Search Results - "Maianu, L."

Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance by Garvey, W T, Maianu, L, Zhu, J H, Brechtel-Hook, G, Wallace, P, Baron, A D

“…Insulin resistance is instrumental in the pathogenesis of type 2 diabetes mellitus and the Insulin Resistance Syndrome. While insulin resistance involves…”
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Glucosamine induces insulin resistance in vivo by affecting GLUT 4 translocation in skeletal muscle. Implications for glucose toxicity by Baron, A D, Zhu, J S, Zhu, J H, Weldon, H, Maianu, L, Garvey, W T

“…Glucosamine (Glmn), a product of glucose metabolism via the hexosamine pathway, causes insulin resistance in isolated adipocytes by impairing insulin-induced…”
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Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM by Garvey, W. T., Maianu, L., Hancock, J. A., Golichowski, A. M., Baron, A.

“…Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. W T Garvey , L Maianu , J A Hancock , A M…”
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Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM by GARVEY, W. T, MAIANU, L, HANCOCK, J. A, GOLICHOWSKI, A. M, BARON, A

“…In obesity, impaired glucose tolerance (IGT), non-insulin-dependent diabetes mellitus (NIDDM), and gestational diabetes mellitus (GDM), defects in glucose…”
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Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters by Garvey, W. T., Maianu, L., Zhu, J. H., Hancock, J. A., Golichowski, A. M.

“…Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel…”
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Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesity by GARVEY, W. T, MAIANU, L, HUECKSTEADT, T. P, BIRNBAUM, M. J, MOLINA, J. M, CIARALDI, T. P

“…A major portion of insulin-mediated glucose uptake occurs via the translocation of GLUT 4 glucose transporter proteins from an intracellular depot to the…”
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Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes : heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters by GARVEY, W. T, MAIANY, L, JU-HONG ZHU, HANCOCK, J. A, GOLICHOWSKI, A. M

“…Mechanisms causing cellular insulin resistance in gestational diabetes mellitus are not known. We, therefore, studied isolated omental adipocytes obtained…”
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Molecular adaptations of GLUT1 and GLUT2 in renal proximal tubules of diabetic rats by Dominguez, J.H, Camp, K, Maianu, L, Feister, H, Garvey, W.T

“…The renal reabsorption of glucose is mediated by two major classes of transporters. Initially, luminal glucose is concentrated in tubules by Na+-glucose…”
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Glucose and insulin chronically regulate insulin action via different mechanisms in BC3H1 myocytes. Effects on glucose transporter gene expression by Mayor, P., Maianu, L., Garvey, W. T.

“…Glucose and insulin chronically regulate insulin action via different mechanisms in BC3H1 myocytes. Effects on glucose transporter gene expression. P Mayor , L…”
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Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition by Garvey, W. T., Maianu, L., Kennedy, A., Wallace, P., Ganaway, E., Hamacher, L. L., Yarnall, D. P., Lenhard, J. M., Burns, D. K.

“…Muscle Rad expression and human metabolism: potential role of the novel Ras-related GTPase in energy expenditure and body composition. W T Garvey , L Maianu ,…”
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Glucose and insulin chronically regulate insulin action via different mechanisms in BC3H1 myocytes : effects on glucose transporter gene expression by MAYOR, P, MAIANU, L, GARVEY, W. T

“…We previously reported that, in primary cultured adipocytes, chronic exposure to glucose plus insulin impairs the insulin-responsive glucose transport system…”
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Glucose transporters of rat proximal tubule: differential expression and subcellular distribution by Dominguez, J H, Camp, K, Maianu, L, Garvey, W T

“…In the late proximal tubule, glucose reabsorption progressively lowers the concentration of luminal glucose, and concentrative glucose influx increases to…”
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Facilitative glucose transporter gene expression in human lymphocytes, monocytes, and macrophages: a role for GLUT isoforms 1, 3, and 5 in the immune response and foam cell formation by Fu, Yuchang, Maianu, Lidia, Melbert, Barry R, Garvey, W.Timothy

“…Cellular glucose uptake is mediated by a family of facilitative glucose transporters (GLUT) exhibiting differences in kinetics, substrate specificity, and…”
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Adipocytes Exhibit Abnormal Subcellular Distribution and Translocation of Vesicles Containing Glucose Transporter 4 and Insulin-Regulated Aminopeptidase in Type 2 Diabetes Mellitus: Implications Regarding Defects in Vesicle Trafficking by Maianu, Lidia, Keller, Susanna R., Garvey, W. Timothy

“…Insulin resistance in type 2 diabetes is due to impaired stimulation of the glucose transport system in muscle and fat. Different defects are operative in…”
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Mechanisms of enhanced insulin sensitivity in endurance-trained athletes: effects on blood flow and differential expression of GLUT 4 in skeletal muscles by Hardin, D S, Azzarelli, B, Edwards, J, Wigglesworth, J, Maianu, L, Brechtel, G, Johnson, A, Baron, A, Garvey, W T

“…Exercise is associated with increased insulin sensitivity. To better understand mechanisms that could be responsible for this association, we studied seven…”
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Gene expression of epithelial glucose transporters: the role of diabetes mellitus by Dominguez, J H, Song, B, Maianu, L, Garvey, W T, Qulali, M

“…The functions of absorption of dietary glucose by the small intestine and reabsorption of filtered glucose by the renal proximal tubule are strikingly similar…”
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Glucose and insulin chronically regulate insulin action via different mechanisms in BC sub(3)H1 myocytes. Effects on glucose transporter gene expression by Mayor, P, Maianu, L, Garvey, W T

“…In BC sub(3)H1 myocytes 1) glucose diminished insulin sensitivity by decreasing insulin receptor binding affinity and decreased basal and maximally…”
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Muscle Rad expression and human metabolism: Potential role of the novel ras-related GTPase in energy expenditure and body composition by GARVEY, W. T, MAIANU, L, KENNEDY, A, WALLACE, P, GANAWAY, E, HAMACHER, L. L, YARNALL, D. P, LENHARD, J. M, BURNS, D. K

“…Ras associated with diabetes (Rad), a new ras-related GTPase, was recently identified by subtractive cloning as an mRNA in skeletal muscle that is…”
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Identification of Rad's effector-binding domain, intracellular localization, and analysis of expression in Pima Indians by Paulik, Mark A., Hamacher, Lawrence L., Yarnall, David P., Simmons, Caroline J., Maianu, Lidia, Pratley, Richard E., Garvey, W. Timothy, Burns, Daniel K., Lenhard, James M.

“…In order to characterize the endogenous gene product for rad (ras‐related protein associated with diabetes), we prepared antibodies to synthetic peptides that…”
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Potential role for insulin and cycloheximide in regulating the intrinsic activity of glucose transporters in isolated rat adipocytes by Karnieli, E, Garvey, W T, Olefsky, J M, Hueckstead, T P, Harel, C, Maianu, L, Armoni, M

“…We examined the hypothesis that insulin stimulation of cellular glucose transport may involve a protein synthesis-dependent regulation of glucose transporter…”
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