Search Results - "Maier, Curtis"

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    Nonclinical safety assessment of engineered T cell therapies by Lebrec, Herve, Maier, Curtis C., Maki, Kazushige, Ponce, Rafael, Shenton, Jacintha, Green, Shon

    Published in Regulatory toxicology and pharmacology (01-12-2021)
    “…Over the last decade, immunotherapy has established itself as an important novel approach in the treatment of cancer, resulting in a growing importance in…”
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    Challenges and gaps in immunosafety evaluation of therapeutics: An IQ DruSafe survey by Collinge, Mark, Neff-LaFord, Haley, Akella, Surekha, Fogal, Birgit, Fraser, Kathryn, Jabbour, Jacob, Harper, Kirsty, Maier, Curtis C., Malherbe, Laurent, Marshall, Nikki, Rao, Gautham K., Raman, Kavita, Skaggs, Hollie, Weber, Felix, Fuller, Claudette L.

    Published in Regulatory toxicology and pharmacology (01-06-2024)
    “…Immunotoxicology/immunosafety science is rapidly evolving, with novel modalities and immuno-oncology among the primary drivers of new tools and technologies…”
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    Modulation of Kv channel expression and function by TCR and costimulatory signals during peripheral CD4(+) lymphocyte differentiation by Liu, Qing-Hua, Fleischmann, Bernd K, Hondowicz, Brian, Maier, Curtis C, Turka, Laurence A, Yui, Katsuyuki, Kotlikoff, Michael I, Wells, Andrew D, Freedman, Bruce D

    Published in The Journal of experimental medicine (07-10-2002)
    “…Ionic signaling pathways, including voltage-dependent potassium (Kv) channels, are instrumental in antigen-mediated responses of peripheral T cells. However,…”
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    Immunomodulatory Effects of Anti-CD4 Antibody in Host Resistance against Infections and Tumors in Human CD4 Transgenic Mice by HERZYK, Danuta J, GORE, Elizabeth R, POLSKY, Rodd, NADWODNY, Kimberly L, MAIER, Curtis C, LIU, Susan, HART, Timothy K, HARMSEN, Allen G, BUGELSKI, Peter J

    Published in Infection and Immunity (01-02-2001)
    “…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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    Proteomic stabilization of Cynomolgus Macaque blood with PROT-1 for flow cytometric analysis of activated innate and adaptive immune cells after extended storage by Williams, Jamie, Genell, Caroline A, Nuti, Sandra, Delamere, Patricia A, Maier, Curtis C, Marshall, Nikki B

    Published in The Journal of immunology (1950) (01-05-2021)
    “…Abstract Flow cytometry is a widely used, and rapidly evolving, immunophenotyping application; however, limited advancements around sample stability and…”
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    Molecular mimicry of carcinoembryonic antigen by peptides derived from the structure of an anti-idiotype antibody by CHATTERJEE, S. K, TRIPATHI, P. K, CHAKRABORTY, M, YANNELLI, J, HAITO WANG, FOON, K. A, MAIER, C. C, BLALOCK, J. E, BHATTACHARYA-CHATTERJEE, M

    Published in Cancer research (Chicago, Ill.) (15-03-1998)
    “…Our goal was to use carcinoembryonic antigen (CEA) as a target for immunotherapy in CEA-positive cancer patients who are all immune tolerant to the native…”
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    The Use Of A Novel Stereological Sampling Approach To Estimate Islet, Duct And Acinar Total Cell Number And Compartment Volume In Nonhuman Primate Pancreas by Mirabile, Rosanna, Kambara, Takahito, Maier, Curtis, Gundersen, Hans Jorgen

    Published in The FASEB journal (01-04-2016)
    “…Abstract only Design‐based stereology is used to obtain quantitative estimates of biological structures from sections with known precision and unlike…”
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    Unique Molecular Surface Features of in vivo Tolerized T Cells by Maier, Curtis C., Bhandoola, Avinash, Borden, William, Yui, Katsuyuki, Hayakawa, Kyoko, Greene, Mark I.

    “…Differential expression of surface markers can frequently be used to distinguish functional subsets of T cells, yet a surface phenotype unique to T cells…”
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    IMMUNOPHARMACOLOGY OF RECOMBINANT HUMAN INTERLEUKIN-18 IN NON-HUMAN PRIMATES by Herzyk, Danuta J., Soos, Jeanne M., Maier, Curtis C., Gore, Elizabeth R., Narayanan, Padma K., Nadwodny, Kimberly L., Liu, Susan, Jonak, Zdenka L., Bugelski, Peter J.

    Published in Cytokine (Philadelphia, Pa.) (07-10-2002)
    “…Recombinant human interleukin (IL)-18 (rHuIL-18) has a potential as a therapeutic agent in cancer and is currently in drug development. Since human IL-18…”
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    Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification by Larkin, J, Lohr, T.A, Elefante, L, Shearin, J, Matico, R, Su, J.-L, Xue, Y, Liu, F, Genell, C, Miller, R.E, Tran, P.B, Malfait, A.-M, Maier, C.C, Matheny, C.J

    Published in Osteoarthritis and cartilage (01-08-2015)
    “…Summary Objective/Method Aggrecanase activity, most notably ADAMTS-5, is implicated in pathogenic cartilage degradation. Selective monoclonal antibodies (mAbs)…”
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    Synthetic CD4 exocyclic peptides antagonize CD4 holoreceptor binding and T cell activation by Zhang, Xin, Piatier-Tonneau, Dominique, Auffray, Charles, Murali, Ramachandran, Mahapatra, Ajit, Zhang, Fuqing, Maier, Curtis C, Saragovi, H, Greene, Mark I

    Published in Nature biotechnology (01-04-1996)
    “…We have developed peptide analogs to analyze precise human CD4 substructures involved in MHC class II binding. Forms of the complementarity determining-like…”
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    Challenges and opportunities for the future of monoclonal antibody development: Improving safety assessment and reducing animal use by Sewell, Fiona, Chapman, Kathryn, Couch, Jessica, Dempster, Maggie, Heidel, Shawn, Loberg, Lise, Maier, Curtis, Maclachlan, Timothy K, Todd, Marque, van der Laan, Jan Willem

    Published in mAbs (04-07-2017)
    “…The market for biotherapeutic monoclonal antibodies (mAbs) is large and is growing rapidly. However, attrition poses a significant challenge for the…”
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