Search Results - "Maitland, R."

Noncanonical functions of Ku may underlie essentiality in human cells by Kelly, Rachel D., Parmar, Gursimran, Bayat, Laila, Maitland, Matthew E. R., Lajoie, Gilles A., Edgell, David R., Schild-Poulter, Caroline

“…The Ku70/80 heterodimer is a key player in non-homologous end-joining DNA repair but is involved in other cellular functions like telomere regulation and…”
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Behavioural intervention to promote the uptake of planned care in urgent dental care attenders: study protocol for the RETURN randomised controlled trial by Harris, R, Lowers, V, Hulme, C, Burnside, G, Best, A, Clarkson, J E, Cooke, R, Van Der Zande, M, Maitland, R

“…People with disadvantaged backgrounds are less likely to visit the dentist for planned care, even though they have disproportionately poorer oral health. They…”
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Structural and Functional Insights into GID/CTLH E3 Ligase Complexes by Maitland, Matthew E R, Lajoie, Gilles A, Shaw, Gary S, Schild-Poulter, Caroline

“…Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate receptor subunits with a single catalytic center. Small molecules…”
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Prediction of gestational diabetes in obese pregnant women from the UK Pregnancies Better Eating and Activity (UPBEAT) pilot trial by Maitland, R. A., Seed, P. T., Briley, A. L., Homsy, M., Thomas, S., Pasupathy, D., Robson, S. C., Nelson, S. M., Sattar, N., Poston, L.

“…Aim To examine the prediction of gestational diabetes in obese women using routine clinical measures and measurement of biomarkers related to insulin…”
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Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex by Salemi, Louisa M, Maitland, Matthew E R, Yefet, Eyal R, Schild-Poulter, Caroline

“…Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase that promotes many cellular processes that lead to cell transformation and tumour…”
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Regulation of c-Raf Stability through the CTLH Complex by McTavish, Christina J, Bérubé-Janzen, Wesley, Wang, Xu, Maitland, Matthew E R, Salemi, Louisa M, Hess, David A, Schild-Poulter, Caroline

“…c-Raf is a central component of the extracellular signal-regulated kinase (ERK) pathway which is implicated in the development of many cancer types. RanBPM…”
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Cell signalling pathway regulation by RanBPM: molecular insights and disease implications by Salemi, Louisa M., Maitland, Matthew E. R., McTavish, Christina J., Schild-Poulter, Caroline

“…RanBPM (Ran-binding protein M, also called RanBP9) is an evolutionarily conserved, ubiquitous protein which localizes to both nucleus and cytoplasm. RanBPM has…”
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Severe hypertriglyceridaemia in Type 2 diabetes mellitus: beneficial effect of continuous insulin infusion by Henderson, S R, Maitland, R, Mustafa, O G, Miell, J, Crook, M A, Kottegoda, S R

“…Severe hypertriglyceridaemia is a recognized complication of Type 2 diabetes mellitus (T2DM); however, there is no consensus on acute management despite the…”
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A chemical probe to modulate human GID4 Pro/N-degron interactions by Owens, Dominic D. G., Maitland, Matthew E. R., Khalili Yazdi, Aliakbar, Song, Xiaosheng, Reber, Viviane, Schwalm, Martin P., Machado, Raquel A. C., Bauer, Nicolas, Wang, Xu, Szewczyk, Magdalena M., Dong, Cheng, Dong, Aiping, Loppnau, Peter, Calabrese, Matthew F., Dowling, Matthew S., Lee, Jisun, Montgomery, Justin I., O’Connell, Thomas N., Subramanyam, Chakrapani, Wang, Feng, Adamson, Ella C., Schapira, Matthieu, Gstaiger, Matthias, Knapp, Stefan, Vedadi, Masoud, Min, Jinrong, Lajoie, Gilles A., Barsyte-Lovejoy, Dalia, Owen, Dafydd R., Schild-Poulter, Caroline, Arrowsmith, Cheryl H.

“…The C-terminal to LisH (CTLH) complex is a ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via its substrate receptor Glucose-Induced…”
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Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo by Lackie, Rachel E., de Miranda, Aline S., Lim, Mei Peng, Novikov, Vladislav, Madrer, Nimrod, Karunatilleke, Nadun C., Rutledge, Benjamin S., Tullo, Stephanie, Brickenden, Anne, Maitland, Matthew E. R., Greenberg, David, Gallino, Daniel, Luo, Wen, Attaran, Anoosha, Shlaifer, Irina, Del Cid Pellitero, Esther, Schild-Poulter, Caroline, Durcan, Thomas M., Fon, Edward A., Duennwald, Martin, Beraldo, Flavio H., Chakravarty, M. Mallar, Bussey, Timothy J., Saksida, Lisa M., Soreq, Hermona, Choy, Wing-Yiu, Prado, Vania F., Prado, Marco A. M.

“…The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to misfolding and aggregation in synucleinopathies, such as Parkinson’s…”
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Analysis of Amblyomma surveillance data in the Caribbean: Lessons for future control programmes by Ahoussou, S., Lancelot, R., Sanford, B., Porphyre, T., Bartlette-Powell, P., Compton, E., Henry, L., Maitland, R., Lloyd, R., Mattioli, R., Chavernac, D., Stachurski, F., Martinez, D., Meyer, D.F., Vachiery, N., Pegram, R., Lefrançois, T.

“…Amblyomma variegatum, the Tropical Bont Tick (TBT), is the principal vector of heartwater and is associated with dermatophilosis, major causes of losses in…”
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1840 Expanding undergraduate medical students' understanding of frailty by Bellhouse, E, Maitland, R, Alexander, R, Colquhoun, K

“…Abstract Introduction In response to the recent publication of the new British Geriatrics Society undergraduate medical curriculum (1), the medical education…”
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Taking training into your own hands by Price, HC, George, J, Wilmot, EG, Maitland, R, Knox, R, Atkin, M, Choudhary, P

“…The Young Diabetologists’ Forum (YDF) is a group designed and run by specialist trainees in endocrinology and diabetes that aims to provide high quality…”
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Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis by Maitland, Matthew E. R., Kuljanin, Miljan, Wang, Xu, Lajoie, Gilles A., Schild‐Poulter, Caroline

“…Ubiquitination is an essential post‐translational modification that regulates protein stability or function. Its substrate specificity is dictated by various…”
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Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex by Onea, Gabriel, Maitland, Matthew E. R., Wang, Xu, Lajoie, Gilles A., Schild-Poulter, Caroline

“…ABSTRACT The C-terminal to LisH (CTLH) complex is a newly discovered multi-subunit E3 ubiquitin ligase and its cellular functions are poorly characterized…”
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The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation by Maitland, Matthew E. R., Onea, Gabriel, Chiasson, Christopher A., Wang, Xu, Ma, Jun, Moor, Sarah E., Barber, Kathryn R., Lajoie, Gilles A., Shaw, Gary S., Schild-Poulter, Caroline

“…The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of the yeast Gid E3 ubiquitin ligase complex. In this study, we investigated the…”
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Recruitment of FBXO22 for targeted degradation of NSD2 by Nie, David Y, Tabor, John R, Li, Jianping, Kutera, Maria, St-Germain, Jonathan, Hanley, Ronan P, Wolf, Esther, Paulakonis, Ethan, Kenney, Tristan M G, Duan, Shili, Shrestha, Suman, Owens, Dominic D G, Maitland, Matthew E R, Pon, Ailing, Szewczyk, Magdalena, Lamberto, Anthony Joseph, Menes, Michael, Li, Fengling, Penn, Linda Z, Barsyte-Lovejoy, Dalia, Brown, Nicholas G, Barsotti, Anthony M, Stamford, Andrew W, Collins, Jon L, Wilson, Derek J, Raught, Brian, Licht, Jonathan D, James, Lindsey I, Arrowsmith, Cheryl H

“…Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of…”
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Taking accurate measure by Maitland, R I

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Direct posterior composite failures by Maitland, R I

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Lack of confidence among trainee doctors in the management of diabetes: the Trainees Own Perception of Delivery of Care (TOPDOC) Diabetes Study by GEORGE, J. T, WARRINER, D, MCGRANE, D. J, ROZARIO, K. S, PRICE, H. C, WILMOT, E. G, KAR, P, STRATTON, I. M, JUDE, E. B, MCKAY, G. A

“…There is an increased prevalence of diabetes. Doctors in training, irrespective of specialty, will have patients with diabetes under their care. To determine…”
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