Search Results - "Majowicz, Anna"

Pre-existing humoral immunity and complement pathway contribute to immunogenicity of adeno-associated virus (AAV) vector in human blood by Smith, Corinne J., Ross, Nikki, Kamal, Ali, Kim, Kevin Y., Kropf, Elizabeth, Deschatelets, Pascal, Francois, Cedric, Quinn, William J., Singh, Inderpal, Majowicz, Anna, Mingozzi, Federico, Kuranda, Klaudia

“…AAV gene transfer is a promising treatment for many patients with life-threatening genetic diseases. However, host immune response to the vector poses a…”
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Successful Repeated Hepatic Gene Delivery in Mice and Non-human Primates Achieved by Sequential Administration of AAV5 ch and AAV1 by Majowicz, Anna, Salas, David, Zabaleta, Nerea, Rodríguez-Garcia, Estefania, González-Aseguinolaza, Gloria, Petry, Harald, Ferreira, Valerie

“…In the gene therapy field, re-administration of adeno-associated virus (AAV) is an important topic because a decrease in therapeutic protein expression might…”
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Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis by van der Marel, Sander, Majowicz, Anna, Kwikkers, Karin, van Logtenstein, Richard, te Velde, Anje A, De Groot, Anne S, Meijer, Sybren L, van Deventer, Sander J, Petry, Harald, Hommes, Daniel W, Ferreira, Valerie

“…AIM：To explore the anti-inflammatory potential of adeno-associated virus-mediated delivery of Tregitope 167 in an experimental colitis model.METHODS：The…”
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Murine CD4⁺CD25⁻ cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo by Majowicz, Anna, van der Marel, Sander, te Velde, Anje A, Meijer, Sybren L, Petry, Harald, van Deventer, Sander J, Ferreira, Valerie

“…Induced regulatory T (iTreg) lymphocytes show promise for application in the treatment of allergic, autoimmune and inflammatory disorders. iTreg cells…”
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Gene and cell therapy based treatment strategies for inflammatory bowel diseases by van der Marel, Sander, Majowicz, Anna, van Deventer, Sander, Petry, Harald, Hommes, Daniel W, Ferreira, Valerie

“…Inflammatory bowel diseases(IBD)are a group of chronic inflammatory disorders most commonly affecting young adults.Currently available therapies can result in…”
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701. Successful In Vivo Re-Administration of AAV with the Use of Two-Step AAV Injection by Majowicz, Anna, Petry, Harald, Ferreira, Valerie

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Therapeutic hFIX Activity Achieved after Single AAV5-hFIX Treatment in Hemophilia B Patients and NHPs with Pre-existing Anti-AAV5 NABs by Majowicz, Anna, Nijmeijer, Bart, Lampen, Margit H., Spronck, Lisa, de Haan, Martin, Petry, Harald, van Deventer, Sander J., Meyer, Christian, Tangelder, Marco, Ferreira, Valerie

“…Currently, individuals with pre-existing neutralizing antibodies (NABs) against adeno-associated virus (AAV) above titer of 5 are excluded from systemic…”
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THU-365-Adeno-associated virus-serotype-specific transduction patterns in mice and non-human primates liver tissue: Implications for therapeutic efficacy by Majowicz, Anna, Schwarz, Lukas, Laat, Johannes de, Deventer, Sander van, Ferreira, Valerie

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Seroprevalence of Pre-Existing Nabs Against AAV1, 2, 5, 6 and 8 in South African Hemophilia B Patient Population by Majowicz, Anna, Ncete, Nolukholo, van Waes, Floris, Timmer, Nikki, van Deventer, Sander J, Mahlangu, Johnny N, Ferreira, Valerie

“…Introduction Several studies have shown that the induction of antibodies by natural exposure to various AAV serotypes can compromise the subsequent use of AAV…”
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Successful Repeated Hepatic Gene Delivery in Mice and Non-human Primates Achieved by Sequential Administration of AAV5ch and AAV1 by Majowicz, Anna, Salas, David, Zabaleta, Nerea, Rodríguez-Garcia, Estefania, González-Aseguinolaza, Gloria, Petry, Harald, Ferreira, Valerie

“…In the gene therapy field, re-administration of adeno-associated virus (AAV) is an important topic because a decrease in therapeutic protein expression might…”
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THU-363-Lipid nanoparticle pre-treatment improves adeno-associated virus diffusion in the primate liver and enables an increase of therapeutic transgene expression by Kwikkers, Karin L, Schwarz, Lukas, Laat, Johannes de, Majowicz, Anna, Miranda, Paula S., Gielen, Alexander W., Haan, Martin de, Petry, Harald, Deventer, Sander van, Ferreira, Valerie

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700. Successful Repeated Hepatic Gene Delivery in Mice and Non-Human Primates Achieved by Sequential Administration of AAV5 and AAV1 Vector Serotypes by Majowicz, Anna, Salas, David, Zabaleta, Nerea, Rodríguez-Garcia, Estefania, Aseguinolaza, Gloria Gonzalez, Petry, Harald, Ferreira, Valerie

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310. Analysis of AAV5 Biodistribution and Viral Shedding in the Presence or Absence of Neutralizing Antibodies by Salas, David, Majowicz, Anna, Zabaleta, Nerea, Rodríguez-Garcia, Estefania, Petry, Harald, Ferreira, Valerie, Aseguinolaza, Gloria Gonzalez

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Mir-142-3p target sequences reduce transgene-directed immunogenicity following intramuscular adeno-associated virus 1 vector-mediated gene delivery by Majowicz, Anna, Maczuga, Piotr, Kwikkers, Karin L., van der Marel, Sander, van Logtenstein, Richard, Petry, Harald, van Deventer, Sander J., Konstantinova, Pavlina, Ferreira, Valerie

“…Background Muscle represents an important tissue target for adeno‐associated virus (AAV) vector‐mediated gene transfer in muscular, metabolic or blood‐related…”
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300. Changing the Route of Administration to Improve Liver Transduction by Recombinant AAV-Based Vectors by Zabaleta, Nerea, Salas, David, Majowicz, Anna, Hemandez-Alcoceba, Rubén, Sier-Ferreira, Valerie, Prieto, Jesús, Bilbao, Ignacio, González-Aseguinolaza, Gloria

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Mo2010 Aav5 Mediated Delivery of Regulatory T-Cell Epitope 167 Ameliorates Acute Experimental Colitis and Prevents a Type 1 Hypersensitivity Reaction in a TNBS Model of Crohn's Disease by van der Marel, Sander, Majowicz, Anna, Kwikkers, Karin L, van Logtenstein, Richard, te Velde, Anje A, De Groot, Anne S, Meijer, Sybren L, van Deventer, Sander, Petry, Harald, Hommes, Daniel W, Ferreira, Valerie

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Mir-142-3p target sequences reduce transgene directed immunogenicity following intramuscular AAV vector-mediated gene delivery by Anna, Majowicz, Piotr, Maczuga, Karin, Kwikkers, Sander, Van Der Marel, Richard, Van Logtenstein, Harald, Petry, Sander, Van Deventer, Pavlina, Konstantinova, Valerie, Ferreira

“…Abstract only…”
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Murine CD4 super(+)CD25 super(-) cells activated in vitro with PMA/ionomycin and anti-CD3 acquire regulatory function and ameliorate experimental colitis in vivo by Majowicz, Anna, van der Marel, Sander, te Velde, Anje A, Meijer, Sybren L, Petry, Harald, van Deventer, Sander J, Ferreira, Valerie

“…Background: Induced regulatory T (iTreg) lymphocytes show promise for application in the treatment of allergic, autoimmune and inflammatory disorders. iTreg…”
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