Search Results - "Majello, B."

Lysine-specific demethylase LSD1 regulates autophagy in neuroblastoma through SESN2-dependent pathway by Ambrosio, S, Saccà, C D, Amente, S, Paladino, S, Lania, L, Majello, B

“…Autophagy is a physiological process, important for recycling of macromolecules and maintenance of cellular homeostasis. Defective autophagy is associated with…”
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LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription by Amente, S, Bertoni, A, Morano, A, Lania, L, Avvedimento, E V, Majello, B

“…Myc is a transcription factor that significantly contributes to cancer progression by modulating the expression of important genes through binding to a DNA…”
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Transcriptional regulation by the Sp family proteins by Lania, Luigi, Majello, Barbara, de Luca, Pasquale

“…Spl is one of the very first cellular transcription factors to be identified and cloned in virtue of its binding to a Grich motif in the SV40 early promoter…”
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Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation by Turano, Mimmo, Napolitano, Giuliana, Dulac, Cyprien, Majello, Barbara, Bensaude, Olivier, Lania, Luigi

“…The HEXIM1 protein, in association with 7SK snRNA, binds and inhibits the kinase activity of P‐TEFb (CDK9/cyclin T). P‐TEFb activity is crucial for efficient…”
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Constitutive and IL‐6‐induced nuclear factors that interact with the human C‐reactive protein promoter by Majello, B., Arcone, R., Toniatti, C., Ciliberto, G.

“…Transcription of the human C‐reactive protein (CRP) gene is induced by interleukin‐6 (IL‐6) during acute inflammation. Important information for inducible CRP…”
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Recruitment of human TBP selectively activates RNA polymerase II TATA-dependent promoters by Majello, B, Napolitano, G, De Luca, P, Lania, L

“…An increasing body of evidence suggests that eukaryotic activators stimulate polymerase II transcription by facilitating the assembly of the functional basal…”
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Human c-myb Protooncogene: Nucleotide Sequence of cDNA and Organization of the Genomic Locus by Majello, Barbara, Kenyon, Lawrence C., Dalla-Favera, Riccardo

“…We have isolated cDNA clones of the human c-myb mRNA that contain ≈ 3.4 kilobases of the ≈ 3.8-kilobase mRNA sequence. Nucleotide sequence analysis shows that…”
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Control of RNA polymerase II activity by dedicated CTD kinases and phosphatases by Majello, B, Napolitano, G

“…The elongation phase of eukaryotic transcription by RNA polymerase II (RNAPII) is an important target for regulation of gene expression. An interplay of…”
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Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression by Amente, S., Zhang, J., Lavadera, M. L., Lania, L., Avvedimento, E. V., Majello, B.

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Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation by Amente, Stefano, Napolitano, Giuliana, Licciardo, Paolo, Monti, Maria, Pucci, Piero, Lania, Luigi, Majello, Barbara

“…FCP1, a phosphatase specific of the carboxyl-terminal-domain of the large subunit of the RNA polymerase II (RNAPII), stimulates transcription elongation and it…”
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Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression Domains by Majello, Barbara, De Luca, Pasquale, Lania, Luigi

“…Sp3 is a member of the Sp family of transcription factors and binds to DNA with affinity and specificity comparable to that of Sp1. We demonstrate that Sp3 is…”
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Regulation of the human C-reactive protein gene, a major marker of inflammation and cancer by Toniatti, C, Arcone, R, Majello, B, Ganter, U, Arpaia, G, Ciliberto, G

“…Human C-reactive protein (CRP) is the major acute phase reactant during inflammation. Regulation of CRP gene expression has been studied in two experimental…”
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Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1 by Majello, B, De Luca, P, Hagen, G, Suske, G, Lania, L

“…Recently, a family of transcription factors structurally related to Sp1 has been described; thus, more than one activator may bind to the GC boxes present in a…”
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p14 super(A) super(R) super(F) interacts with N-Myc and inhibits its transcriptional activity by Amente, S, Gargano, B, Diolaiti, D, Della Valle, G, Lania, L, Majello, B

“…In this study, we report that the human p14 super(A) super(R) super(F) associates in vivo with the N-Myc and inhibits N-Myc mediated transcriptional…”
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Catalytic activity of Cdk9 is required for nuclear co-localization of the Cdk9/cyclin T1 (P-TEFb) complex by Napolitano, Giuliana, Majello, Barbara, Lania, Luigi

“…Cdk9 and its binding partner cyclin T1 comprise the positive elongation factor b (P‐TEFb). P‐TEFb phosphorylates the RNA polymerase II carboxyl‐terminal‐domain…”
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Role of cyclinT/Cdk9 complex in basal and regulated transcription (review) by Napolitano, Giuliana, Majello, Barbara, Lania, Luigi

“…Cell division and proliferation of all eukaryotics must follow a genetic program, termed the cell cycle. To ensure proper progression through the cell cycle,…”
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Differential transcriptional regulation of c-myc promoter through the same DNA binding sites targeted by Sp1-like proteins by Majello, B, De Luca, P, Suske, G, Lania, L

“…Sp1 and Sp3 are closely related members of a gene family encoding proteins with very similar structural features. The zinc finger DNA binding domains of Sp1…”
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Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo by MAJELLO, B, NAPOLITANO, G, GIORDANO, A, LANIA, L

“…The CDK9 kinase in association with Cyclin T is a component of the transcription positive-acting complex pTEFb which facilitates the transition from abortive…”
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Inhibition of Tat activity by the HEXIM1 protein by Fraldi, Alessandro, Varrone, Francesca, Napolitano, Giuliana, Michels, Annemieke A, Majello, Barbara, Bensaude, Olivier, Lania, Luigi

“…The positive transcription elongation factor b (P-TEFb) composed by CDK9/CyclinT1 subunits is a dedicated co-factor of HIV transcriptional transactivator Tat…”
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A Novel Member of the BTB/POZ Family, PATZ, Associates with the RNF4 RING Finger Protein and Acts as a Transcriptional Repressor by Fedele, Monica, Benvenuto, Giovanna, Pero, Raffaela, Majello, Barbara, Battista, Sabrina, Lembo, Francesca, Vollono, Erminia, Day, Patricia M., Santoro, Massimo, Lania, Luigi, Bruni, Carmelo Bruno, Fusco, Alfredo, Chiariotti, Lorenzo

“…We have identified a novel human gene encoding a 59-kDa POZ-AT hook-zinc finger protein (PATZ) that interacts with RNF4, a mediator of androgen receptor…”
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