Synthesis of Benzothiazole and Pyrimidine Based Fused Derivatives and Their Biological Evaluation

Synthesis of Benzothiazole and Pyrimidine Based Fused Derivatives and Their Biological Evaluation

In the present study a series of ethyl 4-(substituted)-2-methyl-4 H -benzo[4,5]thiazolo[3,2- a ]pyrimidine-3-carboxylate and ethyl 4-(substituted)-8-methoxy-2-methyl-4 H -benzo[4,5]thiazolo[3,2- a ]pyrimidine-3-carboxylate have been synthesized and evaluated for their preliminary antibacterial, anti...

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Bibliographic Details
Published in:Russian journal of organic chemistry Vol. 59; no. Suppl 1; pp. S140 - S149
Main Authors: Patel, Navin B., Maisuria, Pratik N., Gujarati, Akash V., Patel, Divyesh K.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-12-2023
Springer Nature B.V
Subjects:
Biological activity
Chemistry
Chemistry and Materials Science
Fungicides
Microorganisms
Organic Chemistry
Pyrimidines
Substitutes
Synthesis
benzothiazole-pyrimidine
antimicrobial
antimycobacterial
antioxidant
antimalarial
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Summary:In the present study a series of ethyl 4-(substituted)-2-methyl-4 H -benzo[4,5]thiazolo[3,2- a ]pyrimidine-3-carboxylate and ethyl 4-(substituted)-8-methoxy-2-methyl-4 H -benzo[4,5]thiazolo[3,2- a ]pyrimidine-3-carboxylate have been synthesized and evaluated for their preliminary antibacterial, antifungal, antimycobacterial, antioxidant and antimalarial activity. Among all the synthesized derivatives some of the compounds exists good biological activity which is similar to that of standard drugs. These facts make the compounds interesting candidates for further evaluation of their efficacy in the treatment microbial, tubercular and malarial disease.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428023130158