Search Results - "Main, Martin J."

RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor by Foord, Steven M, McLatchie, Linda M, Fraser, Neil J, Main, Martin J, Wise, Alan, Brown, Jason, Thompson, Nicola, Solari, Roberto, Lee, Melanie G

“…Calcitonin-gene-related peptide (CGRP) and adrenomedullin are related peptides with distinct pharmacological profiles. Here we show that a receptor with seven…”
Get full text

Advanced molecular imaging for the characterisation of complex medicines by Yilmaz, Duygu, Sharp, Paul S., Main, Martin J., Simpson, Peter B.

“…•Complex medicines with a novel delivery mechanism or chemistry are growing in clinical impact.•New chemistry and carrier technology will take complex…”
Get full text

Functional expression of the voltage-gated Na⁺-channel Nav1.7 is necessary for EGF-mediated invasion in human non-small cell lung cancer cells by Campbell, Thomas M, Main, Martin J, Fitzgerald, Elizabeth M

“…Various ion channels are expressed in human cancers where they are intimately involved in proliferation, angiogenesis, invasion and metastasis. Expression of…”
Get full text

Heterologous expression and functional analysis of rat Nav1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7-23 by John, Victoria H, Main, Martin J, Powell, Andrew J, Gladwell, Zoe M, Hick, Caroline, Sidhu, Harjeet S, Clare, Jeff J, Tate, Simon, Trezise, Derek J

“…The voltage-gated sodium channel NaV1.8 (SNS, PN3) is thought to be a molecular correlate of the dorsal root ganglion (DRG) tetrodotoxin resistant (TTX-R) Na+…”
Get full text

Positioning High-Throughput CETSA in Early Drug Discovery through Screening against B-Raf and PARP1 by Shaw, Joseph, Dale, Ian, Hemsley, Paul, Leach, Lindsey, Dekki, Nancy, Orme, Jonathan P, Talbot, Verity, Narvaez, Ana J, Bista, Michal, Martinez Molina, Daniel, Dabrowski, Michael, Main, Martin J, Gianni, Davide

“…Methods to measure cellular target engagement are increasingly being used in early drug discovery. The Cellular Thermal Shift Assay (CETSA) is one such method…”
Get more information

Use of escin as a perforating agent on the IonWorks quattro automated electrophysiology platform by Morton, Michael J, Main, Martin J

“…The automated electrophysiology platform IonWorks has facilitated the medium-throughput study of ion channel biology and pharmacology. Electrical and chemical…”
Get more information

Functional expression of the voltage-gated sodium channel, Nav1.7, underlies epidermal growth factor-mediated invasion in human [R1.S1] non-small cell lung cancer cells by Campbell, Thomas M., Main, Martin J., Fitzgerald, Elizabeth M.

“…Various ion channels are expressed in human cancers where they are intimately involved in proliferation, angiogenesis, invasion and metastasis. Expression of…”
Get full text

Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product by Christopoulos, G, Perry, K J, Morfis, M, Tilakaratne, N, Gao, Y, Fraser, N J, Main, M J, Foord, S M, Sexton, P M

“…Receptor activity-modifying proteins (RAMPs) are single-transmembrane proteins that transport the calcitonin receptor-like receptor (CRLR) to the cell surface…”
Get more information

Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine by Main, M J, Cryan, J E, Dupere, J R, Cox, B, Clare, J J, Burbidge, S A

“…Retigabine is a novel anticonvulsant with an unknown mechanism of action. It has recently been reported that retigabine modulates a potassium channel current…”
Get more information

The CGRP receptor can couple via pertussis toxin sensitive and insensitive G proteins by Main, Martin J, Brown, Jason, Brown, Susan, Fraser, Neil J, Foord, Steven M

“…Swiss 3T3 cell lines were constructed co-expressing receptor activity modifying protein (RAMP) 1 with the calcitonin receptor-like receptor (CRLR), and showed…”
Get full text

The amino terminus of receptor activity modifying proteins is a critical determinant of glycosylation state and ligand binding of calcitonin receptor-like receptor by Fraser, N J, Wise, A, Brown, J, McLatchie, L M, Main, M J, Foord, S M

“…The calcitonin receptor-like receptor (CRLR) can function as either a receptor for calcitonin gene-related peptide (CGRP) or for adrenomedullin (ADM),…”
Get more information

Heterodimerization is required for the formation of a functional GABAB receptor by WHITE, J. H, WISE, A, MAIN, M. J, GREEN, A, FRASER, N. J, DISNEY, G. H, BARNES, A. A, EMSON, P, FOORD, S. M, MARSHALL, F. H

“…GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic…”
Get full text

An industrial perspective on utilizing functional ion channel assays for high throughput screening by Worley, 3rd, Jennings F, Main, Martin J

“…The ability to apply large-scale screening formats to measures of ion channel function offers immense opportunities for drug discovery and academic research…”
Get more information

Heterodimerization is required for the formation of a functional GABA(B) receptor by White, J H, Wise, A, Main, M J, Green, A, Fraser, N J, Disney, G H, Barnes, A A, Emson, P, Foord, S M, Marshall, F H

“…GABA (gamma-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic…”
Get full text

Calcium sensing properties of the GABA(B) receptor by Wise, A, Green, A, Main, M J, Wilson, R, Fraser, N, Marshall, F H

“…The GABA(B) receptor has been shown to consist of a heterodimer of two related 7-transmembrane receptors GABAB-R1 and GABA(B)-R2. These receptors share close…”
Get full text

Heterologous expression and functional analysis of rat Na V1.8 (SNS) voltage-gated sodium channels in the dorsal root ganglion neuroblastoma cell line ND7–23 by John, Victoria H., Main, Martin J., Powell, Andrew J., Gladwell, Zoe M., Hick, Caroline, Sidhu, Harjeet S., Clare, Jeff J., Tate, Simon, Trezise, Derek J.

“…The voltage-gated sodium channel Na V1.8 (SNS, PN3) is thought to be a molecular correlate of the dorsal root ganglion (DRG) tetrodotoxin resistant (TTX-R) Na…”
Get full text

Calcium sensing properties of the GABA B receptor by Wise, Alan, Green, Andrew, Main, Martin J, Wilson, Richard, Fraser, Neil, Marshall, Fiona H

“…The GABA B receptor has been shown to consist of a heterodimer of two related 7-transmembrane receptors GABA B-R1 and GABA B-R2. These receptors share close…”
Get full text

Heterodimerization is required for the formation of a functional GABA B receptor by Marshall, Fiona H, White, Julia H, Wise, Alan, Main, Martin J, Green, Andrew, Fraser, Neil J, Disney, Graham H, Barnes, Ashley A, Emson, Piers, Foord, Steven M

“…GABA (γ-aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through ionotropic…”
Get full text

Differences in the effects of tachykinin NK1 receptor antagonists: neuronal versus smooth muscle tissues by Seabrook, G R, Main, M J, Razzaque, Z, Longmore, J

“…The effects of three tachykinin NK1 receptor antagonists (L-668,169, (+/-)-RP 67580, and (+/-)-CP 96.345) were examined for their ability to antagonise…”
Get more information

Heterodimerization is required for the formation of a functional GABA sub(B) receptor by White, J H, Wise, A, Main, MJ, Green, A, Fraser, N J, Disney, G H, Barnes, A A, Emson, P, Foord, S M, Marshall, F H

“…GABA ( gamma -aminobutyric acid) is the main inhibitory neurotransmitter in the mammalian central nervous system, where it exerts its effects through…”
Get full text