Search Results - "Mahurkar, Anup"

Advancing discovery in hearing research via biologist-friendly access to multi-omic data by Hertzano, Ronna, Mahurkar, Anup

“…High-throughput cell type-specific multi-omic analyses have advanced our understanding of inner ear biology in an unprecedented way. The full benefit of these…”
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Strains, functions and dynamics in the expanded Human Microbiome Project by Lloyd-Price, Jason, Mahurkar, Anup, Rahnavard, Gholamali, Crabtree, Jonathan, Orvis, Joshua, Hall, A. Brantley, Brady, Arthur, Creasy, Heather H., McCracken, Carrie, Giglio, Michelle G., McDonald, Daniel, Franzosa, Eric A., Knight, Rob, White, Owen, Huttenhower, Curtis

“…The characterization of baseline microbial and functional diversity in the human microbiome has enabled studies of microbiome-related disease, diversity,…”
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Brain feminization requires active repression of masculinization via DNA methylation by Nugent, Bridget M, Wright, Christopher L, Shetty, Amol C, Hodes, Georgia E, Lenz, Kathryn M, Mahurkar, Anup, Russo, Scott J, Devine, Scott E, McCarthy, Margaret M

“…Hormone-induced brain masculinization occurs during a perinatal sensitive period but endures into adulthood. Researchers explored DNA methylation as a…”
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gEAR: Gene Expression Analysis Resource portal for community-driven, multi-omic data exploration by Orvis, Joshua, Gottfried, Brian, Kancherla, Jayaram, Adkins, Ricky S., Song, Yang, Dror, Amiel A., Olley, Dustin, Rose, Kevin, Chrysostomou, Elena, Kelly, Michael C., Milon, Beatrice, Matern, Maggie S., Azaiez, Hela, Herb, Brian, Colantuoni, Carlo, Carter, Robert L., Ament, Seth A., Kelley, Matthew W., White, Owen, Bravo, Hector Corrada, Mahurkar, Anup, Hertzano, Ronna

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CD34 defines melanocyte stem cell subpopulations with distinct regenerative properties by Joshi, Sandeep S, Tandukar, Bishal, Pan, Li, Huang, Jennifer M, Livak, Ferenc, Smith, Barbara J, Hodges, Theresa, Mahurkar, Anup A, Hornyak, Thomas J

“…Melanocyte stem cells (McSCs) are the undifferentiated melanocytic cells of the mammalian hair follicle (HF) responsible for recurrent generation of a large…”
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The Neuroscience Multi-Omic Archive: a BRAIN Initiative resource for single-cell transcriptomic and epigenomic data from the mammalian brain by Ament, Seth A, Adkins, Ricky S, Carter, Robert, Chrysostomou, Elena, Colantuoni, Carlo, Crabtree, Jonathan, Creasy, Heather H, Degatano, Kylee, Felix, Victor, Gandt, Peter, Garden, Gwenn A, Giglio, Michelle, Herb, Brian R, Khajouei, Farzaneh, Kiernan, Elizabeth, McCracken, Carrie, McDaniel, Kennedy, Nadendla, Suvarna, Nickel, Lance, Olley, Dustin, Orvis, Joshua, Receveur, Joseph P, Schor, Mike, Sonthalia, Shreyash, Tickle, Timothy L, Way, Jessica, Hertzano, Ronna, Mahurkar, Anup A, White, Owen R

“…Scalable technologies to sequence the transcriptomes and epigenomes of single cells are transforming our understanding of cell types and cell states. The Brain…”
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Best practices on the differential expression analysis of multi-species RNA-seq by Chung, Matthew, Bruno, Vincent M, Rasko, David A, Cuomo, Christina A, Muñoz, José F, Livny, Jonathan, Shetty, Amol C, Mahurkar, Anup, Dunning Hotopp, Julie C

“…Advances in transcriptome sequencing allow for simultaneous interrogation of differentially expressed genes from multiple species originating from a single RNA…”
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Mutagenesis of human genomes by endogenous mobile elements on a population scale by Chuang, Nelson T, Gardner, Eugene J, Terry, Diane M, Crabtree, Jonathan, Mahurkar, Anup A, Rivell, Guillermo L, Hong, Charles C, Perry, James A, Devine, Scott E

“…Several large-scale Illumina whole-genome sequencing (WGS) and whole-exome sequencing (WES) projects have emerged recently that have provided exceptional…”
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Natural genetic variation caused by small insertions and deletions in the human genome by Mills, Ryan E, Pittard, W Stephen, Mullaney, Julienne M, Farooq, Umar, Creasy, Todd H, Mahurkar, Anup A, Kemeza, David M, Strassler, Daniel S, Ponting, Chris P, Webber, Caleb, Devine, Scott E

“…Human genetic variation is expected to play a central role in personalized medicine. Yet only a fraction of the natural genetic variation that is harbored by…”
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A comparative analysis of library prep approaches for sequencing low input translatome samples by Song, Yang, Milon, Beatrice, Ott, Sandra, Zhao, Xuechu, Sadzewicz, Lisa, Shetty, Amol, Boger, Erich T, Tallon, Luke J, Morell, Robert J, Mahurkar, Anup, Hertzano, Ronna

“…Cell type-specific ribosome-pulldown has become an increasingly popular method for analysis of gene expression. It allows for expression analysis from intact…”
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Reprogramming Chromosome Ends by Functional Histone Acetylation by Meltzer, W Alex, Gupta, Aditi, Lin, Phyo Nay, Brown, Robert A, Benyamien-Roufaeil, Daniel S, Khatri, Raju, Mahurkar, Anup A, Song, Yang, Taylor, Rodney J, Zalzman, Michal

“…Cancers harness embryonic programs to evade aging and promote survival. Normally, sequences at chromosome ends called telomeres shorten with cell division,…”
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Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia by Emadi, Ashkan, Kapadia, Bandish, Bollino, Dominique, Bhandary, Binny, Baer, Maria R., Niyongere, Sandrine, Strovel, Erin T., Kaizer, Hannah, Chang, Elizabeth, Choi, Eun Yong, Ma, Xinrong, Tighe, Kayla M., Carter-Cooper, Brandon, Moses, Blake S., Civin, Curt I., Mahurkar, Anup, Shetty, Amol C., Gartenhaus, Ronald B., Kamangar, Farin, Lapidus, Rena G.

“…Complex karyotype acute myeloid leukemia (CK-AML) has a dismal outcome with current treatments, underscoring the need for new therapies. Here, we report…”
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Microtubules underlie dysfunction in duchenne muscular dystrophy by Khairallah, Ramzi J, Shi, Guoli, Sbrana, Francesca, Prosser, Benjamin L, Borroto, Carlos, Mazaitis, Mark J, Hoffman, Eric P, Mahurkar, Anup, Sachs, Fredrick, Sun, Yezhou, Chen, Yi-Wen, Raiteri, Roberto, Lederer, W Jonathan, Dorsey, Susan G, Ward, Christopher W

“…Duchenne muscular dystrophy (DMD) is a fatal X-linked degenerative muscle disease caused by the absence of the microtubule-associated protein dystrophin, which…”
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Peripheral blood transcriptomic profiling of molecular mechanisms commonly regulated by binge drinking and placebo effects by Shetty, Amol Carl, Sivinski, John, Cornell, Jessica, McCracken, Carrie, Sadzewicz, Lisa, Mahurkar, Anup, Wang, Xing-Qun, Colloca, Luana, Lin, Weihong, Pilli, Nageswara, Kane, Maureen A., Seneviratne, Chamindi

“…Molecular responses to alcohol consumption are dynamic, context-dependent, and arise from a complex interplay of biological and external factors. While many…”
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Functional dynamics of the gut microbiome in elderly people during probiotic consumption by Eloe-Fadrosh, Emiley A, Brady, Arthur, Crabtree, Jonathan, Drabek, Elliott F, Ma, Bing, Mahurkar, Anup, Ravel, Jacques, Haverkamp, Miriam, Fiorino, Anne-Maria, Botelho, Christine, Andreyeva, Irina, Hibberd, Patricia L, Fraser, Claire M

“…A mechanistic understanding of the purported health benefits conferred by consumption of probiotic bacteria has been limited by our knowledge of the resident…”
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MAMS: matrix and analysis metadata standards to facilitate harmonization and reproducibility of single-cell data by Sarfraz, Irzam, Wang, Yichen, Shastry, Amulya, Teh, Wei Kheng, Sokolov, Artem, Herb, Brian R, Creasy, Heather H, Virshup, Isaac, Dries, Ruben, Degatano, Kylee, Mahurkar, Anup, Schnell, Daniel J, Madrigal, Pedro, Hilton, Jason, Gehlenborg, Nils, Tickle, Timothy, Campbell, Joshua D

“…Many datasets are being produced by consortia that seek to characterize healthy and disease tissues at single-cell resolution. While biospecimen and…”
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The miRNA Expression Profile of Experimental Autoimmune Encephalomyelitis Reveals Novel Potential Disease Biomarkers by Venkatesha, Shivaprasad H, Dudics, Steven, Song, Yang, Mahurkar, Anup, Moudgil, Kamal D

“…Multiple sclerosis (MS) is a debilitating autoimmune disease affecting over 2.3 million people worldwide, and it is characterized by inflammation and…”
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Cardiomyocyte-specific perilipin 5 overexpression leads to myocardial steatosis and modest cardiac dysfunction by Wang, Hong, Sreenivasan, Urmila, Gong, Da-Wei, O'Connell, Kelly A, Dabkowski, Erinne R, Hecker, Peter A, Ionica, Nicoleta, Konig, Manige, Mahurkar, Anup, Sun, Yezhou, Stanley, William C, Sztalryd, Carole

“…Presence of ectopic lipid droplets (LDs) in cardiac muscle is associated to lipotoxicity and tissue dysfunction. However, presence of LDs in heart is also…”
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New signaling pathways govern the host response to C. albicans infection in various niches by Liu, Yaoping, Shetty, Amol C, Schwartz, Jennifer A, Bradford, L Latey, Xu, Wenjie, Phan, Qyunh T, Kumari, Priti, Mahurkar, Anup, Mitchell, Aaron P, Ravel, Jacques, Fraser, Claire M, Filler, Scott G, Bruno, Vincent M

“…Candida albicans, the major invasive fungal pathogen of humans, can cause both debilitating mucosal infections and fatal invasive infections. Understanding the…”
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Contextual in situ help for visual data interfaces by Chundury, Pramod, Yalçin, Mehmet Adil, Crabtree, Jonathan, Mahurkar, Anup, Shulman, Lisa M, Elmqvist, Niklas

“…As the complexity of data analysis increases, even well-designed data interfaces must guide experts in transforming their theoretical knowledge into actual…”
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