Search Results - "Maier, Barbara"

A progressive T cell exhaustion program mapped across tissues in patients with lung cancer on immune checkpoint blockade by Mangana, Carolina, Maier, Barbara B.

“…Immune checkpoint blockade has reached the standard of care for patients with lung cancer. However, its mode of action in patients is still incompletely…”
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Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification by Leader, Andrew M., Grout, John A., Maier, Barbara B., Nabet, Barzin Y., Park, Matthew D., Tabachnikova, Alexandra, Chang, Christie, Walker, Laura, Lansky, Alona, Le Berichel, Jessica, Troncoso, Leanna, Malissen, Nausicaa, Davila, Melanie, Martin, Jerome C., Magri, Giuliana, Tuballes, Kevin, Zhao, Zhen, Petralia, Francesca, Samstein, Robert, D’Amore, Natalie Roy, Thurston, Gavin, Kamphorst, Alice O., Wolf, Andrea, Flores, Raja, Wang, Pei, Müller, Sören, Mellman, Ira, Beasley, Mary Beth, Salmon, Hélène, Rahman, Adeeb H., Marron, Thomas U., Kenigsberg, Ephraim, Merad, Miriam

“…Immunotherapy is a mainstay of non-small cell lung cancer (NSCLC) management. While tumor mutational burden (TMB) correlates with response to immunotherapy,…”
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Dietary Intake Regulates the Circulating Inflammatory Monocyte Pool by Jordan, Stefan, Tung, Navpreet, Casanova-Acebes, Maria, Chang, Christie, Cantoni, Claudia, Zhang, Dachuan, Wirtz, Theresa H., Naik, Shruti, Rose, Samuel A., Brocker, Chad N., Gainullina, Anastasiia, Hornburg, Daniel, Horng, Sam, Maier, Barbara B., Cravedi, Paolo, LeRoith, Derek, Gonzalez, Frank J., Meissner, Felix, Ochando, Jordi, Rahman, Adeeb, Chipuk, Jerry E., Artyomov, Maxim N., Frenette, Paul S., Piccio, Laura, Berres, Marie-Luise, Gallagher, Emily J., Merad, Miriam

“…Caloric restriction is known to improve inflammatory and autoimmune diseases. However, the mechanisms by which reduced caloric intake modulates inflammation…”
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Spatial immunophenotyping of FFPE tissues by imaging mass cytometry by Mangana, Carolina, Maier, Barbara B.

“…The immune compartment of a tissue is dynamic, changing to respond to infections, tumors, or therapeutic interventions. Within tissues, local microenvironments…”
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ImmGen report: sexual dimorphism in the immune system transcriptome by Gal-Oz, Shani Talia, Maier, Barbara, Yoshida, Hideyuki, Seddu, Kumba, Elbaz, Nitzan, Czysz, Charles, Zuk, Or, Stranger, Barbara E., Ner-Gaon, Hadas, Shay, Tal

“…Sexual dimorphism in the mammalian immune system is manifested as more frequent and severe infectious diseases in males and, on the other hand, higher rates of…”
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The interaction of CD4 + helper T cells with dendritic cells shapes the tumor microenvironment and immune checkpoint blockade response by Cohen, Merav, Giladi, Amir, Barboy, Oren, Hamon, Pauline, Li, Baoguo, Zada, Mor, Gurevich-Shapiro, Anna, Beccaria, Cristian Gabriel, David, Eyal, Maier, Barbara B, Buckup, Mark, Kamer, Iris, Deczkowska, Aleksandra, Le Berichel, Jessica, Bar, Jair, Iannacone, Matteo, Tanay, Amos, Merad, Miriam, Amit, Ido

“…Despite their key regulatory role and therapeutic potency, the molecular signatures of interactions between T cells and antigen-presenting myeloid cells within…”
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The cis-Regulatory Atlas of the Mouse Immune System by Yoshida, Hideyuki, Lareau, Caleb A., Ramirez, Ricardo N., Rose, Samuel A., Maier, Barbara, Wroblewska, Aleksandra, Desland, Fiona, Chudnovskiy, Aleksey, Mortha, Arthur, Dominguez, Claudia, Tellier, Julie, Kim, Edy, Dwyer, Dan, Shinton, Susan, Nabekura, Tsukasa, Qi, YiLin, Yu, Bingfei, Robinette, Michelle, Kim, Ki-Wook, Wagers, Amy, Rhoads, Andrew, Nutt, Stephen L., Brown, Brian D., Mostafavi, Sara, Buenrostro, Jason D., Benoist, Christophe

“…A complete chart of cis-regulatory elements and their dynamic activity is necessary to understand the transcriptional basis of differentiation and function of…”
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An IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis by LaMarche, Nelson M., Hegde, Samarth, Park, Matthew D., Maier, Barbara B., Troncoso, Leanna, Le Berichel, Jessica, Hamon, Pauline, Belabed, Meriem, Mattiuz, Raphaël, Hennequin, Clotilde, Chin, Theodore, Reid, Amanda M., Reyes-Torres, Iván, Nemeth, Erika, Zhang, Ruiyuan, Olson, Oakley C., Doroshow, Deborah B., Rohs, Nicholas C., Gomez, Jorge E., Veluswamy, Rajwanth, Hall, Nicole, Venturini, Nicholas, Ginhoux, Florent, Liu, Zhaoyuan, Buckup, Mark, Figueiredo, Igor, Roudko, Vladimir, Miyake, Kensuke, Karasuyama, Hajime, Gonzalez-Kozlova, Edgar, Gnjatic, Sacha, Passegué, Emmanuelle, Kim-Schulze, Seunghee, Brown, Brian D., Hirsch, Fred R., Kim, Brian S., Marron, Thomas U., Merad, Miriam

“…Myeloid cells are known to suppress antitumour immunity 1 . However, the molecular drivers of immunosuppressive myeloid cell states are not well defined. Here…”
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Next-Generation Sequencing of the Human Aqueous Humour Microbiome by Schlunck, Günther, Maier, Philip, Maier, Barbara, Maier, Wolfgang, Strempel, Sebastian, Reinhard, Thomas, Heinzelmann, Sonja

“…The microbiome of the ocular surface has been characterised, but only limited information is available on a possible silent intraocular microbial colonisation…”
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Role of renal function in risk assessment of target non-attainment after standard dosing of meropenem in critically ill patients: a prospective observational study by Ehmann, Lisa, Zoller, Michael, Minichmayr, Iris K, Scharf, Christina, Maier, Barbara, Schmitt, Maximilian V, Hartung, Niklas, Huisinga, Wilhelm, Vogeser, Michael, Frey, Lorenz, Zander, Johannes, Kloft, Charlotte

“…Severe bacterial infections remain a major challenge in intensive care units because of their high prevalence and mortality. Adequate antibiotic exposure has…”
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Variability of linezolid concentrations after standard dosing in critically ill patients: a prospective observational study by Zoller, Michael, Maier, Barbara, Hornuss, Cyrill, Neugebauer, Christina, Döbbeler, Gundula, Nagel, Dorothea, Holdt, Lesca Miriam, Bruegel, Mathias, Weig, Thomas, Grabein, Béatrice, Frey, Lorenz, Teupser, Daniel, Vogeser, Michael, Zander, Johannes

“…Severe infections in intensive care patients show high morbidity and mortality rates. Linezolid is an antimicrobial drug frequently used in critically ill…”
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Squalene emulsion-based vaccine adjuvants stimulate CD8 T cell, but not antibody responses, through a RIPK3-dependent pathway by Kim, Eui Ho, Woodruff, Matthew C, Grigoryan, Lilit, Maier, Barbara, Lee, Song Hee, Mandal, Pratyusha, Cortese, Mario, Natrajan, Muktha S, Ravindran, Rajesh, Ma, Huailiang, Merad, Miriam, Gitlin, Alexander D, Mocarski, Edward S, Jacob, Joshy, Pulendran, Bali

“…The squalene-based oil-in-water emulsion (SE) vaccine adjuvant MF59 has been administered to more than 100 million people in more than 30 countries, in both…”
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Predictors of Inadequate Linezolid Concentrations after Standard Dosing in Critically Ill Patients by Taubert, Max, Zoller, Michael, Maier, Barbara, Frechen, Sebastian, Scharf, Christina, Holdt, Lesca-Miriam, Frey, Lorenz, Vogeser, Michael, Fuhr, Uwe, Zander, Johannes

“…Adequate linezolid blood concentrations have been shown to be associated with an improved clinical outcome. Our goal was to assess new predictors of inadequate…”
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Type I interferon promotes alveolar epithelial type II cell survival during pulmonary Streptococcus pneumoniae infection and sterile lung injury in mice by Maier, Barbara B., Hladik, Anastasiya, Lakovits, Karin, Korosec, Ana, Martins, Rui, Kral, Julia B., Mesteri, Ildiko, Strobl, Birgit, Müller, Mathias, Kalinke, Ulrich, Merad, Miriam, Knapp, Sylvia

“…Protecting the integrity of the lung epithelial barrier is essential to ensure respiration and proper oxygenation in patients suffering from various types of…”
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Role of DNA sequence in chromatin remodeling and the formation of nucleosome-free regions by Lorch, Yahli, Maier-Davis, Barbara, Kornberg, Roger D

“…AT-rich DNA is concentrated in the nucleosome-free regions (NFRs) associated with transcription start sites of most genes. We tested the hypothesis that…”
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Quantification of linezolid in serum by LC-MS/MS using semi-automated sample preparation and isotope dilution internal standardization by Zander, Johannes, Maier, Barbara, Zoller, Michael, Teupser, Daniel, Vogeser, Michael

“…Linezolid serum concentrations have been shown to be highly variable in critically ill patients with often sub-therapeutic drug levels regarding minimal…”
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Markers of intestinal permeability are already altered in early stages of non-alcoholic fatty liver disease: Studies in children by Nier, Anika, Engstler, Anna Janina, Maier, Ina Barbara, Bergheim, Ina

“…Recent studies have shown that patients with manifest non-alcoholic fatty liver disease (NAFLD), e.g. steatosis grade 3 or steatohepatitis with or without…”
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Extraction of viral nucleic acids: Comparison of five automated nucleic acid extraction platforms by Verheyen, Jens, Kaiser, Rolf, Bozic, Michael, Timmen-Wego, Monika, Maier, Barbara K, Kessler, Harald H

“…Abstract Background Nucleic acid extraction has a major impact on the reliability of results in routine molecular diagnostics. Optimal isolation of nucleic…”
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A neutrophil-B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4 by Gawish, Riem, Maier, Barbara, Obermayer, Georg, Watzenboeck, Martin L, Gorki, Anna-Dorothea, Quattrone, Federica, Farhat, Asma, Lakovits, Karin, Hladik, Anastasiya, Korosec, Ana, Alimohammadi, Arman, Mesteri, Ildiko, Oberndorfer, Felicitas, Oakley, Fiona, Brain, John, Boon, Louis, Lang, Irene, Binder, Christoph J, Knapp, Sylvia

“…Sepsis is a life-threatening condition characterized by uncontrolled systemic inflammation and coagulation, leading to multiorgan failure. Therapeutic options…”
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Prevalence of Physiologic Sexual Dysfunction Is High Following Treatment for Rectal Cancer: But Is It the Only Thing That Matters? by Leon-Carlyle, Marisa, Schmocker, Selina, Victor, J Charles, Maier, Barbara-Anne, O’Connor, Brenda I, Baxter, Nancy N, McLeod, Robin S, Kennedy, Erin D

“…BACKGROUND:Although several studies have reported high rates of sexual dysfunction in patients treated for rectal cancer, most studies have been limited by…”
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