Search Results - "Mahrukh, M."

Development of Novel Mutation-Specific Droplet Digital PCR Assays Detecting TERT Promoter Mutations in Tumor and Plasma Samples by Corless, Broderick C., Chang, Gregory A., Cooper, Samantha, Syeda, Mahrukh M., Shao, Yongzhao, Osman, Iman, Karlin-Neumann, George, Polsky, David

“…Detecting mutations in the plasma of patients with solid tumors is becoming a valuable method of diagnosing and monitoring cancer. The TERT promoter is mutated…”
Get full text

Circulating tumour DNA in patients with advanced melanoma treated with dabrafenib or dabrafenib plus trametinib: a clinical validation study by Syeda, Mahrukh M, Wiggins, Jennifer M, Corless, Broderick C, Long, Georgina V, Flaherty, Keith T, Schadendorf, Dirk, Nathan, Paul D, Robert, Caroline, Ribas, Antoni, Davies, Michael A, Grob, Jean Jacques, Gasal, Eduard, Squires, Matthew, Marker, Mahtab, Garrett, James, Brase, Jan C, Polsky, David

“…Melanoma lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Cell-free circulating tumour DNA (ctDNA) is a promising…”
Get full text

Inhibition of Prostaglandin Transporter (PGT) Promotes Perfusion and Vascularization and Accelerates Wound Healing in Non-Diabetic and Diabetic Rats by Liu, Zhongbo, Benard, Outhiriaradjou, Syeda, Mahrukh M, Schuster, Victor L, Chi, Yuling

“…Peripheral ischemia, resulting from diminished arterial flow and defective local vascularization, is one of the main causes of impaired wound healing in…”
Get full text

Prostaglandin Transporter Modulates Wound Healing in Diabetes by Regulating Prostaglandin-Induced Angiogenesis by Syeda, Mahrukh M, Jing, Xiaohong, Mirza, Raihan H, Yu, Hong, Sellers, Rani S, Chi, Yuling

“…Prostaglandin transporter (PGT) mediates prostaglandin (PG) catabolism and PG signal termination. The prostanoid PGE2 , which induces angiogenesis and…”
Get full text

TERT, BRAF, and NRAS Mutational Heterogeneity between Paired Primary and Metastatic Melanoma Tumors by Chang, Gregory A., Wiggins, Jennifer M., Corless, Broderick C., Syeda, Mahrukh M., Tadepalli, Jyothirmayee S., Blake, Shria, Fleming, Nathaniel, Darvishian, Farbod, Pavlick, Anna, Berman, Russell, Shapiro, Richard, Shao, Yongzhao, Karlin-Neumann, George, Spittle, Cindy, Osman, Iman, Polsky, David

“…Mutational heterogeneity can contribute to therapeutic resistance in solid cancers. In melanoma, the frequencies of intertumoral and intratumoral heterogeneity…”
Get full text

Validation of Circulating Tumor DNA Assays for Detection of Metastatic Melanoma by Syeda, Mahrukh M, Wiggins, Jennifer M, Corless, Broderick, Spittle, Cindy, Karlin-Neumann, George, Polsky, David

“…The detection of cell-free, circulating tumor DNA (ctDNA) in the blood of patients with solid tumors is often referred to as "liquid biopsy." ctDNA is…”
Get more information

Numerical investigation of heat transfer by an impinging jet using alumina-water nanofluid by Allauddin, U., Mahrukh, M., Rehman, N. U., Haque, M. E., Uddin, N.

“…This article reports numerical investigations of turbulent flow field and heat transfer performance of water-alumina nanofluid jet impingement. The jet…”
Get full text

Prediction of breast cancer risk based on flow-variant analysis of circulating peripheral blood B cells by Syeda, Mahrukh M., Upadhyay, Kinnari, Loke, Johnny, Pearlman, Alexander, Klugman, Susan, Shao, Yongzhao, Ostrer, Harry

“…Purpose: Identifying women at high risk for breast cancer can trigger a personal program of annual mammograms and magnetic resonance imaging scans for early…”
Get full text

801 Overexpression of human TLR8 induces bone marrow dysfunction and severe anemia in lupus- prone mice by Maria, Naomi I, Papoin, Julien, Raparia, Chirag, Sun, Zeguo, Josselsohn, Rachel, Lu, Ailing, Katerji, Hani, Syeda, Mahrukh M, Polsky, David, Paulson, Robert, Kalfa, Theodosia, Barnes, Betsy J, Zhang, Weijia, Blanc, Lionel, Davidson, Anne

“…Anemia commonly occurs in systemic lupus erythematosus (SLE), a disease characterized by innate immune activation by nucleic acids. Overactivation of…”
Get full text

Human TLR8 induces inflammatory bone marrow erythromyeloblastic islands and anemia in SLE-prone mice by Maria, Naomi I, Papoin, Julien, Raparia, Chirag, Sun, Zeguo, Josselsohn, Rachel, Lu, Ailing, Katerji, Hani, Syeda, Mahrukh M, Polsky, David, Paulson, Robert, Kalfa, Theodosia, Barnes, Betsy J, Zhang, Weijia, Blanc, Lionel, Davidson, Anne

“…Anemia commonly occurs in systemic lupus erythematosus, a disease characterized by innate immune activation by nucleic acids. Overactivation of cytoplasmic…”
Get full text

A phase II and pharmacodynamic study of gefitinib in patients with refractory or recurrent epithelial ovarian cancer by Posadas, Edwin M., Liel, Meghan S., Kwitkowski, Virginia, Minasian, Lori, Godwin, Andrew K., Hussain, Mahrukh M., Espina, Virginia, Wood, Bradford J., Steinberg, Seth M., Kohn, Elise C.

“…BACKGROUND The primary objective of this study was to evaluate the biochemical effects of gefitinib on its target signal‐transduction pathways in patients with…”
Get full text

Knowledge and attitude towards plagiarism: a comparative study of students from medical and non-medical fields by Memon, Roha S, Ali, Mahrukh M, Zafar, Marium, Shaikh, Asim

“…# Background Research has become a crucial part of restorative sciences. Yet, research ethics are sometimes bypassed. One of the research ethical misconducts,…”
Get full text

A prospective analysis of imatinib-induced c-KIT modulation in ovarian cancer : A phase II clinical study with proteomic profiling by POSADAS, Edwin M, KWITKOWSKI, Virginia, KOHN, Elise C, KOTZ, Herbert L, ESPINA, Virginia, MINASIAN, Lori, TCHABO, Nana, PREMKUMAR, Ahalya, HUSSAIN, Mahrukh M, CHANG, Richard, STEINBERG, Seth M

“…c-Kit and platelet-derived growth factor receptor (PDGFR) are potential molecular targets in epithelial ovarian cancer (EOC). Imatinib inhibits the kinase…”
Get full text

Phase II Trial of Carboxyamidotriazole in Patients With Relapsed Epithelial Ovarian Cancer by HUSSAIN, Mahrukh M, KOTZ, Herbert, FIGG, William D, KOHN, Elise C, MINASIAN, Lori, PREMKUMAR, Ahalya, SAROSY, Gisele, REED, Eddie, SUOPING ZHAI, STEINBERG, Seth M, RAGGIO, Miranda, OLIVER, Vyta Kulpa

“…Carboxyamidotriazole (CAI) is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. It inhibits…”
Get full text

Ten‐year follow‐up of a phase 2 study of dose‐intense paclitaxel with cisplatin and cyclophosphamide as initial therapy for poor‐prognosis, advanced‐stage epithelial ovarian cancer by Sarosy, Gisele A., Hussain, Mahrukh M., Seiden, Michael V., Fuller, Arlan F., Nikrui, Najmosama, Goodman, Annekathryn, Minasian, Lori, Reed, Eddie, Steinberg, Seth M., Kohn, Elise C.

“…BACKGROUND: The objective of this study was to assess activity and toxicity in patients with newly diagnosed, advanced‐stage epithelial ovarian cancer (EOC)…”
Get full text

A prospective analysis of imatinib‐induced c‐kit modulation in ovarian cancer by Posadas, Edwin M., Kwitkowski, Virginia, Kotz, Herbert L., Espina, Virginia, Minasian, Lori, Tchabo, Nana, Premkumar, Ahalya, Hussain, Mahrukh M., Chang, Richard, Steinberg, Seth M., Kohn, Elise C.

“…BACKGROUND. c‐Kit and platelet‐derived growth factor receptor (PDGFR) are potential molecular targets in epithelial ovarian cancer (EOC). Imatinib inhibits the…”
Get full text

Abstract 2239: Analysis of nucleosomal DNA as an extraction control for plasma-based circulating tumor DNA assays by Syeda, Mahrukh M., Karlin-Neumann, George, Osman, Iman, Polsky, David

“…Abstract Purpose: Challenges to accurate quantitative measurements of circulating tumor DNA (ctDNA) include variable contamination with large DNA fragments…”
Get full text

Oxidation protection dynamics of NiAl droplet by inflight in-situ carbon deoxidation during atmospheric plasma spraying for high performance NiAl coatings by Zhang, Li, Mahrukh, M., Wang, Di, Liao, Xian-Jin, Luo, Xiao-Tao, Li, Chang-Jiu

“…The oxidation of the metallic particles in plasma spraying leads to poor inter-lamellar bonding and thereby lower corrosion and high temperature oxidation…”
Get full text

Abstract A66: Analytical validation of 7 droplet digital PCR assays detecting TERT, BRAF, and NRAS hotspot mutations in plasma-derived circulating tumor DNA (ctDNA) by Syeda, Mahrukh M., Corless, Broderick, Osman, Iman, Spittle, Cindy, Karlin-Neumann, George, Polsky, David

“…Abstract Introduction: Serial monitoring of sensitive and specific blood-based biomarkers of disease burden in cancer patients could enable clinicians to…”
Get full text

Association of circulating tumor DNA kinetics with disease recurrence in patients with stage IIIB/C/IV melanoma treated with adjuvant immunotherapy in Checkmate 238 by Syeda, Mahrukh M., Wiggins, Jennifer M, Alegun, Josephine, Ali, Saim, Tang, Hao, Wang, Sheen, Tsai, Kao-Tai, Desai, Keyur, Dolfi, Sonia, Tenney, Daniel J., Ascierto, Paolo Antonio, Larkin, James, Del Vecchio, Michele, Weber, Jeffrey S., Polsky, David

“…9577 Background: In patients (pts) with resected, stage III/IV melanoma receiving adjuvant immunotherapy, pre-treatment (pre-Tx) and on-treatment (on-Tx)…”
Get full text