Search Results - "Main, Alan J"

Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders by Shi, Zhi-Cai, Devasagayaraj, Arokiasamy, Gu, Kunjian, Jin, Haihong, Marinelli, Brett, Samala, Lakshman, Scott, Sheldon, Stouch, Terry, Tunoori, Ashok, Wang, Ying, Zang, Yi, Zhang, Chengmin, Kimball, S. David, Main, Alan J, Sun, Weimei, Yang, Qi, Nouraldeen, Amr, Yu, Xiang-Qing, Buxton, Eric, Patel, Shiv, Nguyen, Nghi, Swaffield, Jon, Powell, David R, Wilson, Alan, Liu, Qingyun

“…The discovery of a novel class of peripheral tryptophan hydroxylase (TPH) inhibitors is described. This class of TPH inhibitors exhibits excellent potency in…”
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Mo2021 Lx1606 (Aka LX1032), a Peripheral Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model by Oravecz, Tamas, Jhaver, Kanchan, Yang, Qi M, Wilson, Alan G, Main, Alan J, Zambrowicz, Brian

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Tu1333 Lx1033, a Second Generation Locally-Acting Serotonin Synthesis Inhibitor Demonstrates Increased Potency and Favorable Safety Profile in Preclinical Studies by Yang, Qi M, Yu, Wangsheng, Swaffield, Jonathan, Powell, David, Wilson, Alan G, Brommage, Robert, Yalamanchili, Padmaja, Heydorn, William, Main, Alan J, Zambrowicz, Brian

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Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors by Jin, Haihong, Cianchetta, Giovanni, Devasagayaraj, Arokiasamy, Gu, Kunjian, Marinelli, Brett, Samala, Lakshman, Scott, Sheldon, Stouch, Terry, Tunoori, Ashok, Wang, Ying, Zang, Yi, Zhang, Chengmin, David Kimball, S., Main, Alan J., Ding, Zhi-Ming, Sun, Weimei, Yang, Qi, Yu, Xiang-Qing, Powell, David R., Wilson, Alan, Liu, Qingyun, Shi, Zhi-Cai

“…Novel, potent tryptophan hydroxylase inhibitors were identified. Their SAR and computer modeling studies were conducted. Tryptophan hydroxylase (TPH) is a key…”
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907 LX1031, a Novel Locally-Acting Inhibitor of Serotonin (5-HT) Synthesis Significantly Improves Symptoms in Patients With IBS by Brown, Philip, Riff, Dennis S, Jackson, Jessica, Frazier, Kenneth, Clark, Elaine, Yang, Qi M, Walke, Wade, Freiman, Joel, Main, Alan J, Zambrowicz, Brian, Sands, Arthur

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S1053 Serotonin Biomarker Levels Correlate With Clinical Response in Phase 2 Trial of LX1031, a Novel Serotonin Synthesis Inhibitor for Non-Constipating IBS by Zambrowicz, Brian, Brown, Philip, Jackson, Jessica, Frazier, Kenneth, Clark, Elaine, Yang, Qi M, Walke, Wade, Freiman, Joel, Powell, David, Main, Alan J, Sands, Arthur

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Synthesis and Structure-Activity Relationships of Oxamic Acid and Acetic Acid Derivatives Related to L-Thyronine by Yokoyama, Naokata, Walker, Gordon N, Main, Alan J, Stanton, James L, Morrissey, Michael M, Boehm, Charles, Engle, Allan, Neubert, Alan D, Wasvary, Jong M

“…Aryloxamic acids 7 and 23, (arylamino)acetic acids 29, arylpropionic acids 33, arylthioacetic acids 37, and (aryloxy)acetic acid 41 related to…”
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N-aryl cinnamides : A novel class of rigid and highly potent leukotriene B4 receptor antagonists by GREENSPAN, P. D, MAIN, A. J, JACKSON, R. H, UZIEL-FUSI, S, BHAGWAT, S. S, BARSKY, L. I, DOTI, R. A, ENGLE, A. R, FREY, L. M, ZHOU, H, LIPSON, K. E, CHIN, M. H

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Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 2. Synthesis and biological activity of 8-(benzenesulfonamido)-7-(3-pyridinyl)octanoic acid and related compounds by Main, Alan J, Goldstein, Robert, Cohen, David, Furness, Patricia, Lee, Warren

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Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 3. Pyridinylalkyl-substituted 8-[(arylsulfonyl)amino]octanoic acids by Main, Alan J, Bhagwat, Shripad S, Boswell, Clay, Goldstein, Robert, Gude, Candido, Cohen, David, Furness, Patricia, Lee, Warren, Louzan, Marissa

“…A series of 8-[(arylsulfonyl)amino]octanoic acids substituted with a pyridinylalkyl group along the chain were synthesized and tested in vitro for their…”
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Genetic and Chemical Inhibition of Sphingosine 1-Phosphate Lyase Results in Peripheral Lymphopenia and Alleviates Disease Development in Animal Models of Inflammation and Autoimmunity by Oravecz, Tamas, Donoviel, Michael S., Anderson, Stephen J., Carson, Kenneth, Sun, Weimei, Swaffield, Jonathan, Liu, Qingyun, Kimball, S. David, Piggott, James R., Main, Alan J., Zambrowicz, Brian P., Sands, Arthur T., Turner, C. Alexander, Augeri, David J.

“…The ceramide metabolite sphingosine 1-phosphate (S1P) is an important modulator of a wide variety of physiologic functions via its action as a second messenger…”
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N-aryl cinnamides: A novel class of rigid and highly potent leukotriene B 4 receptor antagonists by Greenspan, Paul D., Main, Alan J., Bhagwat, Shripad S., Barsky, Lester I., Doti, Robert A., Engle, Alan R., Frey, Lisa M., Zhou, Huanghai, Lipson, Kenneth E., Chin, Michael H., Jackson, Robert H., Uziel-Fusi, Susan

“…A series of N-aryl cinnamides has been prepared and assayed for antagonism of the leukotriene B 4 receptor. Several compounds in this series were found to be…”
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