Effects of Extended Treatment with Protium heptaphyllum Liposomes on Metabolic Parameters of Obese Rats

( ), popularly known as "almacega" or "white pitch", is widely used in folk medicine due to its antioxidant, anti-inflammatory and healing properties, attributed to its richness in flavonoids and terpenes. Therefore, this study aimed to evaluate the effects of treatment for 28 da...

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Published in:	Biology (Basel, Switzerland) Vol. 13; no. 10; p. 771
Main Authors:	Patias, Naiéle Sartori, Maia, Sara Vieira, Ferreira, Yasmin Gabriele, de Oliveira, Natalhya Letícia Ferreira, Ferrarini, Stela Regina, Bomfim, Gisele Facholi, Sinhorin, Adilson Paulo, Aguiar, Danilo Henrique, de Queiroz, Eveline Aparecida Isquierdo Fonseca, Sinhorin, Valéria Dornelles Gindri
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 27-09-2024 MDPI
Subjects:	Adipose tissue Alanine transaminase Alkaline phosphatase Analgesics Animal models Animals Antioxidants Aspartate aminotransferase Biological products Body fat Brazil Creatinine Dextrose Diabetes Eating behavior Epidemics Fatty liver Flavonoids Food Free radicals Glucose Glutathione transferase hypercaloric diet Inflammation Interleukins Isoflavones Leaves Liposomes Medical research Medicinal plants Medicine, Botanic Medicine, Herbal Metabolic disorders Natural products Obesity Oxidative stress phytotherapeutic treatment Plant extracts quercetrin Reactive oxygen species Redox properties Resins Steatosis Sucrose Superoxide Superoxide dismutase Terpenes Traditional medicine Type 2 diabetes Brazil hypercaloric diet phytotherapeutic treatment quercetrin oxidative stress
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Summary:	( ), popularly known as "almacega" or "white pitch", is widely used in folk medicine due to its antioxidant, anti-inflammatory and healing properties, attributed to its richness in flavonoids and terpenes. Therefore, this study aimed to evaluate the effects of treatment for 28 days with liposomes containing leaf extract in obese animals. Male Wistar rats, subjected to a hypercaloric diet for 8 weeks to induce obesity (hypercaloric chow and water enriched with 30% sucrose, ad libitum), were treated with the plant formulation (1 mg kg day , via gavage) for 28 days. The study investigated morphological, metabolic, redox state, immunological and histological parameters in adipose and liver tissue. Rats were divided into four groups: control (C), liposomes with extract (H), obese (O) and obese treated with liposomes containing extract (OH). The results indicated that the obese group (O) presented weight gain, hepatic steatosis and alterations in metabolic and inflammatory parameters. However, treatment with liposomes (OH) reduced glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine and the lipid profile. In adipose tissue, the OH group showed decreased superoxide dismutase (SOD) activity and increased glutathione S-transferase (GST) activity, in contrast to the effects observed in liver GST. In the analysis of thiobarbituric-acid-reactive substances (TBARS), it was possible to observe an increase in all groups in adipose tissue and in group O in liver tissue, in addition to a reduction in TBARS in group OH in the liver, indicating modulation of oxidative stress. The treatment also increased the concentration of IL-10 and IL-17 in the liver and decreased that of IL-6 in adipose tissue. After 28 days of treatment, these results point to the therapeutic potential of treatment with , not necessarily only against obesity, but also an effect per se of the liposomes, possibly due to the high concentration of flavonoids present in the plant extract.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2079-7737 2079-7737
DOI:	10.3390/biology13100771