Increasing trend in enterococcal bacteraemia and vancomycin resistance in a tertiary care hospital in Croatia, 2017-2021

The epidemiology of enterococcal bacteraemia has changed worldwide and vancomycin-resistant enterococci increasingly cause healthcare-associated infections) with limited treatment options. Studies show heterogeneity among countries, regions and individual hospitals. We retrospectively analysed enter...

Full description

Saved in:

Bibliographic Details
Published in:	Infectious diseases (London, England) Vol. 55; no. 1; pp. 9 - 16
Main Authors:	Todorić, Zrinka, Majdandžić, Ivana, Keretić Kregar, Tea, Herljević, Zoran, Ćorić, Mario, Lešin, Joško, Kuliš, Tomislav, Mareković, Ivana
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 02-01-2023
Subjects:	Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - therapeutic use Bacteraemia Bacteremia - drug therapy Bacteremia - epidemiology Child Child, Preschool Cross Infection - drug therapy Cross Infection - epidemiology Enterococcus faecalis Enterococcus faecium Gram-Positive Bacterial Infections - drug therapy Gram-Positive Bacterial Infections - epidemiology haematology healthcare-associated infections Humans Infant Infant, Newborn intensive care unit Male Middle Aged Retrospective Studies Tertiary Care Centers Vancomycin Resistance Vancomycin-Resistant Enterococci Young Adult Bacteraemia haematology intensive care unit vancomycin-resistant enterococci healthcare-associated infections
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The epidemiology of enterococcal bacteraemia has changed worldwide and vancomycin-resistant enterococci increasingly cause healthcare-associated infections) with limited treatment options. Studies show heterogeneity among countries, regions and individual hospitals. We retrospectively analysed enterococcal bacteraemia with Enterococcus faecalis and E. faecium at the largest hospital in Croatia, University Hospital Centre Zagreb from January 2017 to December 2021. A total of 432 cases of enterococcal bacteraemia were identified with 256 (59.3%) due to E. faecalis and 176 (40.7%) to E. faecium. Enterococcal bacteraemia occurred more frequently in men (n = 270; 62.5%) and the median age of all patients was 62 years (IQR: 0-92). We found statistically significant increase in the incidence trend of bacteraemic episodes with an annual percent change of 20.9% (95% confidence interval 14.3 to 27.8; p = .002) predominantly due to an increase of E. faecalis bacteraemia. The majority of patients (362/432; 83.8%) had healthcare-associated infections and 38.0% (165/432) of patients were in the intensive care unit. The proportion of vancomycin-resistant enterococcal bacteraemia increased from 12.7% (n = 8/63) in 2017 to 25.7% (n = 29/113) in 2021, statistically significant increasing trend (p = .0455), mainly due to an increased proportion of vancomycin-resistant E. faecium (p = .0169). This is the first study describing the trends in enterococcal bacteraemia and vancomycin-resistance in enterococci in Croatia. We found a rising trend in enterococcal bacteraemia and in the proportion of vancomycin resistance and identified the most vulnerable patient groups, notably intensive care unit patients.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2374-4235 2374-4243
DOI:	10.1080/23744235.2022.2131901