Search Results - "Maizels, Rory J"

RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs by McClintock, Mark A, Dix, Carly I, Johnson, Christopher M, McLaughlin, Stephen H, Maizels, Rory J, Hoang, Ha Thi, Bullock, Simon L

“…Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles…”
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A protocol for time-resolved transcriptomics through metabolic labeling and combinatorial indexing by Maizels, Rory J., Snell, Daniel M., Briscoe, James

“…The snapshot nature of single-cell transcriptomics presents a challenge for studying the dynamics of gene expression. Metabolic labeling, where nascent RNA is…”
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A dynamical perspective: moving towards mechanism in single-cell transcriptomics by Maizels, Rory J

“…As the field of single-cell transcriptomics matures, research is shifting focus from phenomenological descriptions of cellular phenotypes to a mechanistic…”
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Single-cell transcriptome profiling of the human developing spinal cord reveals a conserved genetic programme with human-specific features by Rayon, Teresa, Maizels, Rory J, Barrington, Christopher, Briscoe, James

“…The spinal cord receives input from peripheral sensory neurons and controls motor output by regulating muscle innervating motor neurons. These functions are…”
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Active growth signaling promotes senescence and cancer cell sensitivity to CDK7 inhibition by Wilson, Gemma A, Vuina, Karla, Sava, Georgina, Huard, Caroline, Meneguello, Leticia, Coulombe-Huntington, Jasmin, Bertomeu, Thierry, Maizels, Rory J, Lauring, Josh, Kriston-Vizi, Janos, Tyers, Mike, Ali, Simak, Bertoli, Cosetta, de Bruin, Robertus A M

“…Tumor growth is driven by continued cellular growth and proliferation. Cyclin-dependent kinase 7's (CDK7) role in activating mitotic CDKs and global gene…”
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Reconstructing developmental trajectories using latent dynamical systems and time-resolved transcriptomics by Maizels, Rory J, Snell, Daniel M, Briscoe, James

“…The snapshot nature of single-cell transcriptomics presents a challenge for studying the dynamics of cell fate decisions. Metabolic labeling and splicing can…”
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