Search Results - "Maitre, C"

Thermally triggered hydrogel injection into bovine intervertebral disc tissue explants induces differentiation of mesenchymal stem cells and restores mechanical function by Thorpe, A.A., Dougill, G, Vickers, L., Reeves, N.D., Sammon, C., Cooper, G., Le Maitre, C.L.

“…[Display omitted] We previously reported a synthetic Laponite® crosslinked pNIPAM-co-DMAc (L-pNIPAM-co-DMAc) hydrogel which promotes differentiation of…”
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TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc by Snuggs, J. W., Tessier, S., Bunning, R. A. B., Shapiro, I. M., Risbud, M. V., Le Maitre, C. L.

“…The central region of the intervertebral disc (IVD) is rich in proteoglycans, leading to a hyperosmotic environment, which fluctuates with daily loading. The…”
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Thermally triggered injectable hydrogel, which induces mesenchymal stem cell differentiation to nucleus pulposus cells: Potential for regeneration of the intervertebral disc by Thorpe, A.A., Boyes, V.L., Sammon, C., Le Maitre, C.L.

“…In vitro differentiation of MSCs into NP-like cells, following incorporation into pNIPAM-DMAc-Laponite® hydrogel cultured under 5% O2 for 6weeks with increased…”
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Investigation of the role of IL-1 and TNF in matrix degradation in the intervertebral disc by Hoyland, J. A., Le Maitre, C., Freemont, A. J.

“…Objective. To establish if IL-1 or TNF regulates matrix degradation in the non-degenerate or degenerate intervertebral disc (IVD). Methods. In situ zymography…”
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An assessment of the effectiveness of a large, national-scale invasive alien plant control strategy in South Africa by van Wilgen, Brian W., Forsyth, Greg G., Le Maitre, David C., Wannenburgh, Andrew, Kotzé, Johann D.F., van den Berg, Elna, Henderson, Lesley

“…► South Africa’s alien plant control program has operated for 15years. ► Manual control had little effect and invasion by priority species has increased. ► The…”
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Use of hydrogel scaffolds to develop an in vitro 3D culture model of human intestinal epithelium by Dosh, R.H., Essa, A., Jordan-Mahy, N., Sammon, C., Le Maitre, C.L.

“…[Display omitted] The human intestinal cell lines: Caco-2 and HT29-MTX cells have been used extensively in 2D and 3D cell cultures as simple models of the…”
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Potential roles of cytokines and chemokines in human intervertebral disc degeneration: interleukin-1 is a master regulator of catabolic processes by Phillips, K.L.E, Cullen, K, Chiverton, N, Michael, A.L.R, Cole, A.A, Breakwell, L.M, Haddock, G, Bunning, R.A.D, Cross, A.K, Le Maitre, C.L

“…Summary Objective These studies investigated cytokine and chemokine receptor profiles in nucleus pulposus (NP) cells, and the effects of receptor stimulation…”
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Ex vivo intervertebral disc cultures: degeneration-induction methods and their implications for clinical translation by Salzer, E, Schmitz, T C, Mouser, V Hm, Vernengo, A, Gantenbein, B, Jansen, J U, Neidlinger-Wilke, C, Wilke, H-J, Grad, S, Le Maitre, C L, Tryfonidou, M A, Ito, K

“…Because low back pain is frequently a result of intervertebral disc degeneration (IVDD), strategies to regenerate or repair the IVD are currently being…”
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Prosopis: a global assessment of the biogeography, benefits, impacts and management of one of the world's worst woody invasive plant taxa by Shackleton, Ross T., Le Maitre, David C., Pasiecznik, Nick M., Richardson, David M.

“…Taxa from the genus Prosopis are widespread invasive aliens across the globe. Numerous species have contentious issues surrounding them as they provide both…”
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Hydroxyapatite nanoparticle injectable hydrogel scaffold to support osteogenic differentiation of human mesenchymal stem cells by Thorpe, A A, Creasey, S, Sammon, C, Le Maitre, C L

“…Bone loss associated with degenerative disease and trauma is a clinical problem increasing with the aging population. Thus, effective bone augmentation…”
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Osmotic adaptation of nucleus pulposus cells: the role of aquaporin 1, aquaporin 4 and transient receptor potential vanilloid 4 by Snuggs, J W, Bunning, R Ad, Le Maitre, C L

“…The microenvironment of the nucleus pulposus is hyperosmotic and fluctuates diurnally due to mechanical loading. Changes in extracellular osmolality result in…”
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Estimates of the impacts of invasive alien plants on water flows in South Africa by Forsyth, Greg G., Le Maitre, David C., Gush, Mark B., Dzikiti, Sebinasi

“…The adverse impacts of alien plant invasions on water flows have been a prime motivation for South Africa's Working for Water Programme. The approach used in…”
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Matrix synthesis and degradation in human intervertebral disc degeneration by Le Maitre, C L, Pockert, A, Buttle, D J, Freemont, A J, Hoyland, J A

“…Degeneration of the intervertebral disc has been implicated in chronic low back pain. Type II collagen and proteoglycan (predominantly aggrecan) content is…”
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Modelling the catabolic environment of the moderately degenerated disc with a caprine ex vivo loaded disc culture system by Rustenburg, C Me, Snuggs, J W, Emanuel, K S, Thorpe, A, Sammon, C, Le Maitre, C L, Smit, T H

“…Low-back pain affects 80 % of the world population at some point in their lives and 40 % of the cases are attributed to intervertebral disc (IVD) degeneration…”
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Notochordal cell-derived matrix inhibits MAPK signaling in the degenerative disc environment by Laagland, LT, Bach, FC, Riemers, FM, Erdmann, G, Braun, TS, van den Akker, GGH, Schmitz, TC, Creemers, LB, Sachse, C, Le Maitre, CL, Welting, TJM, Ito, K, Templin, MF, Tryfonidou, MA

“…Chronic low back pain is often caused by intervertebral disc (IVD) degeneration. Preceding this degenerative process, the main cellular phenotype in the…”
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Citalopram in vitro metabolism in a beagle dog: A role for CYP2D15 in the production of toxic didesmethylcitalopram? by Rochat, B, Paus, E, Maitre, C, Baumann, P

“…After administration of the serotonergic antidepressant citalopram (CIT) to Beagle dogs, the dogs may experience severe convulsive attacks in relation to the…”
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The prioritisation of invasive alien plant control projects using a multi-criteria decision model informed by stakeholder input and spatial data by Forsyth, G.G., Le Maitre, D.C., O'Farrell, P.J., van Wilgen, B.W.

“…Invasions by alien plants are a significant threat to the biodiversity and functioning of ecosystems and the services they provide. The South African Working…”
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Natural hazards in a changing world: a case for ecosystem-based management by Nel, Jeanne L, Le Maitre, David C, Nel, Deon C, Reyers, Belinda, Archibald, Sally, van Wilgen, Brian W, Forsyth, Greg G, Theron, Andre K, O'Farrell, Patrick J, Kahinda, Jean-Marc Mwenge, Engelbrecht, Francois A, Kapangaziwiri, Evison, van Niekerk, Lara, Barwell, Laurie

“…Communities worldwide are increasingly affected by natural hazards such as floods, droughts, wildfires and storm-waves. However, the causes of these increases…”
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The biodiversity hotspot as evolutionary hot-bed: spectacular radiation of Erica in the Cape Floristic Region by Pirie, M D, Oliver, E G H, Mugrabi de Kuppler, A, Gehrke, B, Le Maitre, N C, Kandziora, M, Bellstedt, D U

“…The disproportionate species richness of the world's biodiversity hotspots could be explained by low extinction (the evolutionary "museum") and/or high…”
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Floral Color, Anthocyanin Synthesis Gene Expression and Control in Cape Erica Species by Le Maitre, N C, Pirie, Michael David, Bellstedt, Dirk U

“…The Cape Floristic Region (CFR) is a biodiversity hotspot, recognized globally for its unusually high levels of endemism. The origins of this biodiversity are…”
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