The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study

In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategies. Therefore, to evaluate the role of excessive fluid infusion in a general population with...

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Published in:	Critical care (London, England) Vol. 17; no. 6; p. R288
Main Authors:	Silva, Jr, João M, de Oliveira, Amanda Maria Ribas Rosa, Nogueira, Fernando Augusto Mendes, Vianna, Pedro Monferrari Monteiro, Pereira Filho, Marcos Cruz, Dias, Leandro Ferreira, Maia, Vivian Paz Leão, Neucamp, Cesar de Souza, Amendola, Cristina Prata, Carmona, Maria José Carvalho, Malbouisson, Luiz M Sá
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 10-12-2013 BioMed Central
Subjects:	Aged Complications Female Fluid Therapy - adverse effects Hospital Mortality Humans Intensive Care Units Intraoperative Period Male Middle Aged Osmoregulation Palliative treatment Perioperative Care Postoperative Complications - mortality Prospective Studies Risk Factors Surgery Time Factors Water-Electrolyte Balance Water-electrolyte balance (Physiology) Brazil
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Summary:	In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategies. Therefore, to evaluate the role of excessive fluid infusion in a general population with high-risk surgery is very important. The aim of this study was to evaluate the impact of intraoperative fluid balance on the postoperative organ dysfunction, infection and mortality rate. We conducted a prospective cohort study during one year in four ICUs from three tertiary hospitals, which included patients aged 18 years or more who required postoperative ICU after undergoing major surgery. Patients who underwent palliative surgery and whose fluid balance could change in outcome were excluded. The calculation of fluid balance was based on preoperative fasting, insensible losses from surgeries and urine output minus fluid replacement intraoperatively. The study included 479 patients. Mean age was 61.2 ± 17.0 years and 8.8% of patients died at the hospital during the study. The median duration of surgery was 4.0 (3.2 to 5.5) h and the value of the Simplified Acute Physiology Score (SAPS) 3 score was 41.8 ± 14.5. Comparing survivors and non-survivors, the intraoperative fluid balance from non-survivors was higher (1,950 (1,400 to 3,400) mL vs. 1,400 (1,000 to 1,600) mL, P <0.001). Patients with fluid balance above 2,000 mL intraoperatively had a longer ICU stay (4.0 (3.0 to 8.0) vs. 3.0 (2.0 to 6.0), P <0.001) and higher incidence of infectious (41.9% vs. 25.9%, P = 0.001), neurological (46.2% vs. 13.2%, P <0.001), cardiovascular (63.2% vs. 39.6%, P <0.001) and respiratory complications (34.3% vs. 11.6%, P <0.001). In multivariate analysis, the fluid balance was an independent factor for death (OR per 100 mL = 1.024; P = 0.006; 95% CI 1.007 to 1.041). Patients with excessive intraoperative fluid balance have more ICU complications and higher hospital mortality.
ISSN:	1364-8535 1466-609X 1364-8535
DOI:	10.1186/cc13151