Search Results - "Maji, Samir K."

Role of non-specific interactions in the phase-separation and maturation of macromolecules by Krishnan, Rakesh, Ranganathan, Srivastav, Maji, Samir K, Padinhateeri, Ranjith

“…Phase separation of biomolecules could be mediated by both specific and non-specific interactions. How the interplay between non-specific and specific…”
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In vivo demonstration that α-synuclein oligomers are toxic by Winner, Beate, Jappelli, Roberto, Maji, Samir K, Desplats, Paula A, Boyer, Leah, Aigner, Stefan, Hetzer, Claudia, Loher, Thomas, Vilar, Marçal, Campioni, Silvia, Tzitzilonis, Christos, Soragni, Alice, Jessberger, Sebastian, Mira, Helena, Consiglio, Antonella, Pham, Emiley, Masliah, Eliezer, Gage, Fred H, Riek, Roland

“…The aggregation of proteins into oligomers and amyloid fibrils is characteristic of several neurodegenerative diseases, including Parkinson disease (PD). In…”
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Intermolecular interactions underlie protein/peptide phase separation irrespective of sequence and structure at crowded milieu by Poudyal, Manisha, Patel, Komal, Gadhe, Laxmikant, Sawner, Ajay Singh, Kadu, Pradeep, Datta, Debalina, Mukherjee, Semanti, Ray, Soumik, Navalkar, Ambuja, Maiti, Siddhartha, Chatterjee, Debdeep, Devi, Jyoti, Bera, Riya, Gahlot, Nitisha, Joseph, Jennifer, Padinhateeri, Ranjith, Maji, Samir K.

“…Liquid-liquid phase separation (LLPS) has emerged as a crucial biological phenomenon underlying the sequestration of macromolecules (such as proteins and…”
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Structural and Functional Insights into α-Synuclein Fibril Polymorphism by Mehra, Surabhi, Gadhe, Laxmikant, Bera, Riya, Sawner, Ajay Singh, Maji, Samir K

“…Abnormal accumulation of aggregated α-synuclein (α-Syn) is seen in a variety of neurodegenerative diseases, including Parkinson's disease (PD), multiple system…”
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Phase separation and other forms of α-Synuclein self-assemblies by Poudyal, Manisha, Sakunthala, Arunima, Mukherjee, Semanti, Gadhe, Laxmikant, Maji, Samir K

“…α-Synuclein (α-Syn) is a natively unstructured protein, which self-assembles into higher-order aggregates possessing serious pathophysiological implications…”
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Comparison of α‑Synuclein Fibril Inhibition by Four Different Amyloid Inhibitors by Jha, Narendra Nath, Kumar, Rakesh, Panigrahi, Rajlaxmi, Navalkar, Ambuja, Ghosh, Dhiman, Sahay, Shruti, Mondal, Mritunjoy, Kumar, Ashutosh, Maji, Samir. K

“…Aggregation of α-synuclein (α-Syn) into toxic oligomers and fibrils leads to Parkinson’s disease (PD) pathogenesis. Molecules that can inhibit the…”
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Direct evidence of cellular transformation by prion-like p53 amyloid infection by Navalkar, Ambuja, Pandey, Satyaprakash, Singh, Namrata, Patel, Komal, Datta, Debalina, Mohanty, Bhabani, Jadhav, Sachin, Chaudhari, Pradip, Maji, Samir K

“…Tumor suppressor p53 mutations are associated with more than 50% of cancers. Aggregation and amyloid formation of p53 is also implicated in cancer…”
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Functional Amyloids As Natural Storage of Peptide Hormones in Pituitary Secretory Granules by Maji, Samir K, Perrin, Marilyn H, Sawaya, Michael R, Jessberger, Sebastian, Vadodaria, Krishna, Rissman, Robert A, Singru, Praful S, Nilsson, K. Peter R, Simon, Rozalyn, Schubert, David, Eisenberg, David, Rivier, Jean, Sawchenko, Paul, Vale, Wylie, Riek, Roland

“…Amyloids are highly organized cross-β-sheet-rich protein or peptide aggregates that are associated with pathological conditions including Alzheimer's disease…”
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p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis by Ghosh, Saikat, Salot, Shimul, Sengupta, Shinjinee, Navalkar, Ambuja, Ghosh, Dhiman, Jacob, Reeba, Das, Subhadeep, Kumar, Rakesh, Jha, Narendra Nath, Sahay, Shruti, Mehra, Surabhi, Mohite, Ganesh M, Ghosh, Santanu K, Kombrabail, Mamata, Krishnamoorthy, Guruswamy, Chaudhari, Pradip, Maji, Samir K

“…The transcriptional regulator p53 has an essential role in tumor suppression. Almost 50% of human cancers are associated with the loss of p53 functions, where…”
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fold of α-synuclein fibrils by Vilar, Marçal, Chou, Hui-Ting, Lührs, Thorsten, Maji, Samir K, Riek-Loher, Dominique, Verel, Rene, Manning, Gerard, Stahlberg, Henning, Riek, Roland

“…The aggregation of proteins into amyloid fibrils is associated with several neurodegenerative diseases. In Parkinson's disease it is believed that the…”
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Fabrication of Silver Nanowire/Polydimethylsiloxane Dry Electrodes by a Vacuum Filtration Method for Electrophysiological Signal Monitoring by Kisannagar, Ravinder Reddy, Jha, Pallavi, Navalkar, Ambuja, Maji, Samir K, Gupta, Dipti

“…Flexible and dry electrodes have attracted huge attention due to their potential application in long-term electrophysiological signal monitoring. In this work,…”
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Bacterial inclusion bodies contain amyloid-like structure by Wang, Lei, Maji, Samir K, Sawaya, Michael R, Eisenberg, David, Riek, Roland

“…Protein aggregation is a process in which identical proteins self-associate into imperfectly ordered macroscopic entities. Such aggregates are generally…”
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Amyloid as a depot for the formulation of long-acting drugs by Maji, Samir K, Schubert, David, Rivier, Catherine, Lee, Soon, Rivier, Jean E, Riek, Roland

“…Amyloids are highly organized protein aggregates that are associated with both neurodegenerative diseases such as Alzheimer disease and benign functions like…”
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α-Synuclein misfolding and aggregation: Implications in Parkinson’s disease pathogenesis by Mehra, Surabhi, Sahay, Shruti, Maji, Samir K.

“…α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical properties owing to its pathophysiological role in Parkinson’s disease…”
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Alteration of Structure and Aggregation of α-Synuclein by Familial Parkinson's Disease Associated Mutations by Sahay, Shruti, Ghosh, Dhiman, Singh, Pardeep K, Maji, Samir K

“…α-Synuclein (α-Syn) aggregation is directly associated with Parkinson's disease (PD) pathogenesis. In vitro aggregation and in vivo animal model studies of…”
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Investigating the Intrinsic Aggregation Potential of Evolutionarily Conserved Segments in p53 by Ghosh, Saikat, Ghosh, Dhiman, Ranganathan, Srivastav, Anoop, A, P, Santosh Kumar, Jha, Narendra Nath, Padinhateeri, Ranjith, Maji, Samir K

“…Protein aggregation and amyloid formation are known to play a role both in diseases and in biological functions. Transcription factor p53 plays a major role in…”
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Conjugated Polyfluorene-based Reversible Fluorescent Sensor for Cu(II) and Cyanide Ions in Aqueous Medium by Chakraborty, Chanchal, Singh, Pradeep, Maji, Samir K, Malik, Sudip

“…A blue emissive polyfluorene bearing sulfate functionality in the side chain (PFS), as a sensory polymer to selectively report the presence of Cu2+ (detection…”
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Structure–activity relationship of amyloid fibrils by Maji, Samir K., Wang, Lei, Greenwald, Jason, Riek, Roland

“…Protein aggregation is a process in which proteins self-associate into imperfectly ordered macroscopic entities. Such aggregates are generally classified as…”
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Modulation of the mitochondrial voltage dependent anion channel (VDAC) by curcumin by Tewari, Debanjan, Ahmed, Tofayel, Chirasani, Venkat R., Singh, Pradeep K., Maji, Samir K., Senapati, Sanjib, Bera, Amal Kanti

“…Voltage dependent anion channel (VDAC) of mitochondria plays a crucial role in apoptosis. Human VDAC-1, reconstituted in planar lipid bilayer showed reduced…”
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Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids by Chatterjee, Debdeep, Jacob, Reeba S, Ray, Soumik, Navalkar, Ambuja, Singh, Namrata, Sengupta, Shinjinee, Gadhe, Laxmikant, Kadu, Pradeep, Datta, Debalina, Paul, Ajoy, Arunima, Sakunthala, Mehra, Surabhi, Pindi, Chinmai, Kumar, Santosh, Singru, Praful, Senapati, Sanjib, Maji, Samir K

“…Synergistic-aggregation and cross-seeding by two different proteins/peptides in the amyloid aggregation are well evident in various neurological disorders…”
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