Regional consensus opinion for the management of Beta thalassemia major in the Arabian Gulf area

Regional consensus opinion for the management of Beta thalassemia major in the Arabian Gulf area

Thalassemia syndrome has diverse clinical presentations and a global spread that has far exceeded the classical Mediterranean basin where the mutations arose. The mutations that give rise to either alpha or beta thalassemia are numerous, resulting in a wide spectrum of clinical severity ranging from...

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Bibliographic Details
Published in:Orphanet journal of rare diseases Vol. 8; no. 1; p. 143
Main Authors: Qari, Mohamad H, Wali, Yasser, Albagshi, Muneer H, Alshahrani, Mohammad, Alzahrani, Azzah, Alhijji, Ibrahim A, Almomen, Abdulkareem, Aljefri, Abdullah, Al Saeed, Hussain H, Abdullah, Shaker, Al Rustumani, Ahmad, Mahour, Khoutir, Mousa, Shaker A
Format: Journal Article
Language:English
Published: England BioMed Central Ltd 17-09-2013
BioMed Central
Subjects:
Arabia - epidemiology
beta-Thalassemia - complications
beta-Thalassemia - diagnosis
beta-Thalassemia - epidemiology
Blood transfusion
Colleges & universities
Complications and side effects
Consensus
Defects
Disease
Disease prevention
Genes
Genetic disorders
Genotype & phenotype
Health sciences
Hospitals
Humans
Medical research
Medicine
Mutation
Pharmaceutical sciences
Population
Rare diseases
Review
Thalassemia
Arabia
Saudi Arabia
Persian Gulf region
Middle East
Southeast Asia
United States > US
Riyadh Saudi Arabia
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Description
Summary:Thalassemia syndrome has diverse clinical presentations and a global spread that has far exceeded the classical Mediterranean basin where the mutations arose. The mutations that give rise to either alpha or beta thalassemia are numerous, resulting in a wide spectrum of clinical severity ranging from carrier state to life-threatening, inherited hemolytic anemia that requires regular blood transfusion. Beta thalassemia major constitutes a remarkable challenge to health care providers. The complications arising due to the anemia, transfusional iron overload, as well as other therapy-related complications add to the complexity of this condition. To produce this consensus opinion manuscript, a PubMed search was performed to gather evidence-based original articles, review articles, as well as published work reflecting the experience of physicians and scientists in the Arabian Gulf region in an effort to standardize the management protocol.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1750-1172
1750-1172
DOI:10.1186/1750-1172-8-143