Search Results - "Maitland, Matthew"

Proteomic analysis of ubiquitination substrates reveals a CTLH E3 ligase complex‐dependent regulation of glycolysis by Maitland, Matthew E. R., Kuljanin, Miljan, Wang, Xu, Lajoie, Gilles A., Schild‐Poulter, Caroline

“…Ubiquitination is an essential post‐translational modification that regulates protein stability or function. Its substrate specificity is dictated by various…”
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Noncanonical functions of Ku may underlie essentiality in human cells by Kelly, Rachel D., Parmar, Gursimran, Bayat, Laila, Maitland, Matthew E. R., Lajoie, Gilles A., Edgell, David R., Schild-Poulter, Caroline

“…The Ku70/80 heterodimer is a key player in non-homologous end-joining DNA repair but is involved in other cellular functions like telomere regulation and…”
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The mammalian CTLH complex is an E3 ubiquitin ligase that targets its subunit muskelin for degradation by Maitland, Matthew E. R., Onea, Gabriel, Chiasson, Christopher A., Wang, Xu, Ma, Jun, Moor, Sarah E., Barber, Kathryn R., Lajoie, Gilles A., Shaw, Gary S., Schild-Poulter, Caroline

“…The multi-subunit C-terminal to LisH (CTLH) complex is the mammalian homologue of the yeast Gid E3 ubiquitin ligase complex. In this study, we investigated the…”
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Distinct nuclear and cytoplasmic assemblies and interactomes of the mammalian CTLH E3 ligase complex by Onea, Gabriel, Maitland, Matthew E. R., Wang, Xu, Lajoie, Gilles A., Schild-Poulter, Caroline

“…The C-terminal to LisH (CTLH) complex is a newly discovered multi-subunit E3 ubiquitin ligase and its cellular functions are poorly characterized. Although…”
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A chemical probe to modulate human GID4 Pro/N-degron interactions by Owens, Dominic D. G., Maitland, Matthew E. R., Khalili Yazdi, Aliakbar, Song, Xiaosheng, Reber, Viviane, Schwalm, Martin P., Machado, Raquel A. C., Bauer, Nicolas, Wang, Xu, Szewczyk, Magdalena M., Dong, Cheng, Dong, Aiping, Loppnau, Peter, Calabrese, Matthew F., Dowling, Matthew S., Lee, Jisun, Montgomery, Justin I., O’Connell, Thomas N., Subramanyam, Chakrapani, Wang, Feng, Adamson, Ella C., Schapira, Matthieu, Gstaiger, Matthias, Knapp, Stefan, Vedadi, Masoud, Min, Jinrong, Lajoie, Gilles A., Barsyte-Lovejoy, Dalia, Owen, Dafydd R., Schild-Poulter, Caroline, Arrowsmith, Cheryl H.

“…The C-terminal to LisH (CTLH) complex is a ubiquitin ligase complex that recognizes substrates with Pro/N-degrons via its substrate receptor Glucose-Induced…”
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Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo by Lackie, Rachel E., de Miranda, Aline S., Lim, Mei Peng, Novikov, Vladislav, Madrer, Nimrod, Karunatilleke, Nadun C., Rutledge, Benjamin S., Tullo, Stephanie, Brickenden, Anne, Maitland, Matthew E. R., Greenberg, David, Gallino, Daniel, Luo, Wen, Attaran, Anoosha, Shlaifer, Irina, Del Cid Pellitero, Esther, Schild-Poulter, Caroline, Durcan, Thomas M., Fon, Edward A., Duennwald, Martin, Beraldo, Flavio H., Chakravarty, M. Mallar, Bussey, Timothy J., Saksida, Lisa M., Soreq, Hermona, Choy, Wing-Yiu, Prado, Vania F., Prado, Marco A. M.

“…The predominantly pre-synaptic intrinsically disordered protein α-synuclein is prone to misfolding and aggregation in synucleinopathies, such as Parkinson’s…”
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Regulation of c-Raf Stability through the CTLH Complex by McTavish, Christina J, Bérubé-Janzen, Wesley, Wang, Xu, Maitland, Matthew E R, Salemi, Louisa M, Hess, David A, Schild-Poulter, Caroline

“…c-Raf is a central component of the extracellular signal-regulated kinase (ERK) pathway which is implicated in the development of many cancer types. RanBPM…”
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Recruitment of FBXO22 for targeted degradation of NSD2 by Nie, David Y., Tabor, John R., Li, Jianping, Kutera, Maria, St-Germain, Jonathan, Hanley, Ronan P., Wolf, Esther, Paulakonis, Ethan, Kenney, Tristan M. G., Duan, Shili, Shrestha, Suman, Owens, Dominic D. G., Maitland, Matthew E. R., Pon, Ailing, Szewczyk, Magdalena, Lamberto, Anthony Joseph, Menes, Michael, Li, Fengling, Penn, Linda Z., Barsyte-Lovejoy, Dalia, Brown, Nicholas G., Barsotti, Anthony M., Stamford, Andrew W., Collins, Jon L., Wilson, Derek J., Raught, Brian, Licht, Jonathan D., James, Lindsey I., Arrowsmith, Cheryl H.

“…Targeted protein degradation (TPD) is an emerging therapeutic strategy that would benefit from new chemical entities with which to recruit a wider variety of…”
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Inhibition of HDAC6 activity through interaction with RanBPM and its associated CTLH complex by Salemi, Louisa M, Maitland, Matthew E R, Yefet, Eyal R, Schild-Poulter, Caroline

“…Histone deacetylase 6 (HDAC6) is a microtubule-associated deacetylase that promotes many cellular processes that lead to cell transformation and tumour…”
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Structural and Functional Insights into GID/CTLH E3 Ligase Complexes by Maitland, Matthew E R, Lajoie, Gilles A, Shaw, Gary S, Schild-Poulter, Caroline

“…Multi-subunit E3 ligases facilitate ubiquitin transfer by coordinating various substrate receptor subunits with a single catalytic center. Small molecules…”
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Cell signalling pathway regulation by RanBPM: molecular insights and disease implications by Salemi, Louisa M., Maitland, Matthew E. R., McTavish, Christina J., Schild-Poulter, Caroline

“…RanBPM (Ran-binding protein M, also called RanBP9) is an evolutionarily conserved, ubiquitous protein which localizes to both nucleus and cytoplasm. RanBPM has…”
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Therapeutic Discovery for Chromatin Complexes: Where Do We Stand? by Owens, Dominic D.G, Maitland, Matthew E.R, Arrowsmith, Cheryl H, Barsyte-Lovejoy, Dalia

“…In this review, we explore the current landscape of preclinical and clinical therapeutics targeting epigenetic complexes in cancer, focusing on targets with…”
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Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice by Gould, Nathaniel L, Scherer, Gila R, Carvalho, Silvia, Shurrush, Khriesto, Kayyal, Haneen, Edry, Efrat, Elkobi, Alina, David, Orit, Foqara, Maria, Thakar, Darshit, Pavesi, Tommaso, Sharma, Vijendra, Walker, Matthew, Maitland, Matthew, Dym, Orly, Albeck, Shira, Peleg, Yoav, Germain, Nicolas, Babaev, Ilana, Sharir, Haleli, Lalzar, Maya, Shklyar, Boris, Hazut, Neta, Khamaisy, Mohammad, Lévesque, Maxime, Lajoie, Gilles, Avoli, Massimo, Amitai, Gabriel, Lefker, Bruce, Subramanyam, Chakrapani, Shilton, Brian, Barr, Haim, Rosenblum, Kobi

“…Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer's disease (AD)…”
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Identifying Cytoplasmic and Nuclear C‐Terminal to LisH (CTLH) Complex Interactors Using High‐Throughput Proteomics by Onea, Gabriel, Maitland, Matthew, Lajoie, Gilles, Schild‐Poulter, Caroline

“…The C‐terminal to LisH (CTLH) complex is a tumour‐suppressive E3 Really Interesting New Gene (RING) ubiquitin ligase that regulates intracellular signaling…”
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Uncovering the Ubiquitin Ligase Activity and Substrates of the Human C-Terminal to LisH (CTLH) Complex by Maitland, Matthew E.R

“…Ubiquitination is the transfer of a ubiquitin molecule to protein substrates by the sequential actions of E1 activating enzymes, E2 conjugating enzymes, and E3…”
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The Role of Thymine DNA Glycosylase (Tdg) and DNA Demethylation in TGF Beta Signaling by Maitland, Matthew E. R

“…Prompted by findings that TGFβ stimulates thymine DNA glycosylase (TDG) dependent rapid DNA demethylation and activation of the CDKN2B gene, I investigated the…”
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