Search Results - "Majuta, Lisa"

The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur by Chartier, Stephane R., Mitchell, Stefanie A.T., Majuta, Lisa A., Mantyh, Patrick W.

“…•There is a rich sensory and sympathetic innervation in the young bone.•With aging, there is a greater decline in sympathetic rather than sensory nerve…”
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New Insights in Understanding and Treating Bone Fracture Pain by Mitchell, Stefanie A. T., Majuta, Lisa A., Mantyh, Patrick W.

“…Purpose of Review This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new…”
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Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain by Guedon, Jean-Marc G., Longo, Geraldine, Majuta, Lisa A., Thomspon, Michelle L., Fealk, Michelle N., Mantyh, Patrick W.

“…Recent studies have suggested that in humans and animals with significant skeletal pain, changes in the mechanical hypersensitivity of the skin can be…”
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Orthopedic surgery and bone fracture pain are both significantly attenuated by sustained blockade of nerve growth factor by Majuta, Lisa A., Longo, Geraldine, Fealk, Michelle N., McCaffrey, Gwen, Mantyh, Patrick W.

“…The number of patients suffering from postoperative pain due to orthopedic surgery and bone fracture is projected to dramatically increase because the human…”
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Exuberant sprouting of sensory and sympathetic nerve fibers in nonhealed bone fractures and the generation and maintenance of chronic skeletal pain by Chartier, Stephane R., Thompson, Michelle L., Longo, Geraldine, Fealk, Michelle N., Majuta, Lisa A., Mantyh, Patrick W.

“…Characterizing the ectopic sensory and sympathetic nerve growth that occurs in nonhealed fractures may provide insight into the mechanisms that drive chronic…”
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Anti–nerve growth factor does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain by Majuta, Lisa A., Mitchell, Stefanie A.T., Kuskowski, Michael A., Mantyh, Patrick W.

“…Anti-nerve growth factor (anti-NGF) therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy…”
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NGF blockade at early times during bone cancer development attenuates bone destruction and increases limb use by McCaffrey, Gwen, Thompson, Michelle L, Majuta, Lisa, Fealk, Michelle N, Chartier, Stephane, Longo, Geraldine, Mantyh, Patrick W

“…Studies in animals and humans show that blockade of nerve growth factor (NGF) attenuates both malignant and nonmalignant skeletal pain. While reduction of pain…”
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Anti–nerve growth factor therapy increases spontaneous day/night activity in mice with orthopedic surgery–induced pain by Majuta, Lisa A., Guedon, Jean-Marc G., Mitchell, Stefanie A.T., Ossipov, Michael H., Mantyh, Patrick W.

“…Total knee arthroplasty (TKA) and total hip arthroplasty (THA) are 2 of the most common and successful surgical interventions to relieve osteoarthritis pain…”
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Immunohistochemical localization of nerve growth factor, tropomyosin receptor kinase A, and p75 in the bone and articular cartilage of the mouse femur by Chartier, Stephane R, Mitchell, Stefanie AT, Majuta, Lisa A, Mantyh, Patrick W

“…Sequestration of nerve growth factor (NGF) significantly attenuates skeletal pain in both animals and humans. However, relatively little is known about the…”
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Medullary pain facilitating neurons mediate allodynia in headache-related pain by Edelmayer, Rebecca M., Vanderah, Todd W., Majuta, Lisa, Zhang, En-Tan, Fioravanti, Beatriz, De Felice, Milena, Chichorro, Juliana G., Ossipov, Michael H., King, Tamara, Lai, Josephine, Kori, Shashi H., Nelsen, Andrew C., Cannon, Keri E., Heinricher, Mary M., Porreca, Frank

“…Objective To develop and validate a model of cutaneous allodynia triggered by dural inflammation for pain associated with headaches. To explore neural…”
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Morphine treatment accelerates sarcoma-induced bone pain, bone loss, and spontaneous fracture in a murine model of bone cancer by King, Tamara, Vardanyan, Anna, Majuta, Lisa, Melemedjian, Ohannes, Nagle, Ray, Cress, Anne E., Vanderah, Todd W., Lai, Josephine, Porreca, Frank

“…Metastatic bone cancer causes severe pain that is primarily treated with opioids. A model of bone cancer pain in which the progression of cancer pain and bone…”
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Mice with cancer-induced bone pain show a marked decline in day/night activity by Majuta, Lisa A., Guedon, Jean-Marc G., Mitchell, Stefanie A.T., Kuskowski, Michael A., Mantyh, Patrick W.

“…Cancer-induced bone pain (CIBP) is the most common type of pain with cancer. In humans, this pain can be difficult to control and highly disabling. A major…”
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The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model by King, Tamara E, Pawar, Sangita C, Majuta, Lisa, Sroka, Isis C, Wynn, Danyel, Demetriou, Manolis C, Nagle, Raymond B, Porreca, Frank, Cress, Anne E

“…Of the estimated 565,650 people in the U.S. who will die of cancer in 2008, almost all will have metastasis. Breast, prostate, kidney, thyroid and lung cancers…”
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Anti-NGF does not change physical activity in normal young or aging mice but does increase activity in mice with skeletal pain by Majuta, Lisa A., Mitchell, Stefanie A.T., Kuskowski, Michael A., Mantyh, Patrick W.

“…Anti-NGF therapy has shown significant promise in attenuating several types of skeletal pain. However, whether anti-NGF therapy changes the level of physical…”
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K v 7 channel opener retigabine reduces self-administration of cocaine but not sucrose in rats by Urena, Esteban S, Diezel, Cody C, Serna, Mauricio, Hala'ufia, Grace, Majuta, Lisa, Barber, Kara R, Vanderah, Todd W, Riegel, Arthur C

“…The increasing rates of drug misuse highlight the urgency of identifying improved therapeutics for treatment. Most drug-seeking behaviours that can be modelled…”
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Kv7 channel opener retigabine reduces self‐administration of cocaine but not sucrose in rats by Urena, Esteban S., Diezel, Cody C., Serna, Mauricio, Hala'ufia, Grace, Majuta, Lisa, Barber, Kara R., Vanderah, Todd W., Riegel, Arthur C.

“…The increasing rates of drug misuse highlight the urgency of identifying improved therapeutics for treatment. Most drug‐seeking behaviours that can be modelled…”
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Targeting 5-HT2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model by Vizcarra, Velia S., Barber, Kara R., Franca-Solomon, Gabriela, Majuta, Lisa, Smith, Angela, Langlais, Paul R., Largent-Milnes, Tally M., Vanderah, Todd W., Riegel, Arthur C.

“…•5-HT2AR blockade in the PFC attenuated mechanical allodynia associated with SNI.•Enhancement of Kv7 activity in the PFC also attenuated mechanical…”
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Targeting 5-HT 2A receptors and Kv7 channels in PFC to attenuate chronic neuropathic pain in rats using a spared nerve injury model by Vizcarra, Velia S, Barber, Kara R, Franca-Solomon, Gabriela, Majuta, Lisa, Smith, Angela, Langlais, Paul R, Largent-Milnes, Tally M, Vanderah, Todd W, Riegel, Arthur C

“…Chronic pain remains a disabling disease with limited therapeutic options. Pyramidal neurons in the prefrontal cortex (PFC) express excitatory G -coupled 5-HT…”
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1,6-Disubstituted indole derivatives as selective human neuronal nitric oxide synthase inhibitors by Maddaford, Shawn, Renton, Paul, Speed, Joanne, Annedi, Subhash C., Ramnauth, Jailall, Rakhit, Suman, Andrews, John, Mladenova, Gabriela, Majuta, Lisa, Porreca, Frank

“…A series of 1,6-disubstituted indole derivatives was designed, synthesized and evaluated as inhibitors of human nitric oxide synthase (NOS). By varying the…”
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