Search Results - "Maini, P. K"

Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer by GATENBY, R. A, SMALLBONE, K, MAINI, P. K, ROSE, F, AVERILL, J, NAGLE, R. B, WORRALL, L, GILLIES, R. J

“…Conceptual models of carcinogenesis typically consist of an evolutionary sequence of heritable changes in genes controlling proliferation, apoptosis, and…”
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Overview of Mathematical Approaches Used to Model Bacterial Chemotaxis II: Bacterial Populations by Tindall, M. J., Maini, P. K., Porter, S. L., Armitage, J. P.

“…We review the application of mathematical modeling to understanding the behavior of populations of chemotactic bacteria. The application of continuum…”
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Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study by Martin, N K, Robey, I F, Gaffney, E A, Gillies, R J, Gatenby, R A, Maini, P K

“…Background: Clinical positron emission tomography imaging has demonstrated the vast majority of human cancers exhibit significantly increased glucose…”
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An integrative computational model for intestinal tissue renewal by Van Leeuwen, I. M. M., Mirams, G. R., Walter, A., Fletcher, A., Murray, P., Osborne, J., Varma, S., Young, S. J., Cooper, J., Doyle, B., Pitt-Francis, J., Momtahan, L., Pathmanathan, P., Whiteley, J. P., Chapman, S. J., Gavaghan, D. J., Jensen, O. E., King, J. R., Maini, P. K., Waters, S. L., Byrne, H. M.

“…Objectives:  The luminal surface of the gut is lined with a monolayer of epithelial cells that acts as a nutrient absorptive engine and protective barrier. To…”
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A cellular automaton model for tumour growth in inhomogeneous environment by Alarcón, T., Byrne, H.M., Maini, P.K.

“…Most of the existing mathematical models for tumour growth and tumour-induced angiogenesis neglect blood flow. This is an important factor on which both…”
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Stripe Formation in Juvenile Pomacanthus Explained by a Generalized Turing Mechanism with Chemotaxis by Painter, K. J., Maini, P. K., Othmer, H. G.

“…Current interest in pattern formation can be traced to a seminal paper by Turing, who demonstrated that a system of reacting and diffusing chemicals, called…”
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A clock and wavefront mechanism for somite formation by Baker, R.E., Schnell, S., Maini, P.K.

“…Somitogenesis, the sequential formation of a periodic pattern along the antero-posterior axis of vertebrate embryos, is one of the most obvious examples of the…”
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Genome organization is a major component of gene expression control in response to stress and during the cell division cycle in trypanosomes by Kelly, S., Kramer, S., Schwede, A., Maini, P. K., Gull, K., Carrington, M.

“…The trypanosome genome is characterized by RNA polymerase II-driven polycistronic transcription of protein-coding genes. Ten to hundreds of genes are…”
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A mechanism for morphogen-controlled domain growth by Baker, R E, Maini, P K

“…Many developmental systems are organised via the action of graded distributions of morphogens. In the Drosophila wing disc, for example, recent experimental…”
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Travelling waves in a wound healing assay by Maini, P.K, McElwain, D.L.S, Leavesley, D

“…Several authors have predicted that cell propagation in a number of biological contexts, for example, wound healing, tumour cell invasion, angiogenesis etc.,…”
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A mathematical model of the effects of hypoxia on the cell-cycle of normal and cancer cells by Alarcón, T., Byrne, H.M., Maini, P.K.

“…The evolution of the cell-cycle is known to be influenced by environmental conditions, including lack of extracellular oxygen (hypoxia). Notably, hypoxia…”
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A theoretical framework for transitioning from patient-level to population-scale epidemiological dynamics: influenza A as a case study by Hart, W S, Maini, P K, Yates, C A, Thompson, R N

“…Multi-scale epidemic forecasting models have been used to inform population-scale predictions with within-host models and/or infection data collected in…”
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Modeling Longitudinal Preclinical Tumor Size Data to Identify Transient Dynamics in Tumor Response to Antiangiogenic Drugs by Hutchinson, LG, Mueller, H‐J, Gaffney, EA, Maini, PK, Wagg, J, Phipps, A, Boetsch, C, Byrne, HM, Ribba, B

“…Experimental evidence suggests that antiangiogenic therapy gives rise to a transient window of vessel normalization, within which the efficacy of radiotherapy…”
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Towards whole-organ modelling of tumour growth by Alarcón, T., Byrne, H.M., Maini, P.K.

“…Multiscale approaches to modelling biological phenomena are growing rapidly. We present here some recent results on the formulation of a theoretical framework…”
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Mode-doubling and tripling in reaction-diffusion patterns on growing domains: a piecewise linear model by Crampin, E J, Gaffney, E A, Maini, P K

“…Reaction-diffusion equations are ubiquitous as models of biological pattern formation. In a recent paper we have shown that incorporation of domain growth in a…”
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Oscillatory dynamics in a model of vascular tumour growth--implications for chemotherapy by Stamper, I J, Owen, M R, Maini, P K, Byrne, H M

“…Investigations of solid tumours suggest that vessel occlusion may occur when increased pressure from the tumour mass is exerted on the vessel walls. Since…”
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Editorial Special Section on Multiscale Cancer Modeling by Wang, Z., Maini, P. K.

“…The papers in this special section focus on the use of multiscale modeling in the field of cancer research. Cancer is a complex, heterogeneous disease,…”
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Enzyme Kinetics at High Enzyme Concentration by Schnell, S., Maini, P.K.

“…We re-visit previous analyses of the classical Michaelis–Menten substrate–enzyme reaction and, with the aid of the reverse quasi-steady-state assumption, we…”
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A morphoelastic model for dermal wound closure by Bowden, L. G., Byrne, H. M., Maini, P. K., Moulton, D. E.

“…We develop a model of wound healing in the framework of finite elasticity, focussing our attention on the processes of growth and contraction in the dermal…”
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Mesoscopic and continuum modelling of angiogenesis by Spill, F., Guerrero, P., Alarcon, T., Maini, P. K., Byrne, H. M.

“…Angiogenesis is the formation of new blood vessels from pre-existing ones in response to chemical signals secreted by, for example, a wound or a tumour. In…”
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