle, Mak, Don-On Daniel, Foskett, J. Kevin

“…The Rh blood group proteins are well known as the erythrocyte targets of the potent antibody response that causes hemolytic disease of the newborn. These…”
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Rapid ligand-regulated gating kinetics of single inositol 1,4,5-trisphosphate receptor Ca2+ release channels by Mak, Don-On Daniel, Pearson, John E, Loong, King Pan Campion, Datta, Suman, Fernández-Mongil, Marisabel, Foskett, J Kevin

“…The ubiquitous inositol 1,4,5‐trisphosphate receptor (InsP3R) intracellular Ca2+ release channel is engaged by thousands of plasma membrane receptors to…”
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MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival by Mallilankaraman, Karthik, Doonan, Patrick, Cárdenas, César, Chandramoorthy, Harish C, Müller, Marioly, Miller, Russell, Hoffman, Nicholas E, Gandhirajan, Rajesh Kumar, Molgó, Jordi, Birnbaum, Morris J, Rothberg, Brad S, Mak, Don-On Daniel, Foskett, J Kevin, Madesh, Muniswamy

“…Mitochondrial Ca(2+) (Ca(2+)(m)) uptake is mediated by an inner membrane Ca(2+) channel called the uniporter. Ca(2+) uptake is driven by the considerable…”
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EMRE Is a Matrix Ca(2+) Sensor that Governs Gatekeeping of the Mitochondrial Ca(2+) Uniporter by Vais, Horia, Mallilankaraman, Karthik, Mak, Don-On Daniel, Hoff, Henry, Payne, Riley, Tanis, Jessica E, Foskett, J Kevin

“…The mitochondrial uniporter (MCU) is an ion channel that mediates Ca(2+) uptake into the matrix to regulate metabolism, cell death, and cytoplasmic Ca(2+)…”
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Inositol Trisphosphate Receptor Ca2+ Release Channels by Foskett, J. Kevin, White, Carl, Cheung, King-Ho, Mak, Don-On Daniel

“…Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania The inositol 1,4,5-trisphosphate (InsP 3 ) receptors (InsP 3 Rs) are a family…”
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Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quartal Ca2+release by Ionescu, Lucian, Cheung, King‐Ho, Vais, Horia, Mak, Don‐On Daniel, White, Carl, Foskett, J. Kevin

“…Modulation of cytoplasmic free Ca 2 + concentration ([Ca 2 + ] i ) by receptor-mediated generation of inositol 1,4,5-trisphosphate (InsP 3 ) and activation of…”
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MICU1 Is an Essential Gatekeeper for MCU-Mediated Mitochondrial Ca2+ Uptake that Regulates Cell Survival by Mallilankaraman, Karthik, Doonan, Patrick, Cárdenas, César, Chandramoorthy, Harish C., Müller, Marioly, Miller, Russell, Hoffman, Nicholas E., Gandhirajan, Rajesh Kumar, Molgó, Jordi, Birnbaum, Morris J., Rothberg, Brad S., Mak, Don-On Daniel, Foskett, J. Kevin, Madesh, Muniswamy

“…Mitochondrial Ca2+ (Ca2+m) uptake is mediated by an inner membrane Ca2+ channel called the uniporter. Ca2+ uptake is driven by the considerable voltage present…”
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Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons by Cheung, King-Ho, Mei, Lijuan, Mak, Don-On Daniel, Hayashi, Ikuo, Iwatsubo, Takeshi, Kang, David E, Foskett, J Kevin

“…Familial Alzheimer's disease (FAD) is caused by mutations in amyloid precursor protein or presenilins (PS1 and PS2). Many FAD-linked PS mutations affect…”
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Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca(2+) disruptions by Toglia, Patrick, Cheung, King-Ho, Mak, Don-On Daniel, Ullah, Ghanim

“…Mutants in presenilins (PS1 or PS2) is the major cause of familial Alzheimer's disease (FAD). FAD causing PS mutants affect intracellular Ca(2+) homeostasis by…”
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Spontaneous channel activity of the inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Application of allosteric modeling to calcium and InsP3 regulation of InsP3R single-channel gating by Mak, Don-On Daniel, McBride, Sean M J, Foskett, J Kevin

“…The InsP3R Ca2+ release channel has a biphasic dependence on cytoplasmic free Ca2+ concentration ([Ca2+]i). InsP3 activates gating primarily by reducing the…”
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