Search Results - "Major, Tanya J."

Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts by Major, Tanya J, Topless, Ruth K, Dalbeth, Nicola, Merriman, Tony R

“…AbstractObjectiveTo systematically test dietary components for association with serum urate levels and to evaluate the relative contributions of estimates of…”
Get full text

Pleiotropic effect of the ABCG2 gene in gout: involvement in serum urate levels and progression from hyperuricemia to gout by Wrigley, Rebekah, Phipps-Green, Amanda J, Topless, Ruth K, Major, Tanya J, Cadzow, Murray, Riches, Philip, Tausche, Anne-Kathrin, Janssen, Matthijs, Joosten, Leo A B, Jansen, Tim L, So, Alexander, Harré Hindmarsh, Jennie, Stamp, Lisa K, Dalbeth, Nicola, Merriman, Tony R

“…The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9,…”
Get full text

The comparative effect of exposure to various risk factors on the risk of hyperuricaemia: diet has a weak causal effect by Topless, Ruth K G, Major, Tanya J, Florez, Jose C, Hirschhorn, Joel N, Cadzow, Murray, Dalbeth, Nicola, Stamp, Lisa K, Wilcox, Philip L, Reynolds, Richard J, Cole, Joanne B, Merriman, Tony R

“…Prevention of hyperuricaemia (HU) is critical to the prevention of gout. Understanding causal relationships and relative contributions of various risk factors…”
Get full text

The relationship between ferritin and urate levels and risk of gout by Fatima, Tahzeeb, McKinney, Cushla, Major, Tanya J, Stamp, Lisa K, Dalbeth, Nicola, Iverson, Cory, Merriman, Tony R, Miner, Jeffrey N

“…Ferritin positively associates with serum urate and an interventional study suggests that iron has a role in triggering gout flares. The objective of this…”
Get full text

Mediation analysis to understand genetic relationships between habitual coffee intake and gout by Hutton, Joseph, Fatima, Tahzeeb, Major, Tanya J, Topless, Ruth, Stamp, Lisa K, Merriman, Tony R, Dalbeth, Nicola

“…Increased coffee intake is associated with reduced serum urate concentrations and lower risk of gout. Specific alleles of the GCKR, ABCG2, MLXIPL, and CYP1A2…”
Get full text

Association of rs9939609 in FTO with BMI among Polynesian peoples living in Aotearoa New Zealand and other Pacific nations by Krishnan, Mohanraj, Phipps-Green, Amanda, Russell, Emily M, Major, Tanya J, Cadzow, Murray, Stamp, Lisa K, Dalbeth, Nicola, Hindmarsh, Jennie Harré, Qasim, Muhammad, Watson, Huti, Liu, Shuwei, Carlson, Jenna C, Minster, Ryan L, Hawley, Nicola L, Naseri, Take, Reupena, Muagututi'a Sefuiva, Deka, Ranjan, McGarvey, Stephen T, Merriman, Tony R, Murphy, Rinki, Weeks, Daniel E

“…The fat mass and obesity associated (FTO) locus consistently associates with higher body mass index (BMI) across diverse ancestral groups. However, previous…”
Get full text

Mid-pass whole genome sequencing enables biomedical genetic studies of diverse populations by Emde, Anne-Katrin, Phipps-Green, Amanda, Cadzow, Murray, Gallagher, C Scott, Major, Tanya J, Merriman, Marilyn E, Topless, Ruth K, Takei, Riku, Dalbeth, Nicola, Murphy, Rinki, Stamp, Lisa K, de Zoysa, Janak, Wilcox, Philip L, Fox, Keolu, Wasik, Kaja A, Merriman, Tony R, Castel, Stephane E

“…Historically, geneticists have relied on genotyping arrays and imputation to study human genetic variation. However, an underrepresentation of diverse…”
Get full text

Trans-ancestral dissection of urate- and gout-associated major loci SLC2A9 and ABCG2 reveals primate-specific regulatory effects by Takei, Riku, Cadzow, Murray, Markie, David, Bixley, Matt, Phipps-Green, Amanda, Major, Tanya J, Li, Changgui, Choi, Hyon K, Li, Zhiqiang, Hu, Hua, Guo, Hui, He, Meian, Shi, Yongyong, Stamp, Lisa K, Dalbeth, Nicola, Merriman, Tony R, Wei, Wen-Hua

“…Gout is a complex inflammatory arthritis affecting ~20% of people with an elevated serum urate level (hyperuricemia). Gout and hyperuricemia are essentially…”
Get full text

A Polynesian-specific missense CETP variant alters the lipid profile by Moors, Jaye, Krishnan, Mohanraj, Sumpter, Nick, Takei, Riku, Bixley, Matt, Cadzow, Murray, Major, Tanya J., Phipps-Green, Amanda, Topless, Ruth, Merriman, Marilyn, Rutledge, Malcolm, Morgan, Ben, Carlson, Jenna C., Zhang, Jerry Z., Russell, Emily M., Sun, Guangyun, Cheng, Hong, Weeks, Daniel E., Naseri, Take, Reupena, Muagututi’a Sefuiva, Viali, Satupa’itea, Tuitele, John, Hawley, Nicola L., Deka, Ranjan, McGarvey, Stephen T., de Zoysa, Janak, Murphy, Rinki, Dalbeth, Nicola, Stamp, Lisa, Taumoepeau, Mele, King, Frances, Wilcox, Phillip, Rapana, Nuku, McCormick, Sally, Minster, Ryan L., Merriman, Tony R., Leask, Megan

“…Identifying population-specific genetic variants associated with disease and disease-predisposing traits is important to provide insights into the genetic…”
Get full text

CREBRF missense variant rs373863828 has both direct and indirect effects on type 2 diabetes and fasting glucose in Polynesian peoples living in Samoa and Aotearoa New Zealand by Russell, Emily M, Carlson, Jenna C, Krishnan, Mohanraj, Hawley, Nicola L, Sun, Guangyun, Cheng, Hong, Naseri, Take, Reupena, Muagututi‘a Sefuiva, Viali, Satupa‘itea, Tuitele, John, Major, Tanya J, Miljkovic, Iva, Merriman, Tony R, Deka, Ranjan, Weeks, Daniel E, McGarvey, Stephen T, Minster, Ryan L

“…IntroductionThe minor allele of a missense variant, rs373863828, in CREBRF is associated with higher body mass index (BMI), lower fasting glucose, and lower…”
Get full text

An update on the genetics of hyperuricaemia and gout by Major, Tanya J., Dalbeth, Nicola, Stahl, Eli A., Merriman, Tony R.

“…A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to the formation of monosodium urate crystals. The clinical features…”
Get full text

Genomic dissection of 43 serum urate-associated loci provides multiple insights into molecular mechanisms of urate control by Boocock, James, Leask, Megan, Okada, Yukinori, Matsuo, Hirotaka, Kawamura, Yusuke, Shi, Yongyong, Li, Changgui, Mount, David B, Mandal, Asim K, Wang, Weiqing, Cadzow, Murray, Gosling, Anna L, Major, Tanya J, Horsfield, Julia A, Choi, Hyon K, Fadason, Tayaza, O’Sullivan, Justin, Stahl, Eli A, Merriman, Tony R

“…Abstract High serum urate is a prerequisite for gout and associated with metabolic disease. Genome-wide association studies (GWAS) have reported dozens of loci…”
Get full text

The epigenome: key to understanding and predicting gout flares by Wolyncewicz, Ben, Major, Tanya J., Delahunt, Brett, Thunders, Michelle

“…Gout is a form of arthritis, resulting from an inflammatory reaction to the deposition of monosodium urate (MSU) crystals in the synovial fluid of the joint…”
Get full text

A Polynesian-specific copy number variant encompassing the MICA gene associates with gout by Wang, Ke, Cadzow, Murray, Bixley, Matt, Leask, Megan P, Merriman, Marilyn E, Yang, Qiangzhen, Li, Zhiqiang, Takei, Riku, Phipps-Green, Amanda, Major, Tanya J, Topless, Ruth, Dalbeth, Nicola, King, Frances, Murphy, Rinki, Stamp, Lisa K, de Zoysa, Janak, Wang, Zhuo, Shi, Yongyong, Merriman, Tony R

“…Abstract Gout is of particularly high prevalence in the Māori and Pacific (Polynesian) populations of Aotearoa New Zealand (NZ). Here, we investigated the…”
Get full text

Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients by Nakayama, Akiyoshi, Nakatochi, Masahiro, Kawamura, Yusuke, Yamamoto, Ken, Nakaoka, Hirofumi, Shimizu, Seiko, Higashino, Toshihide, Koyama, Teruhide, Hishida, Asahi, Kuriki, Kiyonori, Watanabe, Miki, Shimizu, Toru, Ooyama, Keiko, Ooyama, Hiroshi, Nagase, Mitsuo, Hidaka, Yuji, Matsui, Daisuke, Tamura, Takashi, Nishiyama, Takeshi, Shimanoe, Chisato, Katsuura-Kamano, Sakurako, Takashima, Naoyuki, Shirai, Yuya, Kawaguchi, Makoto, Takao, Mikiya, Sugiyama, Ryo, Takada, Yuzo, Nakamura, Takahiro, Nakashima, Hiroshi, Tsunoda, Masashi, Danjoh, Inaho, Hozawa, Atsushi, Hosomichi, Kazuyoshi, Toyoda, Yu, Kubota, Yu, Takada, Tappei, Suzuki, Hiroshi, Stiburkova, Blanka, Major, Tanya J, Merriman, Tony R, Kuriyama, Nagato, Mikami, Haruo, Takezaki, Toshiro, Matsuo, Keitaro, Suzuki, Sadao, Hosoya, Tatsuo, Kamatani, Yoichiro, Kubo, Michiaki, Ichida, Kimiyoshi, Wakai, Kenji, Inoue, Ituro, Okada, Yukinori, Shinomiya, Nariyoshi, Matsuo, Hirotaka

“…Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure…”
Get more information

Aotearoa New Zealand Māori and Pacific Population-amplified Gout Risk Variants: CLNK Is a Separate Risk Gene at the SLC2A9 Locus by Ji, Aichang, Shaukat, Amara, Takei, Riku, Bixley, Matthew, Cadzow, Murray, Topless, Ruth K., Major, Tanya J., Phipps-Green, Amanda, Merriman, Marilyn E., Hindmarsh, Jennie Harré, Stamp, Lisa K., Dalbeth, Nicola, Li, Changgui, Merriman, Tony R.

“…Objective The Māori and Pacific (Polynesian) population of Aotearoa New Zealand has a high prevalence of gout. Our aim was to identify potentially functional…”
Get full text

Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand by Krishnan, Mohanraj, Major, Tanya J., Topless, Ruth K., Dewes, Ofa, Yu, Lennex, Thompson, John M. D., McCowan, Lesley, de Zoysa, Janak, Stamp, Lisa K., Dalbeth, Nicola, Harré Hindmarsh, Jennie, Rapana, Nuku, Deka, Ranjan, Eng, Winston W. H., Weeks, Daniel E., Minster, Ryan L., McGarvey, Stephen T., Viali, Satupa’itea, Naseri, Take, Sefuiva Reupena, Muagututi’a, Wilcox, Phillip, Grattan, David, Shepherd, Peter R., Shelling, Andrew N., Murphy, Rinki, Merriman, Tony R.

“…Aims/hypothesis The A (minor) allele of CREBRF rs373863828 has been associated with increased BMI and reduced risk of type 2 diabetes in the Samoan populations…”
Get full text

Multivariate analysis of a missense variant in CREBRF reveals associations with measures of adiposity in people of Polynesian ancestries by Zhang, Jerry Z., Heinsberg, Lacey W., Krishnan, Mohanraj, Hawley, Nicola L., Major, Tanya J., Carlson, Jenna C., Harré Hindmarsh, Jennie, Watson, Huti, Qasim, Muhammad, Stamp, Lisa K., Dalbeth, Nicola, Murphy, Rinki, Sun, Guangyun, Cheng, Hong, Naseri, Take, Reupena, Muagututi'a S., Kershaw, Erin E., Deka, Ranjan, McGarvey, Stephen T., Minster, Ryan L., Merriman, Tony R., Weeks, Daniel E.

“…The minor allele of rs373863828, a missense variant in CREB3 Regulatory Factor, is associated with several cardiometabolic phenotypes in Polynesian peoples. To…”
Get full text

Dietary Sodium Modifies Serum Uric Acid Concentrations in Humans by Todd, Alwyn S, Walker, Robert J, MacGinley, Robert J, Kelly, Jaimon, Merriman, Tony R, Major, Tanya J, Johnson, Richard J

“…Subjects with hypertension are frequently obese or insulin resistant, both conditions in which hyperuricemia is common. Obese and insulin-resistant subjects…”
Get full text

Re: “Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood” by Major, Tanya J, Krishnan, Mohanraj, Topless, Ruth K, Dewes, Ofa, Thompson, John, Zoysa, Janak de, Stamp, Lisa K, Dalbeth, Nicola, Deka, Ranjan, Weeks, Daniel E, Minster, Ryan L, Wilcox, Phillip, Grattan, David, Shepherd, Peter R, Shelling, Andrew N, Murphy, Rinki, Merriman, Tony R

Get full text