Search Results - "Maini, N."

Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics by Feldmann, Marc, Maini, Sir Ravinder N.

“…Advances in cDNA and monoclonal antibody technology in the 1980s fuelled the discovery and characterization of the properties of cytokines. It became apparent…”
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Perspectives From Masters in Rheumatology and Autoimmunity: Can We Get Closer to a Cure for Rheumatoid Arthritis? by Feldmann, Marc, Maini, Ravinder N.

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TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases by Feldmann, Marc, Maini, Ravinder N

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ANTI-TNFα THERAPY OF RHEUMATOID ARTHRITIS: What Have We Learned? by Feldmann, Marc, Maini, Ravinder N

“…Rheumatoid arthritis (RA), a systemic disease, is characterized by a chronic inflammatory reaction in the synovium of joints and is associated with…”
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Infliximab and Methotrexate in the Treatment of Rheumatoid Arthritis by Lipsky, Peter E, van der Heijde, Desiree M.F.M, St. Clair, E. William, Furst, Daniel E, Breedveld, Ferdinand C, Kalden, Joachim R, Smolen, Josef S, Weisman, Michael, Emery, Paul, Feldmann, Marc, Harriman, Gregory R, Maini, Ravinder N

“…Tumor necrosis factor α (TNF-α) has a central role in the pathogenesis of rheumatoid arthritis, 1 – 3 as demonstrated by the clinical benefit of…”
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ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS by Feldmann, Marc, Brennan, Fionula M, Maini, Ravinder N

“…Analysis of cytokine mRNA and protein in rheumatoid arthritis tissue revealed that many proinflammatory cytokines such as TNFα, IL-1, IL-6, GM-CSF, and…”
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Anti-Cytokine Therapy for Rheumatoid Arthritis by Maini, R. N, Taylor, P. C

“…Tumor necrosis factor (TNF ) and interleukin-1 (IL-1) are important in mediating inflammation in rheumatoid arthritis (RA). Randomized phase II and III…”
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Trials of anti-tumour necrosis factor therapy for COVID-19 are urgently needed by Feldmann, Marc, Maini, Ravinder N, Woody, James N, Holgate, Stephen T, Winter, Gregory, Rowland, Matthew, Richards, Duncan, Hussell, Tracy

“…[...]after anti-TNF infusion tissue TNF is reduced as it passes into the blood bound to the anti-TNF antibody. Experimental studies suggest that if the…”
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Mesenchymal precursor cells in the blood of normal individuals by Zvaifler, N J, Marinova-Mutafchieva, L, Adams, G, Edwards, C J, Moss, J, Burger, J A, Maini, R N

“…STATEMENT OF FINDINGS: Mesenchymal precursor cells found in the blood (BMPCs) of normal persons adhere to plastic and glass and proliferate logarithmically in…”
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Infliximab in active early rheumatoid arthritis by Breedveld, F C, Emery, P, Keystone, E, Patel, K, Furst, D E, Kalden, J R, St Clair, E W, Weisman, M, Smolen, J, Lipsky, P E, Maini, R N

“…Objective: To examine the impact of the combination of infliximab plus methotrexate (MTX) on the progression of structural damage in patients with early…”
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Transforming growth factor‐β1 in rheumatoid synovial membrane and cartilage pannus junction by CHU, C. Q., FIELD, M., ABNEY, E., ZHENG, R. Q. H., ALLARD, S., FELDMANN, M., MAINI, R. N.

“…SUMMARY Transforming growth factor (TGF)‐β has been shown to promote tissue repair and have immunosuppressivc actions, and has been proposed to have a role in…”
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Anti-Tumor Necrosis Factor Ameliorates Joint Disease in Murine Collagen- Induced Arthritis by Williams, Richard O., Feldmann, Marc, Maini, Ravinder N.

“…There is considerable evidence implicating tumor necrosis factor α (TNF-α) in the pathogenesis of rheumatoid arthritis. This evidence is based not only on the…”
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ATTIRE: Albumin To prevenT Infection in chronic liveR failurE: study protocol for a single-arm feasibility trial by China, Louise, Muirhead, Nicola, Skene, Simon S, Shabir, Zainib, PH De Maeyer, Roel, Maini, Alexander AN, W Gilroy, Derek, J O'Brien, Alastair

“…IntroductionCirculating prostaglandin E2 levels are elevated in acutely decompensated cirrhosis and have been shown to contribute to immune suppression…”
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Immunoregulatory role of interleukin 10 in rheumatoid arthritis by KATSIKIS, P. D, CONG-QIU CHU, BRENNAN, F. M, MAINI, R. N, FELDMANN, M

“…The presence and the role of interleukin 10 (IL-10), a potent cytokine synthesis inhibitory factor and antiinflammatory cytokine, were investigated in…”
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Randomised double-blind comparison of chimeric monoclonal antibody to tumour necrosis factor alpha (cA2) versus placebo in rheumatoid arthritis by Elliott, M J, Maini, R N, Feldmann, M, Kalden, J R, Antoni, C, Smolen, J S, Leeb, B, Breedveld, F C, Macfarlane, J D, Bijl, H

“…Tumour necrosis factor alpha (TNF alpha) is a critical inflammatory mediator in rheumatoid arthritis, and may therefore be a useful target for specific…”
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Anti-TNF therapy, from rationale to standard of care: what lessons has it taught us? by Feldmann, Marc, Maini, Ravinder N

“…In the mid-1980s, new molecular tools enabled the biology of cytokine expression and regulation to be studied. Our group uncovered a TNF-dependent cascade in…”
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The sweetie tube and a paediatric difficult airway by McGrattan, T, Shelley, B, Maini, N, Handley, T, Moores, A

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Association between baseline radiographic damage and improvement in physical function after treatment of patients with rheumatoid arthritis by Breedveld, F C, Han, C, Bala, M, van der Heijde, D, Baker, D, Kavanaugh, A F, Maini, R N, Lipsky, P E

“…Objectives: To identify factors associated with poor physical function in rheumatoid arthritis and to assess whether baseline joint damage has an impact on…”
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Regulation of cytokines, cytokine inhibitors, and acute-phase proteins following anti-TNF-alpha therapy in rheumatoid arthritis by Charles, P, Elliott, M J, Davis, D, Potter, A, Kalden, J R, Antoni, C, Breedveld, F C, Smolen, J S, Eberl, G, deWoody, K, Feldmann, M, Maini, R N

“…Treatment with a chimeric mAb to TNF-alpha has been shown to suppress inflammation and improve patient well-being in rheumatoid arthritis (RA), but the…”
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Repeated therapy with monoclonal antibody to tumour necrosis factor alpha (cA2) in patients with rheumatoid arthritis by Elliott, M J, Maini, R N, Feldmann, M, Long-Fox, A, Charles, P, Bijl, H, Woody, J N

“…Our in-vitro, animal, and early clinical data suggest that tumour necrosis factor alpha (TNF alpha) is an important target for specific biological therapy in…”
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