Search Results - "Mair, William"

AMPK at the Nexus of Energetics and Aging by Burkewitz, Kristopher, Zhang, Yue, Mair, William B.

“…When energy supply is low, organisms respond by slowing aging and increasing resistance to diverse age-related pathologies. Targeting the mechanisms…”
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You Are What You Host: Microbiome Modulation of the Aging Process by Heintz, Caroline, Mair, William

“…The critical impact that microbiota have on health and disease makes the interaction between host and microbiome increasingly important as we evaluate…”
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Aging and survival: the genetics of life span extension by dietary restriction by Mair, William, Dillin, Andrew

“…Reducing food intake to induce undernutrition but not malnutrition extends the life spans of multiple species, ranging from single-celled organisms to mammals…”
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Causal roles of mitochondrial dynamics in longevity and healthy aging by Sharma, Arpit, Smith, Hannah J, Yao, Pallas, Mair, William B

“…Mitochondria are organized in the cell in the form of a dynamic, interconnected network. Mitochondrial dynamics, regulated by mitochondrial fission, fusion,…”
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Fast fragmenting mitochondria by TORC2 by Valera-Alberni, Miriam, Mair, William B.

“…Mitochondria are dynamic organelles, changing their morphology and functional capacity in response to physiological and metabolic cues. A study uncovers a role…”
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Alternative splicing in aging and longevity by Bhadra, Malini, Howell, Porsha, Dutta, Sneha, Heintz, Caroline, Mair, William B.

“…Alternative pre-mRNA splicing increases the complexity of the proteome that can be generated from the available genomic coding sequences. Dysregulation of the…”
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Metabolic Communication and Healthy Aging: Where Should We Focus Our Energy? by Smith, Hannah J., Sharma, Arpit, Mair, William B.

“…Aging is associated with a loss of metabolic homeostasis and plasticity, which is causally linked to multiple age-onset pathologies. The majority of the…”
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Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness by Jacobi, David, Liu, Sihao, Burkewitz, Kristopher, Kory, Nora, Knudsen, Nelson H., Alexander, Ryan K., Unluturk, Ugur, Li, Xiaobo, Kong, Xiaohui, Hyde, Alexander L., Gangl, Matthew R., Mair, William B., Lee, Chih-Hao

“…Mitochondria undergo architectural/functional changes in response to metabolic inputs. How this process is regulated in physiological feeding/fasting states…”
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Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling by Weir, Heather J., Yao, Pallas, Huynh, Frank K., Escoubas, Caroline C., Goncalves, Renata L., Burkewitz, Kristopher, Laboy, Raymond, Hirschey, Matthew D., Mair, William B.

“…Mitochondrial network remodeling between fused and fragmented states facilitates mitophagy, interaction with other organelles, and metabolic flexibility. Aging…”
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Endogenous Hydrogen Sulfide Production Is Essential for Dietary Restriction Benefits by Hine, Christopher, Harputlugil, Eylul, Zhang, Yue, Ruckenstuhl, Christoph, Lee, Byung Cheon, Brace, Lear, Longchamp, Alban, Treviño-Villarreal, Jose H., Mejia, Pedro, Ozaki, C. Keith, Wang, Rui, Gladyshev, Vadim N., Madeo, Frank, Mair, William B., Mitchell, James R.

“…Dietary restriction (DR) without malnutrition encompasses numerous regimens with overlapping benefits including longevity and stress resistance, but unifying…”
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Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan by Han, Shuo, Schroeder, Elizabeth A., Silva-García, Carlos G., Hebestreit, Katja, Mair, William B., Brunet, Anne

“…Chromatin and metabolic states both influence lifespan, but how they interact in lifespan regulation is largely unknown. The COMPASS chromatin complex, which…”
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Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal by Burkewitz, Kristopher, Morantte, Ianessa, Weir, Heather J.M., Yeo, Robin, Zhang, Yue, Huynh, Frank K., Ilkayeva, Olga R., Hirschey, Matthew D., Grant, Ana R., Mair, William B.

“…Low energy states delay aging in multiple species, yet mechanisms coordinating energetics and longevity across tissues remain poorly defined. The conserved…”
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Predicting longevity responses to dietary restriction: A stepping stone toward precision geroscience by Perez-Matos, Maria C, Mair, William B

“…About the Authors: Maria C. Perez-Matos Affiliation: Department of Molecular Metabolism, Harvard T. H. Chan School of Public Health, Boston, Massachusetts,…”
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Splicing factor 1 modulates dietary restriction and TORC1 pathway longevity in C. elegans by Heintz, Caroline, Doktor, Thomas K., Lanjuin, Anne, Escoubas, Caroline C., Zhang, Yue, Weir, Heather J., Dutta, Sneha, Silva-García, Carlos Giovanni, Bruun, Gitte H., Morantte, Ianessa, Hoxhaj, Gerta, Manning, Brendan D., Andresen, Brage S., Mair, William B.

“…Precursor mRNA splicing homeostasis is a biomarker and predictor of life expectancy in Caenorhabditis elegans and defects in global pre-mRNA splicing…”
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Maintenance of appropriate size scaling of the C. elegans pharynx by YAP-1 by Stojanovski, Klement, Gheorghe, Ioana, Lenart, Peter, Lanjuin, Anne, Mair, William B., Towbin, Benjamin D.

“…Even slight imbalance between the growth rate of different organs can accumulate to a large deviation from their appropriate size during development. Here, we…”
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Atf-6 Regulates Lifespan through ER-Mitochondrial Calcium Homeostasis by Burkewitz, Kristopher, Feng, Gaomin, Dutta, Sneha, Kelley, Charlotte A., Steinbaugh, Michael, Cram, Erin J., Mair, William B.

“…Individually, dysfunction of both the endoplasmic reticulum (ER) and mitochondria has been linked to aging, but how communication between these organelles…”
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ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1 by Statzer, Cyril, Meng, Jin, Venz, Richard, Bland, Monet, Robida-Stubbs, Stacey, Patel, Krina, Petrovic, Dunja, Emsley, Raffaella, Liu, Pengpeng, Morantte, Ianessa, Haynes, Cole, Mair, William B., Longchamp, Alban, Filipovic, Milos R., Blackwell, T. Keith, Ewald, Collin Y.

“…Inhibition of the master growth regulator mTORC1 (mechanistic target of rapamycin complex 1) slows ageing across phyla, in part by reducing protein synthesis…”
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Feedback regulation via AMPK and HIF-1 mediates ROS-dependent longevity in Caenorhabditis elegans by Hwang, Ara B, Ryu, Eun-A, Artan, Murat, Chang, Hsin-Wen, Kabir, Mohammad Humayun, Nam, Hyun-Jun, Lee, Dongyeop, Yang, Jae-Seong, Kim, Sanguk, Mair, William B, Lee, Cheolju, Lee, Siu Sylvia, Lee, Seung-Jae

“…Significance Reactive oxygen species (ROS) have long been thought to cause aging and considered to be toxic byproducts generated during mitochondrial…”
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Chromatin-Bound Nuclear Pore Components Regulate Gene Expression in Higher Eukaryotes by Capelson, Maya, Liang, Yun, Schulte, Roberta, Mair, William, Wagner, Ulrich, Hetzer, Martin W.

“…Nuclear pore complexes have recently been shown to play roles in gene activation; however their potential involvement in metazoan transcription remains…”
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy by Egan, Daniel F, Shackelford, David B, Mihaylova, Maria M, Gelino, Sara, Kohnz, Rebecca A, Mair, William, Vasquez, Debbie S, Joshi, Aashish, Gwinn, Dana M, Taylor, Rebecca, Asara, John M, Fitzpatrick, James, Dillin, Andrew, Viollet, Benoit, Kundu, Mondira, Hansen, Malene, Shaw, Reuben J

“…Adenosine monophosphate-activated protein kinase (AMPK) is a conserved sensor of intracellular energy activated in response to low nutrient availability and…”
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