Search Results - "Maier, Helena J"

A unifying structural and functional model of the coronavirus replication organelle: Tracking down RNA synthesis by Snijder, Eric J, Limpens, Ronald W A L, de Wilde, Adriaan H, de Jong, Anja W M, Zevenhoven-Dobbe, Jessika C, Maier, Helena J, Faas, Frank F G A, Koster, Abraham J, Bárcena, Montserrat

“…Zoonotic coronavirus (CoV) infections, such as those responsible for the current severe acute respiratory syndrome-CoV 2 (SARS-CoV-2) pandemic, cause grave…”
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The S2 Subunit of Infectious Bronchitis Virus Beaudette Is a Determinant of Cellular Tropism by Bickerton, Erica, Maier, Helena J, Stevenson-Leggett, Phoebe, Armesto, Maria, Britton, Paul

“…The spike (S) glycoprotein of the avian gammacoronavirus infectious bronchitis virus (IBV) is comprised of two subunits (S1 and S2), has a role in virulence ,…”
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The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins by Conceicao, Carina, Thakur, Nazia, Human, Stacey, Kelly, James T, Logan, Leanne, Bialy, Dagmara, Bhat, Sushant, Stevenson-Leggett, Phoebe, Zagrajek, Adrian K, Hollinghurst, Philippa, Varga, Michal, Tsirigoti, Christina, Tully, Matthew, Chiu, Chris, Moffat, Katy, Silesian, Adrian Paul, Hammond, John A, Maier, Helena J, Bickerton, Erica, Shelton, Holly, Dietrich, Isabelle, Graham, Stephen C, Bailey, Dalan

“…SARS Coronavirus 2 (SARS-CoV-2) emerged in late 2019, leading to the Coronavirus Disease 2019 (COVID-19) pandemic that continues to cause significant global…”
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Coronavirus RNA Synthesis Takes Place within Membrane-Bound Sites by Doyle, Nicole, Simpson, Jennifer, Hawes, Philippa C, Maier, Helena J

“…Infectious bronchitis virus (IBV), a gammacoronavirus, is an economically important virus to the poultry industry, as well as a significant welfare issue for…”
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Infectious bronchitis virus generates spherules from zippered endoplasmic reticulum membranes by Maier, Helena J, Hawes, Philippa C, Cottam, Eleanor M, Mantell, Judith, Verkade, Paul, Monaghan, Paul, Wileman, Tom, Britton, Paul

“…Replication of positive-sense RNA viruses is associated with the rearrangement of cellular membranes. Previous work on the infection of tissue culture cell…”
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The Porcine Deltacoronavirus Replication Organelle Comprises Double-Membrane Vesicles and Zippered Endoplasmic Reticulum with Double-Membrane Spherules by Doyle, Nicole, Hawes, Philippa C, Simpson, Jennifer, Adams, Lorin H, Maier, Helena J

“…Porcine deltacoronavirus (PDCoV) was first identified in Hong Kong in 2012 from samples taken from pigs in 2009. PDCoV was subsequently identified in the USA…”
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Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling by Brownsword, Matthew J, Doyle, Nicole, Brocard, Michèle, Locker, Nicolas, Maier, Helena J

“…Viruses must hijack cellular translation machinery to express viral genes. In many cases, this is impeded by cellular stress responses. These stress responses…”
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Involvement of autophagy in coronavirus replication by Maier, Helena J, Britton, Paul

“…Coronaviruses are single stranded, positive sense RNA viruses, which induce the rearrangement of cellular membranes upon infection of a host cell. This…”
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A Versatile Panel of Reference Gene Assays for the Measurement of Chicken mRNA by Quantitative PCR by Staines, Karen, Batra, Ambalika, Mwangi, William, Maier, Helena J, Van Borm, Steven, Young, John R, Fife, Mark, Butter, Colin

“…Quantitative real-time PCR assays are widely used for the quantification of mRNA within avian experimental samples. Multiple stably-expressed reference genes,…”
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The Genetic Stability, Replication Kinetics and Cytopathogenicity of Recombinant Avian Coronaviruses with a T16A or an A26F Mutation within the E Protein Is Cell-Type Dependent by Webb, Isobel, Keep, Sarah, Littolff, Kieran, Stuart, Jamie, Freimanis, Graham, Britton, Paul, Davidson, Andrew D, Maier, Helena J, Bickerton, Erica

“…The envelope (E) protein of the avian coronavirus infectious bronchitis virus (IBV) is a small-membrane protein present in two forms during infection: a…”
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Temperature Sensitivity: A Potential Method for the Generation of Vaccines against the Avian Coronavirus Infectious Bronchitis Virus by Keep, Sarah, Stevenson-Leggett, Phoebe, Steyn, Angela, Oade, Michael S, Webb, Isobel, Stuart, Jamie, Vervelde, Lonneke, Britton, Paul, Maier, Helena J, Bickerton, Erica

“…The infectious bronchitis virus (IBV) is a highly contagious economically important respiratory pathogen of domestic fowl. Reverse genetics allows for the…”
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Infectious Bronchitis Virus Nonstructural Protein 4 Alone Induces Membrane Pairing by Doyle, Nicole, Neuman, Benjamin W, Simpson, Jennifer, Hawes, Philippa C, Mantell, Judith, Verkade, Paul, Alrashedi, Hasan, Maier, Helena J

“…Positive-strand RNA viruses, such as coronaviruses, induce cellular membrane rearrangements during replication to form replication organelles allowing for…”
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Visualizing the autophagy pathway in avian cells and its application to studying infectious bronchitis virus by Maier, Helena J., Cottam, Eleanor M., Stevenson-Leggett, Phoebe, Wilkinson, Jessica A., Harte, Christopher J., Wileman, Tom, Britton, Paul

“…Autophagy is a highly conserved cellular response to starvation that leads to the degradation of organelles and long-lived proteins in lysosomes and is…”
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Coronavirus nsp6 proteins generate autophagosomes from the endoplasmic reticulum via an omegasome intermediate by Cottam, Eleanor M., Maier, Helena J., Manifava, Maria, Vaux, Laura C., Chandra-Schoenfelder, Priya, Gerner, Wilhelm, Britton, Paul, Ktistakis, Nicholas T., Wileman, Tom

“…Autophagy is a cellular response to starvation which generates autophagosomes to carry cellular organelles and long-lived proteins to lysosomes for…”
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Differential role of the influenza A virus polymerase PA subunit for vRNA and cRNA promoter binding by Maier, Helena J, Kashiwagi, Takahito, Hara, Koyu, Brownlee, George G

“…Abstract The RNA polymerase of influenza A virus is a heterotrimeric complex of PB1, PB2 and PA subunits that is required for transcription and replication of…”
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Quantification of Coronaviruses by Titration In Vitro and Ex Vivo by Dowgier, Giulia, Maier, Helena J

“…Several techniques are currently available to quickly and accurately quantify the number of virus particles in a sample, taking advantage of advanced…”
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Targeting the Conserved Stem Loop 2 Motif in the SARS-CoV-2 Genome by Lulla, Valeria, Wandel, Michal P, Bandyra, Katarzyna J, Ulferts, Rachel, Wu, Mary, Dendooven, Tom, Yang, Xiaofei, Doyle, Nicole, Oerum, Stephanie, Beale, Rupert, O'Rourke, Sara M, Randow, Felix, Maier, Helena J, Scott, William, Ding, Yiliang, Firth, Andrew E, Bloznelyte, Kotryna, Luisi, Ben F

“…RNA structural elements occur in numerous single-stranded positive-sense RNA viruses. The stem-loop 2 motif (s2m) is one such element with an unusually high…”
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Infectious Bronchitis Coronavirus Limits Interferon Production by Inducing a Host Shutoff That Requires Accessory Protein 5b by Kint, Joeri, Langereis, Martijn A, Maier, Helena J, Britton, Paul, van Kuppeveld, Frank J, Koumans, Joseph, Wiegertjes, Geert F, Forlenza, Maria

“…During infection of their host cells, viruses often inhibit the production of host proteins, a process that is referred to as host shutoff. By doing this,…”
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Activation of the chicken type I interferon response by infectious bronchitis coronavirus by Kint, Joeri, Fernandez-Gutierrez, Marcela, Maier, Helena J, Britton, Paul, Langereis, Martijn A, Koumans, Joseph, Wiegertjes, Geert F, Forlenza, Maria

“…Coronaviruses from both the Alphacoronavirus and Betacoronavirus genera interfere with the type I interferon (IFN) response in various ways, ensuring the…”
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Ribopuromycylation in Coronavirus-Infected Cells by Brownsword, Matthew J, Maier, Helena J, Locker, Nicolas

“…Ribopuromycylation enables the visualization and quantitation of translation on a cellular level by immunofluorescence or in total using standard western…”
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