Search Results - "Maiello, Pauline"

Prevention of tuberculosis in macaques after intravenous BCG immunization by Darrah, Patricia A., Zeppa, Joseph J., Maiello, Pauline, Hackney, Joshua A., Wadsworth, Marc H., Hughes, Travis K., Pokkali, Supriya, Swanson, Phillip A., Grant, Nicole L., Rodgers, Mark A., Kamath, Megha, Causgrove, Chelsea M., Laddy, Dominick J., Bonavia, Aurelio, Casimiro, Danilo, Lin, Philana Ling, Klein, Edwin, White, Alexander G., Scanga, Charles A., Shalek, Alex K., Roederer, Mario, Flynn, JoAnne L., Seder, Robert A.

“…Mycobacterium tuberculosis (Mtb) is the leading cause of death from infection worldwide 1 . The only available vaccine, BCG (Bacillus Calmette–Guérin), is…”
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Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization by Gideon, Hannah Priyadarshini, Phuah, JiaYao, Myers, Amy J, Bryson, Bryan D, Rodgers, Mark A, Coleman, M Teresa, Maiello, Pauline, Rutledge, Tara, Marino, Simeone, Fortune, Sarah M, Kirschner, Denise E, Lin, Philana Ling, Flynn, JoAnne L

“…Lung granulomas are the pathologic hallmark of tuberculosis (TB). T cells are a major cellular component of TB lung granulomas and are known to play an…”
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PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis by Lin, Philana Ling, Maiello, Pauline, Gideon, Hannah P, Coleman, M Teresa, Cadena, Anthony M, Rodgers, Mark A, Gregg, Robert, O'Malley, Melanie, Tomko, Jaime, Fillmore, Daniel, Frye, L James, Rutledge, Tara, DiFazio, Robert M, Janssen, Christopher, Klein, Edwin, Andersen, Peter L, Fortune, Sarah M, Flynn, JoAnne L

“…Mycobacterium tuberculosis infection presents across a spectrum in humans, from latent infection to active tuberculosis. Among those with latent tuberculosis,…”
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Widespread Virus Replication in Alveoli Drives Acute Respiratory Distress Syndrome in Aerosolized H5N1 Influenza Infection of Macaques by Wonderlich, Elizabeth R, Swan, Zachary D, Bissel, Stephanie J, Hartman, Amy L, Carney, Jonathan P, O'Malley, Katherine J, Obadan, Adebimpe O, Santos, Jefferson, Walker, Reagan, Sturgeon, Timothy J, Frye, Jr, Lonnie J, Maiello, Pauline, Scanga, Charles A, Bowling, Jennifer D, Bouwer, Anthea L, Duangkhae, Parichat A, Wiley, Clayton A, Flynn, JoAnne L, Wang, Jieru, Cole, Kelly S, Perez, Daniel R, Reed, Douglas S, Barratt-Boyes, Simon M

“…Human infections with highly pathogenic avian influenza A (H5N1) virus are frequently fatal but the mechanisms of disease remain ill-defined. H5N1 infection is…”
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Concurrent infection with Mycobacterium tuberculosis confers robust protection against secondary infection in macaques by Cadena, Anthony M, Hopkins, Forrest F, Maiello, Pauline, Carey, Allison F, Wong, Eileen A, Martin, Constance J, Gideon, Hannah P, DiFazio, Robert M, Andersen, Peter, Lin, Philana Ling, Fortune, Sarah M, Flynn, JoAnne L

“…For many pathogens, including most targets of effective vaccines, infection elicits an immune response that confers significant protection against reinfection…”
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Lymph nodes are sites of prolonged bacterial persistence during Mycobacterium tuberculosis infection in macaques by Ganchua, Sharie Keanne C, Cadena, Anthony M, Maiello, Pauline, Gideon, Hannah P, Myers, Amy J, Junecko, Beth F, Klein, Edwin C, Lin, Philana Ling, Mattila, Joshua T, Flynn, JoAnne L

“…Tuberculosis is commonly considered a chronic lung disease, however, extrapulmonary infection can occur in any organ. Even though lymph nodes (LN) are among…”
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SIV and Mycobacterium tuberculosis synergy within the granuloma accelerates the reactivation pattern of latent tuberculosis by Diedrich, Collin R, Rutledge, Tara, Maiello, Pauline, Baranowski, Tonilynn M, White, Alexander G, Borish, H. Jacob, Karell, Paul, Hopkins, Forrest, Brown, Jessica, Fortune, Sarah M, Flynn, JoAnne L, Ambrose, Zandrea, Lin, Philana Ling

“…Human immunodeficiency virus infection is the most common risk factor for severe forms of tuberculosis (TB), regardless of CD4 T cell count. Using a…”
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MAIT cells are functionally impaired in a Mauritian cynomolgus macaque model of SIV and Mtb co-infection by Ellis, Amy L, Balgeman, Alexis J, Larson, Erica C, Rodgers, Mark A, Ameel, Cassaundra, Baranowski, Tonilynn, Kannal, Nadean, Maiello, Pauline, Juno, Jennifer A, Scanga, Charles A, O'Connor, Shelby L

“…Mucosal-associated invariant T (MAIT) cells can recognize and respond to some bacterially infected cells. Several in vitro and in vivo models of Mycobacterium…”
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Macrophages and neutrophils express IFNλs in granulomas from Mycobacterium tuberculosis-infected nonhuman primates by Talukdar, Priyanka, Junecko, Beth F., Lane, Daniel S., Maiello, Pauline, Mattila, Joshua T.

“…Granulomas are the hallmark of Mycobacterium tuberculosis (Mtb) infection. Cytokine-mediated signaling can modulate immune function; thus, understanding the…”
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Optimizing tuberculosis treatment efficacy: Comparing the standard regimen with Moxifloxacin-containing regimens by Budak, Maral, Cicchese, Joseph M, Maiello, Pauline, Borish, H Jacob, White, Alexander G, Chishti, Harris B, Tomko, Jaime, Frye, L James, Fillmore, Daniel, Kracinovsky, Kara, Sakal, Jennifer, Scanga, Charles A, Lin, Philana Ling, Dartois, Véronique, Linderman, Jennifer J, Flynn, JoAnne L, Kirschner, Denise E

“…Tuberculosis (TB) continues to be one of the deadliest infectious diseases in the world, causing ~1.5 million deaths every year. The World Health Organization…”
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Mycobacterium tuberculosis-Specific CD4 T Cells Expressing Transcription Factors T-Bet or RORγT Associate with Bacterial Control in Granulomas by Grant, Nicole L, Kelly, Kristen, Maiello, Pauline, Abbott, Helena, O'Connor, Shelby, Lin, Philana Ling, Scanga, Charles A, Flynn, JoAnne L

“…Despite the extensive research on CD4 T cells within the context of Mycobacterium tuberculosis (Mtb) infections, few studies have focused on identifying and…”
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T cell transcription factor expression evolves over time in granulomas from Mycobacterium tuberculosis-infected cynomolgus macaques by Grant, Nicole L., Maiello, Pauline, Klein, Edwin, Lin, Philana Ling, Borish, H. Jacob, Tomko, Jaime, Frye, L. James, White, Alexander G., Kirschner, Denise E., Mattila, Joshua T., Flynn, JoAnne L.

“…Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a global health concern, yearly resulting in 10 million new cases of active TB…”
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Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques by Winchell, Caylin G, Mishra, Bibhuti B, Phuah, Jia Yao, Saqib, Mohd, Nelson, Samantha J, Maiello, Pauline, Causgrove, Chelsea M, Ameel, Cassaundra L, Stein, Brianne, Borish, H Jacob, White, Alexander G, Klein, Edwin C, Zimmerman, Matthew D, Dartois, Véronique, Lin, Philana Ling, Sassetti, Christopher M, Flynn, JoAnne L

“…In 2017 over 550,000 estimated new cases of multi-drug/rifampicin resistant tuberculosis (MDR/RR-TB) occurred, emphasizing a need for new treatment strategies…”
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Boosting BCG with proteins or rAd5 does not enhance protection against tuberculosis in rhesus macaques by Darrah, Patricia A., DiFazio, Robert M., Maiello, Pauline, Gideon, Hannah P., Myers, Amy J., Rodgers, Mark A., Hackney, Joshua A., Lindenstrom, Thomas, Evans, Thomas, Scanga, Charles A., Prikhodko, Victor, Andersen, Peter, Lin, Philana Ling, Laddy, Dominick, Roederer, Mario, Seder, Robert A., Flynn, JoAnne L.

“…Tuberculosis (TB) is the leading cause of death from infection worldwide. The only approved vaccine, BCG, has variable protective efficacy against pulmonary…”
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Profiling the airway in the macaque model of tuberculosis reveals variable microbial dysbiosis and alteration of community structure by Cadena, Anthony M, Ma, Yixuan, Ding, Tao, Bryant, MacKenzie, Maiello, Pauline, Geber, Adam, Lin, Philana Ling, Flynn, JoAnne L, Ghedin, Elodie

“…The specific interactions of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), and the lung microbiota in infection are entirely…”
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Spontaneous Control of SIV Replication Does Not Prevent T Cell Dysregulation and Bacterial Dissemination in Animals Co-Infected with M. tuberculosis by Moriarty, Ryan V, Rodgers, Mark A, Ellis, Amy L, Balgeman, Alexis J, Larson, Erica C, Hopkins, Forrest, Chase, Michael R, Maiello, Pauline, Fortune, Sarah M, Scanga, Charles A, O'Connor, Shelby L

“…Individuals co-infected with HIV and Mycobacterium tuberculosis (Mtb) are more likely to develop severe tuberculosis (TB) disease than HIV-naive individuals…”
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Positron Emission Tomography Imaging of Macaques with Tuberculosis Identifies Temporal Changes in Granuloma Glucose Metabolism and Integrin α4β1-Expressing Immune Cells by Mattila, Joshua T, Beaino, Wissam, Maiello, Pauline, Coleman, M Teresa, White, Alexander G, Scanga, Charles A, Flynn, JoAnne L, Anderson, Carolyn J

“…Positron emission tomography and computed tomography imaging (PET/CT) is an increasingly valuable tool for diagnosing tuberculosis (TB). The glucose analog […”
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Characterization of a potential host-directed therapy against TB in non-human primates by Winchell, Caylin G, Maiello, Pauline A., Flynn, JoAnne L

“…Abstract An estimated 558,000 cases of drug-resistant tuberculosis (TB) occurred in 2017, emphasizing a need for new treatment strategies. We assessed a…”
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Early Changes by (18)Fluorodeoxyglucose positron emission tomography coregistered with computed tomography predict outcome after Mycobacterium tuberculosis infection in cynomolgus macaques by Coleman, M Teresa, Maiello, Pauline, Tomko, Jaime, Frye, Lonnie James, Fillmore, Daniel, Janssen, Christopher, Klein, Edwin, Lin, Philana Ling

“…Cynomolgus macaques infected with low-dose Mycobacterium tuberculosis develop both active tuberculosis and latent infection similar to those of humans,…”
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Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison by Maiello, Pauline, DiFazio, Robert M, Cadena, Anthony M, Rodgers, Mark A, Lin, Philana Ling, Scanga, Charles A, Flynn, JoAnne L

“…In the past 2 decades, it has become increasingly clear that nonhuman primates, specifically macaques, are useful models for human tuberculosis (TB). Several…”
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