Search Results - "Maier, Johannes K. X"

Assessment of fully automated antibody homology modeling protocols in molecular operating environment by Maier, Johannes K. X., Labute, Paul

“…ABSTRACT The success of antibody‐based drugs has led to an increased demand for predictive computational tools to assist antibody engineering efforts…”
Get full text

AggScore: Prediction of aggregation‐prone regions in proteins based on the distribution of surface patches by Sankar, Kannan, Krystek, Stanley R., Carl, Stephen M., Day, Tyler, Maier, Johannes K. X.

“…Protein aggregation is a phenomenon that has attracted considerable attention within the pharmaceutical industry from both a developability standpoint (to…”
Get full text

The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7 by Maier, Johannes K. X, Lahoua, Zahia, Gendron, Nathalie H, Fetni, Raouf, Johnston, Anne, Davoodi, Jamshid, Rasper, Dita, Roy, Sophie, Slack, Ruth S, Nicholson, Donald W, MacKenzie, Alex E

“…The neuronal apoptosis inhibitory protein (NAIP) was identified as a candidate gene for the inherited neurodegenerative disorder spinal muscular atrophy. NAIP…”
Get full text

A Descriptor Set for Quantitative Structure‐property Relationship Prediction in Biologics by Sankar, Kannan, Trainor, Kyle, Blazer, Levi L., Adams, Jarrett J., Sidhu, Sachdev S., Day, Tyler, Meiering, Elizabeth, Maier, Johannes K. X.

“…There has been a remarkable increase in the number of biologics, especially monoclonal antibodies, in the market over the last decade. In addition to attaining…”
Get full text

Distribution of Neuronal Apoptosis Inhibitory Protein in Human Tissues by Maier, Johannes K.X, Balabanian, Sylvia, Coffill, Cynthia R, Stewart, Alexandra, Pelletier, Louise, Franks, Douglas J, Gendron, Nathalie H, MacKenzie, Alex E

“…The neuronal apoptosis inhibitory protein (NAIP) gene, also known as the baculovirus inhibitor of apoptosis repeat-containing protein 1 (BIRC1) gene, is a…”
Get full text

Accurate Prediction of Protein Thermodynamic Stability Changes upon Residue Mutation using Free Energy Perturbation by Scarabelli, Guido, Oloo, Eliud O., Maier, Johannes K.X., Rodriguez-Granillo, Agustina

“…[Display omitted] •Compared performance of MM/GBSA and FEP+ in predicting stability of protein variants.•Validated on a dataset of 328 experimentally…”
Get full text