Search Results - "Maity, Soumya"

Lactate Elicits ER-Mitochondrial Mg2+ Dynamics to Integrate Cellular Metabolism by Daw, Cassidy C., Ramachandran, Karthik, Enslow, Benjamin T., Maity, Soumya, Bursic, Brian, Novello, Matthew J., Rubannelsonkumar, Cherubina S., Mashal, Ayah H., Ravichandran, Joel, Bakewell, Terry M., Wang, Weiwei, Li, Kang, Madaris, Travis R., Shannon, Christopher E., Norton, Luke, Kandala, Soundarya, Caplan, Jeffrey, Srikantan, Subramanya, Stathopulos, Peter B., Reeves, W. Brian, Madesh, Muniswamy

“…Mg2+ is the most abundant divalent cation in metazoans and an essential cofactor for ATP, nucleic acids, and countless metabolic enzymes. To understand how the…”
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The mitochondrial Ca2+ uniporter channel synergizes with fluid shear stress to induce mitochondrial Ca2+ oscillations by Patel, Akshar, Simkulet, Matthew, Maity, Soumya, Venkatesan, Manigandan, Matzavinos, Anastasios, Madesh, Muniswamy, Alevriadou, B. Rita

“…The mitochondrial calcium (Ca 2+ ) uniporter (MCU) channel is responsible for mitochondrial Ca 2+ influx. Its expression was found to be upregulated in…”
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Deacetylation of S6 kinase promotes high glucose–induced glomerular mesangial cell hypertrophy and matrix protein accumulation by Das, Falguni, Maity, Soumya, Ghosh-Choudhury, Nandini, Kasinath, Balakuntalam S., Ghosh Choudhury, Goutam

“…S6 kinase acts as a driver for renal hypertrophy and matrix accumulation, two key pathologic signatures of diabetic nephropathy. As a post-translational…”
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Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress by Madaris, Travis R., Venkatesan, Manigandan, Maity, Soumya, Stein, Miriam C., Vishnu, Neelanjan, Venkateswaran, Mridula K., Davis, James G., Ramachandran, Karthik, Uthayabalan, Sukanthathulse, Allen, Cristel, Osidele, Ayodeji, Stanley, Kristen, Bigham, Nicholas P., Bakewell, Terry M., Narkunan, Melanie, Le, Amy, Karanam, Varsha, Li, Kang, Mhapankar, Aum, Norton, Luke, Ross, Jean, Aslam, M. Imran, Reeves, W. Brian, Singh, Brij B., Caplan, Jeffrey, Wilson, Justin J., Stathopulos, Peter B., Baur, Joseph A., Madesh, Muniswamy

“…The most abundant cellular divalent cations, Mg2+ (mM) and Ca2+ (nM-μM), antagonistically regulate divergent metabolic pathways with several orders of…”
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SARS-CoV-2 infection enhances mitochondrial PTP complex activity to perturb cardiac energetics by Ramachandran, Karthik, Maity, Soumya, Muthukumar, Alagar R., Kandala, Soundarya, Tomar, Dhanendra, Abd El-Aziz, Tarek Mohamed, Allen, Cristel, Sun, Yuyang, Venkatesan, Manigandan, Madaris, Travis R., Chiem, Kevin, Truitt, Rachel, Vishnu, Neelanjan, Aune, Gregory, Anderson, Allen, Martinez-Sobrido, Luis, Yang, Wenli, Stockand, James D., Singh, Brij B., Srikantan, Subramanya, Reeves, W. Brian, Madesh, Muniswamy

“…SARS-CoV-2 is a newly identified coronavirus that causes the respiratory disease called coronavirus disease 2019 (COVID-19). With an urgent need for…”
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Modulation of the mitochondrial Ca2+ uniporter complex subunit expression by different shear stress patterns in vascular endothelial cells by Patel, Akshar, Pietromicca, Julia G., Venkatesan, Manigandan, Maity, Soumya, Bard, Jonathan E., Madesh, Muniswamy, Alevriadou, B. Rita

“…Mitochondrial calcium (mCa2+) uptake occurs via the Mitochondrial Ca2+ Uniporter (MCU) complex and plays a critical role in mitochondrial dynamics, mitophagy,…”
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Homoarginine ameliorates diabetic nephropathy independent of nitric oxide synthase‐3 by Wetzel, Michael D., Stanley, Kristen, Maity, Soumya, Madesh, Muniswamy, Bopassa, Jean C., Awad, Alaa S.

“…Recently we showed that homoarginine supplementation confers kidney protection in diabetic mouse models. In this study we tested whether the protective effect…”
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Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics by Nascimento Da Conceicao, Viviane, Sun, Yuyang, Ramachandran, Karthik, Chauhan, Arun, Raveendran, Amritha, Venkatesan, Manigandan, DeKumar, Bony, Maity, Soumya, Vishnu, Neelanjan, Kotsakis, George A., Worley, Paul F., Gill, Donald L., Mishra, Bibhuti B., Madesh, Muniswamy, Singh, Brij B.

“…Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified…”
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Selective inhibition of arginase-2 in endothelial cells but not proximal tubules reduces renal fibrosis by Wetzel, Michael D, Stanley, Kristen, Wang, Wei Wei, Maity, Soumya, Madesh, Muniswamy, Reeves, W Brian, Awad, Alaa S

“…Fibrosis is the final common pathway in the pathophysiology of most forms of chronic kidney disease (CKD). As treatment of renal fibrosis still remains largely…”
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TGFβ acts through PDGFRβ to activate mTORC1 via the Akt/PRAS40 axis and causes glomerular mesangial cell hypertrophy and matrix protein expression by Maity, Soumya, Das, Falguni, Kasinath, Balakuntalam S., Ghosh-Choudhury, Nandini, Ghosh Choudhury, Goutam

“…Interaction of transforming growth factor-β (TGFβ)-induced canonical signaling with the noncanonical kinase cascades regulates glomerular hypertrophy and…”
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Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease by Miyamoto, Satoshi, Zhang, Guanshi, Hall, David, Oates, Peter J., Maity, Soumya, Madesh, Muniswamy, Han, Xianlin, Sharma, Kumar

“…Exposure to chronic hyperglycemia because of diabetes mellitus can lead to development and progression of diabetic kidney disease (DKD). We recently reported…”
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Oncoprotein DJ-1 interacts with mTOR complexes to effect transcription factor Hif1α-dependent expression of collagen I (α2) during renal fibrosis by Das, Falguni, Ghosh-Choudhury, Nandini, Maity, Soumya, Kasinath, Balakuntalam S., Choudhury, Goutam Ghosh

“…Proximal tubular epithelial cells respond to transforming growth factor β (TGFβ) to synthesize collagen I (α2) during renal fibrosis. The oncoprotein DJ-1 has…”
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Polyaniline-(dinonylnapthyl disulphonic acid) hydrogel showing enhanced supercapacitor and photo-current performance by in situ growth of AgNPs by Basak, Udayan, Das, Arindam, Maity, Soumya, Chatterjee, Dhruba P., Nandi, Arun K.

“…Emulsion polymerization of aniline in presence of dinonylnapthyl disulphonic acid (DNNDSA) produces 3D-fibrillar network and invariant storage and loss modulus…”
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Inhibition of Endogenous Adenine Synthesis Ameliorates Kidney Injury in db/db Mice with Type 2 Diabetes: FR-PO375 by Lee, Hak Joo, Zhang, Guanshi, Montellano, Richard, Hejazi, Leila, Matta, Shane, Gao, Jingli, Maity, Soumya, Ghosh-Choudhury, Goutam, Kasinath, Balakuntalam S., Sharma, Kumar

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TGFβ instructs mTORC2 to activate PKCβII for increased TWIST1 expression in proximal tubular epithelial cell injury by Das, Falguni, Ghosh‐Choudhury, Nandini, Maity, Soumya, Kasinath, Balakuntalam S., Ghosh Choudhury, Goutam

“…The plasticity of proximal tubular epithelial cells in response to TGFβ contributes to the expression of TWIST1 to drive renal fibrosis. The mechanism of…”
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High glucose increases miR‐214 to power a feedback loop involving PTEN and the Akt/mTORC1 signaling axis by Maity, Soumya, Das, Falguni, Ghosh‐Choudhury, Nandini, Kasinath, Balakuntalam S., Ghosh Choudhury, Goutam

“…The mechanism of PTEN repression by high glucose in diabetic nephropathy is not known. Using proximal tubular cells, we show that inhibition of PI3 kinase/Akt…”
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Metabolomic and Transcriptomic Reveal Signature of Citrate Homeostasis in Diabetic Kidney Disease: FR-OR34 by Maity, Soumya, Limonte, Christine P., Valo, Erkka A., Zhang, Guanshi, Lee, Hak Joo, Pennathur, Subramaniam, Snell-Bergeon, Janet, Costacou, Tina, Rossing, Peter, Groop, Per-Henrik, Roy, Sourav, Sharma, Kumar

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Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity by Nemani, Neeharika, Dong, Zhiwei, Daw, Cassidy C, Madaris, Travis R, Ramachandran, Karthik, Enslow, Benjamin T, Rubannelsonkumar, Cherubina S, Shanmughapriya, Santhanam, Mallireddigari, Varshini, Maity, Soumya, SinghMalla, Pragya, Natarajanseenivasan, Kalimuthusamy, Hooper, Robert, Shannon, Christopher E, Tourtellotte, Warren G, Singh, Brij B, Reeves, W Brian, Sharma, Kumar, Norton, Luke, Srikantan, Subramanya, Soboloff, Jonathan, Madesh, Muniswamy

“…The tricarboxylic acid (TCA) cycle converts the end products of glycolysis and fatty acid β-oxidation into the reducing equivalents NADH and FADH Although…”
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Evaluation of Antioxidant Activity and Characterization of Phenolic Constituents of Phyllanthus amarus Root by Maity, Soumya, Chatterjee, Suchandra, Variyar, Prasad Shekhar, Sharma, Arun, Adhikari, Soumyakanti, Mazumder, Santasree

“…The antioxidant property of the 70% aqueous ethanol extract of Phyllanthus amarus roots and its ether-soluble, ethyl acetate-soluble, and aqueous fractions…”
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Female Protection Against Diabetic Kidney Disease Is Regulated by Kidney-Specific AMPK Activity by Lee, Hak Joo, Min, Liang, Gao, Jingli, Matta, Shane, Drel, Viktor, Saliba, Afaf, Tamayo, Ian, Montellano, Richard, Hejazi, Leila, Maity, Soumya, Xu, Guogang, Grajeda, Brian I, Roy, Sourav, Hallows, Kenneth R, Choudhury, Goutam Ghosh, Kasinath, Balakuntalam S, Sharma, Kumar

“…Reduced kidney AMPK activity is associated with nutrient stress-induced chronic kidney disease (CKD) in male mice. In contrast, female mice resist nutrient…”
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