Search Results - "Major, Michael B"

NRF2 Activation in Cancer: From DNA to Protein by Cloer, Erica W, Goldfarb, Dennis, Schrank, Travis P, Weissman, Bernard E, Major, Michael B

“…The Cancer Genome Atlas catalogued alterations in the Kelch-like ECH-associated protein 1 and nuclear factor erythroid 2-related factor 2 (NRF2) signaling…”
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Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus by Fu, Junsheng, Xiong, Zhaohui, Huang, Caizhi, Li, Jing, Yang, Wenjun, Han, Yuning, Paiboonrungruan, Chorlada, Major, Michael B., Chen, Ke-Neng, Kang, Xiaozheng, Chen, Xiaoxin

“…Mutations in the genes encoding nuclear factor (erythroid-derived 2)-like 2 (NRF2), Kelch-like ECH-associated protein 1 (KEAP1), and cullin 3 (CUL3) are…”
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ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas by Nguyen, Vinh, Schrank, Travis P, Major, Michael B, Weissman, Bernard E

“…Prior to the next generation sequencing and characterization of the tumor genome landscape, mutations in the SWI/SNF chromatin remodeling complex and the…”
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The mucolipidosis IV Ca2+ channel TRPML1 (MCOLN1) is regulated by the TOR kinase by Onyenwoke, Rob U, Sexton, Jonathan Z, Yan, Feng, Díaz, María Cristina Huertas, Forsberg, Lawrence J, Major, Michael B, Brenman, Jay E

“…Autophagy is a complex pathway regulated by numerous signalling events that recycles macromolecules and may be perturbed in lysosomal storage disorders (LSDs)…”
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BRG1/SMARCA4 inactivation promotes non-small cell lung cancer aggressiveness by altering chromatin organization by Orvis, Tess, Hepperla, Austin, Walter, Vonn, Song, Shujie, Simon, Jeremy, Parker, Joel, Wilkerson, Matthew D, Desai, Nisarg, Major, Michael B, Hayes, D Neil, Davis, Ian J, Weissman, Bernard

“…SWI/SNF chromatin remodeling complexes regulate critical cellular processes, including cell-cycle control, programmed cell death, differentiation, genomic…”
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Glycosylation of KEAP1 links nutrient sensing to redox stress signaling by Chen, Po‐Han, Smith, Timothy J, Wu, Jianli, Siesser, Priscila F, Bisnett, Brittany J, Khan, Farhan, Hogue, Maxwell, Soderblom, Erik, Tang, Flora, Marks, Jeffrey R, Major, Michael B, Swarts, Benjamin M, Boyce, Michael, Chi, Jen‐Tsan

“…O‐GlcNAcylation is an essential, nutrient‐sensitive post‐translational modification, but its biochemical and phenotypic effects remain incompletely understood…”
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TCAF1 promotes TRPV2-mediated Ca2+ release in response to cytosolic DNA to protect stressed replication forks by Kong, Lingzhen, Cheng, Chen, Cheruiyot, Abigael, Yuan, Jiayi, Yang, Yichan, Hwang, Sydney, Foust, Daniel, Tsao, Ning, Wilkerson, Emily, Mosammaparast, Nima, Major, Michael B., Piston, David W., Li, Shan, You, Zhongsheng

“…The protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for…”
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Engineered Cas9 variants bypass Keap1-mediated degradation in human cells and enhance epigenome editing efficiency by Chen, Jianfeng, Su, Siyuan, Pickar-Oliver, Adrian, Chiarella, Anna M, Hahn, Quentin, Goldfarb, Dennis, Cloer, Erica W, Small, George W, Sivashankar, Smaran, Ramsden, Dale A, Major, Michael B, Hathaway, Nathaniel A, Gersbach, Charles A, Liu, Pengda

“…As a potent and convenient genome-editing tool, Cas9 has been widely used in biomedical research and evaluated in treating human diseases. Numerous engineered…”
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Author Correction: A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis by Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus

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The Cancer/Testes (CT) Antigen HORMAD1 promotes Homologous Recombinational DNA Repair and Radioresistance in Lung adenocarcinoma cells by Gao, Yanzhe, Kardos, Jordan, Yang, Yang, Tamir, Tigist Y., Mutter-Rottmayer, Elizabeth, Weissman, Bernard, Major, Michael B., Kim, William Y., Vaziri, Cyrus

“…The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks…”
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Distinct Wnt signaling pathways have opposing roles in appendage regeneration by Stoick-Cooper, Cristi L, Weidinger, Gilbert, Riehle, Kimberly J, Hubbert, Charlotte, Major, Michael B, Fausto, Nelson, Moon, Randall T

“…In contrast to mammals, lower vertebrates have a remarkable capacity to regenerate complex structures damaged by injury or disease. This process, termed…”
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Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate by Mulvaney, Kathleen M., Matson, Jacob P., Siesser, Priscila F., Tamir, Tigist Y., Goldfarb, Dennis, Jacobs, Timothy M., Cloer, Erica W., Harrison, Joseph S., Vaziri, Cyrus, Cook, Jeanette G., Major, Michael B.

“…KEAP1 is a substrate adaptor protein for a CUL3-based E3 ubiquitin ligase. Ubiquitylation and degradation of the antioxidant transcription factor NRF2 is…”
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USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds by Madan, Babita, Walker, Matthew P., Young, Robert, Quick, Laura, Orgel, Kelly A., Ryan, Meagan, Gupta, Priti, Henrich, Ian C., Ferrer, Marc, Marine, Shane, Roberts, Brian S., Arthur, William T., Berndt, Jason D., Oliveira, Andre M., Moon, Randall T., Virshup, David M., Chou, Margaret M., Major, Michael B.

“…The Wnt signaling pathways play pivotal roles in carcinogenesis. Modulation of the cell-surface abundance of Wnt receptors is emerging as an important…”
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A basally active cGAS-STING pathway limits SARS-CoV-2 replication in a subset of ACE2 positive airway cell models by Puray-Chavez, Maritza, Eschbach, Jenna E., Xia, Ming, LaPak, Kyle M., Zhou, Qianzi, Jasuja, Ria, Pan, Jiehong, Xu, Jian, Zhou, Zixiang, Mohammed, Shawn, Wang, Qibo, Lawson, Dana Q., Djokic, Sanja, Hou, Gaopeng, Ding, Siyuan, Brody, Steven L., Major, Michael B., Goldfarb, Dennis, Kutluay, Sebla B.

“…Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. Here we report that SARS-CoV-2 replication is…”
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A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis by Gao, Yanzhe, Mutter-Rottmayer, Elizabeth, Greenwalt, Alicia M., Goldfarb, Dennis, Yan, Feng, Yang, Yang, Martinez-Chacin, Raquel C., Pearce, Kenneth H., Tateishi, Satoshi, Major, Michael B., Vaziri, Cyrus

“…Trans-lesion synthesis (TLS) is an important DNA-damage tolerance mechanism that permits ongoing DNA synthesis in cells harbouring damaged genomes. The E3…”
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WIKI4, a novel inhibitor of tankyrase and Wnt/ß-catenin signaling by James, Richard G, Davidson, Kathryn C, Bosch, Katherine A, Biechele, Travis L, Robin, Nicholas C, Taylor, Russell J, Major, Michael B, Camp, Nathan D, Fowler, Kerry, Martins, Timothy J, Moon, Randall T

“…The Wnt/ß-catenin signaling pathway controls important cellular events during development and often contributes to disease when dysregulated. Using high…”
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Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1 by Harrison, Joseph S, Cornett, Evan M, Goldfarb, Dennis, DaRosa, Paul A, Li, Zimeng M, Yan, Feng, Dickson, Bradley M, Guo, Angela H, Cantu, Daniel V, Kaustov, Lilia, Brown, Peter J, Arrowsmith, Cheryl H, Erie, Dorothy A, Major, Michael B, Klevit, Rachel E, Krajewski, Krzysztof, Kuhlman, Brian, Strahl, Brian D, Rothbart, Scott B

“…The epigenetic inheritance of DNA methylation requires UHRF1, a histone- and DNA-binding RING E3 ubiquitin ligase that recruits DNMT1 to sites of newly…”
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Wilms Tumor Gene on X Chromosome (WTX) Inhibits Degradation of NRF2 Protein through Competitive Binding to KEAP1 Protein by Camp, Nathan D., James, Richard G., Dawson, David W., Yan, Feng, Davison, James M., Houck, Scott A., Tang, Xiaobo, Zheng, Ning, Major, Michael B., Moon, Randall T.

“…WTX is a tumor suppressor protein that is lost or mutated in up to 30% of cases of Wilms tumor. Among its known functions, WTX interacts with the β-transducin…”
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Ginger Compound [6]-Shogaol and Its Cysteine-Conjugated Metabolite (M2) Activate Nrf2 in Colon Epithelial Cells in Vitro and in Vivo by Chen, Huadong, Fu, Junsheng, Chen, Hao, Hu, Yuhui, Soroka, Dominique N, Prigge, Justin R, Schmidt, Edward E, Yan, Feng, Major, Michael B, Chen, Xiaoxin, Sang, Shengmin

“…In this study, we identified Nrf2 as a molecular target of [6]-shogaol (6S), a bioactive compound isolated from ginger, in colon epithelial cells in vitro and…”
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Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors by Witherspoon, John G., Hall, Jonathan R., Jima, Dereje, Atkins, Hannah M., Wamsley, Nathan T., Major, Michael B., Weissman, Bernard E., Smart, Robert C.

“…Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway…”
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