Search Results - "Maitland, A."

Reducing the inherent auto-inhibitory interaction within the pegRNA enhances prime editing efficiency by Ponnienselvan, Karthikeyan, Liu, Pengpeng, Nyalile, Thomas, Oikemus, Sarah, Maitland, Stacy A, Lawson, Nathan D, Luban, Jeremy, Wolfe, Scot A

“…Abstract Prime editing systems have enabled the incorporation of precise edits within a genome without introducing double strand breaks. Previous studies…”
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SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase by Hou, Xiuyun, Xu, Shanqin, Maitland-Toolan, Karlene A., Sato, Kaori, Jiang, Bingbing, Ido, Yasuo, Lan, Fan, Walsh, Kenneth, Wierzbicki, Michel, Verbeuren, Tony J., Cohen, Richard A., Zang, Mengwei

“…Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase. Because we have recently defined AMPK activation as a key mechanism for…”
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Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice by MENGWEI ZANG, SHANQIN XU, MAITLAND-TOOLAN, Karlene A, ZUCCOLLO, Adriana, XIUYUN HOU, BINGBING JIANG, WIERZBICKI, Michel, VERBEUREN, Tony J, COHEN, Richard A

“…Polyphenols Stimulate AMP-Activated Protein Kinase, Lower Lipids, and Inhibit Accelerated Atherosclerosis in Diabetic LDL Receptor–Deficient Mice Mengwei Zang…”
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Ex vivo culture resting time impacts transplantation outcomes of genome-edited human hematopoietic stem and progenitor cells in xenograft mouse models by Demirci, Selami, Khan, Muhammad B.N., Hinojosa, Gabriela, Le, Anh, Leonard, Alexis, Essawi, Khaled, Gudmundsdottir, Bjorg, Liu, Xiong, Zeng, Jing, Inam, Zaina, Chu, Rebecca, Uchida, Naoya, Araki, Daisuke, London, Evan, Butt, Henna, Maitland, Stacy A., Bauer, Daniel E., Wolfe, Scot A., Larochelle, Andre, Tisdale, John F.

“…Ex vivo resting culture is a standard procedure following genome editing in hematopoietic stem and progenitor cells (HSPCs). However, prolonged culture may…”
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Early‐life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta‐analysis by Ahmadizar, F., Vijverberg, S. J. H., Arets, H. G. M., Boer, A., Lang, J. E., Garssen, J., Kraneveld, A., Maitland‐van der Zee, A. H.

“…This study systematically reviewed and quantified the relationship between exposure to antibiotics during the first 2 years of life and the risk of…”
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Pharmacogenetics: From Bench to Byte- An Update of Guidelines by Swen, JJ, Nijenhuis, M, Boer, A, Grandia, L, Maitland‐van der Zee, AH, Mulder, H, Rongen, GAPJM, Schaik, RHN, Schalekamp, T, Touw, DJ, Weide, J, Wilffert, B, Deneer, VHM, Guchelaar, H‐J

“…Currently, there are very few guidelines linking the results of pharmacogenetic tests to specific therapeutic recommendations. Therefore, the Royal Dutch…”
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Phenotype Standardization for Statin-Induced Myotoxicity by Alfirevic, A, Neely, D, Armitage, J, Chinoy, H, Cooper, R G, Laaksonen, R, Carr, D F, Bloch, K M, Fahy, J, Hanson, A, Yue, Q-Y, Wadelius, M, Maitland-van Der Zee, A H, Voora, D, Psaty, B M, Palmer, C N A, Pirmohamed, M

“…Statins are widely used lipid‐lowering drugs that are effective in reducing cardiovascular disease risk. Although they are generally well tolerated, they can…”
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Prevalence of and factors associated with adult-onset asthma in different ethnic groups: The HELIUS study by Aarab, R., Vijverberg, S.J.H., Prins, M., Snijder, M.B., van Ree, R., Fokkens, W.J., Zwinderman, A.H., Bel, E.H.D., Maitland van der Zee, A.H.

“…Little is known about adult-onset asthma in different ethnic groups. The aim of this study was to examine ethnic differences in the prevalence of adult-onset…”
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Crosstalk between corepressor NRIP1 and cAMP signaling on adipocyte thermogenic programming by Tsagkaraki, Emmanouela, Guilherme, Adilson, Nicoloro, Sarah M., Kelly, Mark, Lifshitz, Lawrence M., Wang, Hui, Min, Kyounghee, Rowland, Leslie A., Santos, Kaltinaitis B., Wetoska, Nicole, Friedline, Randall H., Maitland, Stacy A., Chen, Min, Weinstein, Lee S., Wolfe, Scot A., Kim, Jason K., Czech, Michael P.

“…Nuclear receptor interacting protein 1 (NRIP1) suppresses energy expenditure via repression of nuclear receptors, and its depletion markedly elevates uncoupled…”
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Patients Benefit From Genetics-Guided Coumarin Anticoagulant Therapy by van der Zee, A H Maitland, Daly, A K, Kamali, F, Manolopoulous, V G, Verhoef, T I, Wadelius, M, de Boer, A, Pirmohamed, M

“…Observational studies have overwhelmingly shown that variants in the genes CYP2C9 and VKORC1 are significant determinants of individual dose of coumarin…”
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Prediction of gestational diabetes in obese pregnant women from the UK Pregnancies Better Eating and Activity (UPBEAT) pilot trial by Maitland, R. A., Seed, P. T., Briley, A. L., Homsy, M., Thomas, S., Pasupathy, D., Robson, S. C., Nelson, S. M., Sattar, N., Poston, L.

“…Aim To examine the prediction of gestational diabetes in obese women using routine clinical measures and measurement of biomarkers related to insulin…”
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Pre-existing immunity does not impair the engraftment of CRISPR-Cas9-edited cells in rhesus macaques conditioned with busulfan or radiation by Essawi, Khaled, Hakami, Waleed, Naeem Khan, Muhammad Behroz, Martin, Reid, Zeng, Jing, Chu, Rebecca, Uchida, Naoya, Bonifacino, Aylin C., Krouse, Allen E., Linde, Nathaniel S., Donahue, Robert E., Blobel, Gerd A., Gerdemann, Ulrike, Kean, Leslie S., Maitland, Stacy A., Wolfe, Scot A., Metais, Jean-Yves, Gottschalk, Stephen, Bauer, Daniel E., Tisdale, John F., Demirci, Selami

“…CRISPR-Cas9-based therapeutic genome editing approaches hold promise to cure a variety of human diseases. Recent findings demonstrate pre-existing immunity for…”
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CARDIAC SURGICAL TRAINING THROUGH LOW-FIDELITY SIMULATION by Holloway, D, Kidd, B, Quantz, M, Maitland, A

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FCER2 T2206C variant associated with chronic symptoms and exacerbations in steroid‐treated asthmatic children by Koster, E. S., Maitland‐van der Zee, A.‐H., Tavendale, R., Mukhopadhyay, S., Vijverberg, S. J. H., Raaijmakers, J. A. M., Palmer, C. N. A.

“…To cite this article: Koster ES, Maitland‐van der Zee A‐H, Tavendale R, Mukhopadhyay S, Vijverberg SJH, Raaijmakers JAM, Palmer CNA. FCER2 T2206C variant…”
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NOACs replace VKA as preferred oral anticoagulant among new patients: a drug utilization study in 560 pharmacies in The Netherlands by van den Heuvel, J M, Hövels, A M, Büller, H R, Mantel-Teeuwisse, A K, de Boer, A, Maitland-van der Zee, A H

“…In 2012, around 400.000 patients in the Netherlands were treated with Vitamin K Antagonists (VKA) for thromboembolic diseases. Since 2011, non-VKA oral…”
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Three-minute constant rate step test for detecting exertional dyspnea relief after bronchodilation in COPD by Borel, Benoit, Wilkinson-Maitland, Courtney A, Hamilton, Alan, Bourbeau, Jean, Perrault, Hélène, Jensen, Dennis, Maltais, François

“…The aim of this study was to evaluate the responsiveness of the 3-minute constant rate step test (3-MST) to detect the relief of exertional dyspnea…”
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17q21 variant increases the risk of exacerbations in asthmatic children despite inhaled corticosteroids use by Farzan, N., Vijverberg, S. J., Hernandez‐Pacheco, N., Bel, E. H. D., Berce, V., Bønnelykke, K., Bisgaard, H., Burchard, E. G., Canino, G., Celedón, J. C., Chew, F. T., Chiang, W. C., Cloutier, M. M., Forno, E., Francis, B., Hawcutt, D. B., Herrera‐Luis, E., Kabesch, M., Karimi, L., Melén, E., Mukhopadhyay, S., Merid, S. K., Palmer, C. N., Pino‐Yanes, M., Pirmohamed, M., Potočnik, U., Repnik, K., Schieck, M., Sevelsted, A., Sio, Y. Y., Smyth, R. L., Soares, P., Söderhäll, C., Tantisira, K. G., Tavendale, R., Tse, S. M., Turner, S., Verhamme, K. M., Maitland‐van der Zee, A.‐H.

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The Thromboxane Receptor Antagonist S18886 Attenuates Renal Oxidant Stress and Proteinuria in Diabetic Apolipoprotein E-Deficient Mice by Xu, Shanqin, Jiang, Bingbing, Maitland, Karlene A, Bayat, Hossein, Gu, Jiali, Nadler, Jerry L, Corda, Stefano, Lavielle, Gilbert, Verbeuren, Tony J, Zuccollo, Adriana, Cohen, Richard A

“…The Thromboxane Receptor Antagonist S18886 Attenuates Renal Oxidant Stress and Proteinuria in Diabetic Apolipoprotein E-Deficient Mice Shanqin Xu 1 , Bingbing…”
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Biomarkers of therapy responsiveness in asthma: pitfalls and promises by Vijverberg, S. J. H., Koenderman, L., Koster, E. S., van der Ent, C. K., Raaijmakers, J. A. M., Maitland-van der Zee, A.-H.

“…Summary Asthma is one of the most common chronic diseases worldwide. There is a large inter‐individual variability in response to asthma treatment. Most…”
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Glucose-6-Phosphate Dehydrogenase Deficiency Decreases Vascular Superoxide and Atherosclerotic Lesions in Apolipoprotein E−/− Mice by Matsui, Reiko, Xu, Shanqin, Maitland, Karlene A, Mastroianni, Roberto, Leopold, Jane A, Handy, Diane E, Loscalzo, Joseph, Cohen, Richard A

“…OBJECTIVE—Glucose-6-phosphate dehydrogenase (G6PD) is a key enzyme in the pentose phosphate pathway that is a major source of cellular NADPH. The purpose of…”
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