Search Results - "Majireck, Max M."

Total Syntheses of the Monoterpene Indole Alkaloids (±)-Alstilobanine A and E and (±)-Angustilodine by Feng, Yiqing, Majireck, Max M, Weinreb, Steven M

“…A synthetic strategy has been developed culminating in stereoselective total syntheses of the small class of unusual monoterpenoid indole alkaloids exemplified…”
Get full text

Synthesis of Bench-Stable N-Quaternized Ketene N,O‑Acetals and Preliminary Evaluation as Reagents in Organic Synthesis by McConnell, Danielle L, Blades, Alisha M, Rodrigues, Danielle Gomes, Keyes, Phoebe V, Sonberg, Justin C, Anthony, Caitlin E, Rachad, Sofia, Simone, Olivia M, Sullivan, Caroline F, Shapiro, Jonathan D, Williams, Christopher C, Schafer, Benjamin C, Glanzer, Amy M, Hutchinson, Holly L, Thayaparan, Ashley B, Krevlin, Zoe A, Bote, Isabella C, Haffary, Yasin A, Bhandari, Sambat, Goodman, Jack A, Majireck, Max M

“…N-Quaternized ketene N,O-acetals are typically an unstable, transient class of compounds most commonly observed as reactive intermediates. In this report, we…”
Get full text

Total Synthesis of the Unusual Monoterpenoid Indole Alkaloid (±)-Alstilobanine A by Feng, Yiqing, Majireck, Max M., Weinreb, Steven M.

“…Tetracyclic monoterpene alkaloid alstilobanine A was obtained in racemic form. The pivotal steps of the total synthesis are a novel conjugate addition of an…”
Get full text

Synthesis, Characterization, and Computational Modeling of N-(1-Ethoxyvinyl)pyridinium Triflates, an Unusual Class of Pyridinium Salts by Shapiro, Jonathan D, Sonberg, Justin C, Schafer, Benjamin C, Williams, Christopher C, Ferris, Hannah R, Reinheimer, Eric W, Van Wynsberghe, Adam W, Kriley, Charles E, Majireck, Max M

“…-Substituted pyridinium salts constitute one of the most valuable reagent classes in organic synthesis, due to their versatility and ease of use. Herein we…”
Get full text

Niche-Based Screening in Multiple Myeloma Identifies a Kinesin-5 Inhibitor with Improved Selectivity over Hematopoietic Progenitors by Chattopadhyay, Shrikanta, Stewart, Alison L., Mukherjee, Siddhartha, Huang, Cherrie, Hartwell, Kimberly A., Miller, Peter G., Subramanian, Radhika, Carmody, Leigh C., Yusuf, Rushdia Z., Sykes, David B., Paulk, Joshiawa, Vetere, Amedeo, Vallet, Sonia, Santo, Loredana, Cirstea, Diana D., Hideshima, Teru, Dančík, Vlado, Majireck, Max M., Hussain, Mahmud M., Singh, Shambhavi, Quiroz, Ryan, Iaconelli, Jonathan, Karmacharya, Rakesh, Tolliday, Nicola J., Clemons, Paul A., Moore, Malcolm A.S., Stern, Andrew M., Shamji, Alykhan F., Ebert, Benjamin L., Golub, Todd R., Raje, Noopur S., Scadden, David T., Schreiber, Stuart L.

“…Novel therapeutic approaches are urgently required for multiple myeloma (MM). We used a phenotypic screening approach using co-cultures of MM cells with bone…”
Get full text

A Study of the Scope and Regioselectivity of the Ruthenium-Catalyzed [3 + 2]-Cycloaddition of Azides with Internal Alkynes by Majireck, Max M, Weinreb, Steven M

“…[3 + 2]-Cycloadditions of alkyl azides with various unsymmetrical internal alkynes in the presence of Cp*RuCl(PPh3)2 as catalyst in refluxing benzene have been…”
Get full text

Bench-Stable 2-Halopyridinium Ketene Hemiaminals as Reagents for the Synthesis of 2-Aminopyridine Derivatives by Bote, Isabelle C, Krevlin, Zoe A, Crespo, Maria Christina F, Udomphan, Sudchananya, Levin, Carolyn T, Lam, Christie C, Glanzer, Amy M, Hutchinson, Holly L, Blades, Alisha M, McConnell, Danielle L, Lin, Crystal, Frank, John P, Strutton, William R, Merklin, Jordan C, Sinardo, Beau A, Gueye, Khady J, Leiman, Karly V, Thayaparan, Ashley, Adade, Joel K A, Martinez, Nestor L, Kramer, Wesley W, Majireck, Max M

“…2-Chloro-1-(1-ethoxyvinyl)pyridinium triflate and several other bench-stable -(1-alkoxyvinyl) 2-halopyridinium triflates have been developed as reagents for…”
Get full text

Synthesis of phthalan and phenethylamine derivatives via addition of alcohols to rhodium(II)-azavinyl carbenoids by Bennett, John M., Shapiro, Jonathan D., Choinski, Krystina N., Mei, Yingbin, Aulita, Sky M., Reinheimer, Eric W., Majireck, Max M.

“…[Display omitted] •Cyclization of alcohols to Rh(II)-azavinyl carbenoids provides furans/phthalans.•Products contain a synthetically versatile…”
Get full text

Synthesis and crystal structure of a bench-stable pyridinium ketene hemiaminal: 1-(1-ethoxyethenyl)-2-[methyl(phenyl)amino]pyridin-1-ium trifluoromethanesulfonate by Krevlin, Zoe A., Bote, Isabella C., Crespo, Maria Christina F., Lam, Christie C., McMillen, Colin D., Majireck, Max M.

“…The novel bench-stable N -quaternized ketene N , O -acetal, C 16 H 19 N 2 O + ·CF 3 O 3 S − , was synthesized and its structure determined. The title compound…”
Get full text

Alternative Synthesis and Structural Analysis of the Antioxidant and Antitumor Agent 2-(3,5-Dimethoxyphenyl)-2,3-Dihydroquinolin-4(1H)-One by Parry, Christopher S., Grossmann, Matthew D., Thomas, Amy, Majireck, Max M., Reinheimer, Eric W., Kriley, Charles E.

“…Herein we present the synthesis, structure and NMR and mass spectroscopic analyses of the antioxidant 2-(3,5-dimethoxyphenyl)-2,3-dihydroquinolin-4(1 H )-one (…”
Get full text

Synthesis and crystal structure of a bench-stable pyridinium ketene hemiaminal: 1-(1-eth-oxy-ethen-yl)-2-[meth-yl(phen-yl)amino]-pyridin-1-ium tri-fluoro-methane-sulfonate by Krevlin, Zoe A, Bote, Isabella C, Crespo, Maria Christina F, Lam, Christie C, McMillen, Colin D, Majireck, Max M

“…The N -quaternized ketene N , O -acetal, 1-(1-eth­oxy­vin­yl)-2-(meth­yl(phen­yl)amino)­pyridin-1-ium tri­fluoro­methane­sulfonate was synthesized and its…”
Get full text

Efficient methodology for alkylation of vinylnitroso compounds with carbon nucleophiles by Li, Puhui, Majireck, Max M., Witek, Jason A., Weinreb, Steven M.

“…A diverse array of nitrosoalkenes derived from both acyclic and cyclic ketones, as well as aldehydes, via the Denmark protocol using α-chloro-O-TBS-oximes can…”
Get full text

An expedient reductive method for conversion of ketoximes to the corresponding carbonyl compounds by Majireck, Max M., Witek, Jason A., Weinreb, Steven M.

“…A wide array of readily prepared pivalates of ketoximes can be converted to their corresponding ketones in good yields by treatment with iron powder in THF…”
Get full text

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines by Bennett, John M, Shapiro, Jonathan D, Choinski, Krystina N, Mei, Yingbin, Aulita, Sky M, Dominguez, Giovanny M, Majireck, Max M

“…Decomposition of N-tosyl-1,2,3-triazoles with rhodium(II) acetate dimer in the presence of alcohols forms synthetically versatile…”
Get full text

A mild, efficient method for the oxidation of α-diazo-β-hydroxyesters to α-diazo-β-ketoesters by Li, Puhui, Majireck, Max M., Korboukh, Ilia, Weinreb, Steven M.

“…A variety of α-diazo-β-ketoesters can be prepared in high yields via addition of ethyl lithiodiazoacetate to aliphatic, aromatic, and α,β-unsaturated…”
Get full text

Regioselective α-Monochlorination of N-Protected-3-piperidones by M. Weinreb, Steven, S. Chauhan, Pradeep, M. Majireck, Max

Get full text

Alternative Synthesis and Structural Analysis of the Antioxidant and Antitumor Agent 2--One by Parry, Christopher S, Grossmann, Matthew D, Thomas, Amy, Majireck, Max M, Reinheimer, Eric W, Kriley, Charles E

“…Herein we present the synthesis, structure and NMR and mass spectroscopic analyses of the antioxidant 2-(3,5-dimethoxyphenyl)-2,3-dihydroquinolin-4(1H)-one…”
Get full text

Total Synthesis of the Unusual Monoterpenoid Indole Alkaloid (±)-AlstilobanineA by Feng, Yiqing, Majireck, Max M, Weinreb, Steven M

“…Tetracyclic monoterpene alkaloid alstilobanineA was obtained in racemic form. The pivotal steps of the total synthesis are a novel conjugate addition of an…”
Get full text

Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines by Bennett, John M., Shapiro, Jonathan D., Choinski, Krystina N., Mei, Yingbin, Aulita, Sky M., Dominguez, Giovanny M., Majireck, Max M.

Get full text

Total Synthesis of the Unusual Monoterpenoid Indole Alkaloid (±)-Alstilobanine A by Feng, Yiqing, Majireck, Max M., Weinreb, Steven M.

“…Das tetracyclische Monoterpen‐Alkaloid Alstilobanin A wurde in racemischer Form erhalten. Wichtige Stufen seiner Totalsynthese sind eine neuartige konjugierte…”
Get full text