Search Results - "Majumder, Hemanta K."

DNA Topoisomerases in Unicellular Pathogens: Structure, Function, and Druggability by Chowdhury, Somenath Roy, Majumder, Hemanta K.

“…All organisms, including unicellular pathogens, compulsorily possess DNA topoisomerases for successful nucleic acid metabolism. But particular subtypes of…”
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PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage by Das, Benu Brata, Huang, Shar-yin N, Murai, Junko, Rehman, Ishita, Amé, Jean-Christophe, Sengupta, Souvik, Das, Subhendu K, Majumdar, Papiya, Zhang, Hongliang, Biard, Denis, Majumder, Hemanta K, Schreiber, Valérie, Pommier, Yves

“…Poly(ADP-ribose) polymerases (PARP) attach poly(ADP-ribose) (PAR) chains to various proteins including themselves and chromatin. Topoisomerase I (Top1)…”
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The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice by Chowdhury, Sayan, Mukherjee, Tulika, Mukhopadhyay, Rupkatha, Mukherjee, Budhaditya, Sengupta, Souvik, Chattopadhyay, Sharmila, Jaisankar, Parasuraman, Roy, Syamal, Majumder, Hemanta K.

“…Niranthin, a lignan isolated from the aerial parts of the plant Phyllanthus amarus , exhibits a wide spectrum of pharmacological activities. In the present…”
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Development of derivatives of 3, 3'-diindolylmethane as potent Leishmania donovani bi-subunit topoisomerase IB poisons by Roy, Amit, Chowdhury, Sayan, Sengupta, Souvik, Mandal, Madhumita, Jaisankar, Parasuraman, D'Annessa, Ilda, Desideri, Alessandro, Majumder, Hemanta K

“…The development of 3, 3'-diindolyl methane (DIM) resistant parasite Leishmania donovani (LdDR50) by adaptation with increasing concentrations of the drug…”
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tyrosyl DNA phosphodiesterase 1 from kinetoplastid parasite Leishmania donovani (LdTdp1) capable of removing topo I-DNA covalent complexes by Banerjee, Bijoylaxmi, Roy, Amit, Sen, Nilkantha, Majumder, Hemanta K

“…Tyrosyl DNA phosphodiesterase 1 (Tdp1) is a member of phospholipase D superfamily, which cleaves a broad range of 3′-DNA adducts, the best characterized of…”
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Camptothecin-induced Imbalance in Intracellular Cation Homeostasis Regulates Programmed Cell Death in Unicellular Hemoflagellate Leishmania donovani by Sen, Nilkantha, Das, Benu Brata, Ganguly, Agneyo, Mukherjee, Tanmoy, Bandyopadhyay, Santu, Majumder, Hemanta K

“…Leishmania , a unicellular trypanosomatid protozoan parasite, causes a wide range of human diseases ranging from the localized self-healing cutaneous lesions…”
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Luteolin, an emerging anti-cancer flavonoid, poisons eukaryotic DNA topoisomerase I by Chowdhury, Arnab Roy, Sharma, Shalini, Mandal, Suparna, Goswami, Anindya, Mukhopadhyay, Sibabrata, Majumder, Hemanta K

“…Luteolin, a naturally occurring flavonoid, is abundant in our daily dietary intake. It exhibits a wide spectrum of pharmacological properties, but little is…”
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An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3'-di-indolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to the enzyme by Roy, Amit, Das, Benu Brata, Ganguly, Agneyo, Bose Dasgupta, Somdeb, Khalkho, Neeta V M, Pal, Churala, Dey, Sumit, Giri, Venkatachalam Sesha, Jaisankar, Parasuraman, Dey, Sanjit, Majumder, Hemanta K

“…DIM (3,3'-di-indolylmethane), an abundant dietary component of cruciferous vegetables, exhibits a wide spectrum of pharmacological properties. In the present…”
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Topoisomerase I Gene Mutations at F270 in the Large Subunit and N184 in the Small Subunit Contribute to the Resistance Mechanism of the Unicellular Parasite Leishmania donovani towards 3,3′-Diindolylmethane by ROY, Amit, BOSEDASGUPTA, Somdeb, GANGULY, Agneyo, JAISANKAR, Parasuraman, MAJUMDER, Hemanta K

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Retraction of ‘Functional dissection of the C‐terminal domain of type II DNA topoisomerase from the kinetoplastid hemoflagellate Leishmania donovani’ by Sengupta, Tanushri, Mukherjee, Mandira, Mandal, Chhabinath, Das, Aditi, Majumder, Hemanta K

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Type II DNA topoisomerases in trypanosomatid and apicomplexan parasites by Chowdhury, Somenath Roy, Bhoumik, Arpita, Gupta, Vivek Kumar, Majumder, Hemanta K.

“…•The distribution of type II topoisomerases in trypanosomatid and apicomplexan parasites is significantly diverse.•The two sub cellular organelles, apicoplast…”
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A Novel Spirooxindole Derivative Inhibits the Growth of Leishmania donovani Parasites both In Vitro and In Vivo by Targeting Type IB Topoisomerase by Saha, Sourav, Acharya, Chiranjit, Pal, Uttam, Chowdhury, Somenath Roy, Sarkar, Kahini, Maiti, Nakul C, Jaisankar, Parasuraman, Majumder, Hemanta K

“…Visceral leishmaniasis is a fatal parasitic disease, and there is an emergent need for development of effective drugs against this neglected tropical disease…”
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TDP1 knockout Leishmania donovani accumulate topoisomerase 1‐linked DNA damage and are hypersensitive to clinically used antileishmanial drugs by Chowdhury, Somenath Roy, Das, Subhendu K., Banerjee, Bijoylaxmi, Paul Chowdhuri, Srijita, Majumder, Hemanta K., Das, Benu Brata

“…Leishmania donovani, a unicellular protozoan parasite, causes a wide range of human diseases including fatal visceral leishmaniasis. Tyrosyl…”
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Amino acids 39-456 of the large subunit and 210-262 of the small subunit constitute the minimal functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania by Bosedasgupta, Somdeb, Das, Benu Brata, Sengupta, Souvik, Ganguly, Agneyo, Roy, Amit, Tripathi, Gayatri, Majumder, Hemanta K

“…The unusual, heterodimeric topoisomerase IB of Leishmania shows functional activity upon reconstitution of the DNA-binding large subunit (LdTOPIL; or L) and…”
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Mitochondria-dependent reactive oxygen species-mediated programmed cell death induced by 3,3'-diindolylmethane through inhibition of F0F1-ATP synthase in unicellular protozoan parasite Leishmania donovani by Roy, Amit, Ganguly, Agneyo, BoseDasgupta, Somdeb, Das, Benu Brata, Pal, Churala, Jaisankar, Parasuraman, Majumder, Hemanta K

“…Mitochondria are the principal site for the generation of cellular ATP by oxidative phosphorylation. F0F1-ATP synthase, a complex V of the electron transport…”
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N-terminal Region of the Large Subunit of Leishmania donovani Bisubunit Topoisomerase I Is Involved in DNA Relaxation and Interaction with the Smaller Subunit by Das, Benu Brata, Sen, Nilkantha, Dasgupta, Somdeb Bose, Ganguly, Agneyo, Majumder, Hemanta K.

“…Leishmania donovani topoisomerase I is an unusual bisubunit enzyme. We have demonstrated earlier that the large and small subunit could be reconstituted in…”
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Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani by Das, Rakhee, Roy, Amit, Dutta, Neeta, Majumder, Hemanta K

“…Curcumin, a polyphenol compound, has been recognized as a promising anti-cancer drug. The purpose of the present study was to investigate the cytotoxicity of…”
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Characterization of the ATPase activity of topoisomerase II from Leishmania donovani and identification of residues conferring resistance to etoposide by Sengupta, Tanushri, Mukherjee, Mandira, Das, Aditi, Mandal, Chhabinath, Das, Rakhee, Mukherjee, Tanmoy, Majumder, Hemanta K

“…We have cloned and expressed the 43 kDa N-terminal domain of Leishmania donovani topoisomerase II. This protein has an intrinsic ATPase activity and obeys…”
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Synthesis and Biological Evaluation of Calothrixins B and their Deoxygenated Analogues by Muthu Ramalingam, Bose, Dhatchana Moorthy, Nachiappan, Chowdhury, Somenath Roy, Mageshwaran, Thiyagarajan, Vellaichamy, Elangovan, Saha, Sourav, Ganesan, Karthikeyan, Rajesh, B. Navin, Iqbal, Saleem, Majumder, Hemanta K, Gunasekaran, Krishnasamy, Siva, Ramamoorthy, Mohanakrishnan, Arasambattu K

“…A series of calothrixin B (2) analogues bearing substituents at the ‘E’ ring and their corresponding deoxygenated quinocarbazoles lacking quinone unit were…”
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Copper salisylaldoxime (CuSAL) imparts protective efficacy against visceral leishmaniasis by targeting Leishmania donovani topoisomerase IB by Singh, Manoj Kumar, Bhaumik, Siddhartha Kumar, Karmakar, Subir, Paul, Joydeep, Sawoo, Sudeshna, Majumder, Hemanta K., Roy, Amit

“…In vitro and in vivo anti-leishmanial efficacy of copper salisylaldoxime (CuSAL), a transition metal complex, was evaluated and the underlying mechanism was…”
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