Search Results - "Mahoney, Sophia"

Aging, aerobic exercise, and cardiovascular health: Barriers, alternative strategies and future directions by Murray, Kevin O., Mahoney, Sophia A., Venkatasubramanian, Ravinandan, Seals, Douglas R., Clayton, Zachary S.

“…Age-associated cardiovascular (CV) dysfunction, namely arterial dysfunction, is a key antecedent to the development of CV disease (CVD). Arterial dysfunction…”
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Identification and functional analysis of senescent cells in the cardiovascular system using omics approaches by Mahoney, Sophia A, Dey, Amit K, Basisty, Nathan, Herman, Allison B

“…Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and senescent cells have emerged as key contributors to its pathogenesis…”
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Could angiotensin‐II induced T‐cell senescence exacerbate age‐related vascular dysfunction? by Venkatasubramanian, Ravinandan, Mahoney, Sophia A., Clayton, Zachary S.

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Socioeconomic status as a potential mediator of arterial aging in marginalized ethnic and racial groups: current understandings and future directions by Darvish, Sanna, Mahoney, Sophia A, Venkatasubramanian, Ravinandan, Rossman, Matthew J, Clayton, Zachary S, Murray, Kevin O

“…Cardiovascular diseases (CVDs) are the leading cause of death in the United States. However, disparities in CVD-related morbidity and mortality exist as…”
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Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment by Clayton, Zachary S, Rossman, Matthew J, Mahoney, Sophia A, Venkatasubramanian, Ravinandan, Maurer, Grace S, Hutton, David A, VanDongen, Nicholas S, Greenberg, Nathan T, Longtine, Abigail G, Ludwig, Katelyn R, Brunt, Vienna E, LaRocca, Thomas J, Campisi, Judith, Melov, Simon, Seals, Douglas R

“…Here, we assessed the role of cellular senescence and the senescence associated secretory phenotype (SASP) in age-related aortic stiffening and endothelial…”
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Fisetin Supplementation Improves Age‐Related Vascular Endothelial Function by Suppressing Cellular Senescence and Mitochondrial Oxidative Stress by Mahoney, Sophia A., Venkatasubramanian, Ravinandan, Rossman, Matthew, VanDongen, Nicholas, Brunt, Vienna, Casso, Abigail, Greenberg, Nathan, Melov, Simon, Campisi, Judith, Seals, Douglas, Clayton, Zachary

“…Age‐related vascular endothelial dysfunction is mediated by excess reactive oxygen species (ROS)—mitochondria (mito) being a key source—which can reduce nitric…”
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Intermittent supplementation with fisetin improves arterial function in old mice by decreasing cellular senescence by Mahoney, Sophia A., Venkatasubramanian, Ravinandan, Darrah, Mary A., Ludwig, Katelyn R., VanDongen, Nicholas S., Greenberg, Nathan T., Longtine, Abigail G., Hutton, David A., Brunt, Vienna E., Campisi, Judith, Melov, Simon, Seals, Douglas R., Rossman, Matthew J., Clayton, Zachary S.

“…Cellular senescence and the senescence‐associated secretory phenotype (SASP) contribute to age‐related arterial dysfunction, in part, by promoting oxidative…”
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Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach by Mahoney, Sophia A, VanDongen, Nicholas S, Greenberg, Nathan T, Venkatasubramanian, Ravinandan, Rossman, Matthew J, Widlansky, Michael E, Brunt, Vienna E, Bernaldo de Quirós, Yara, Seals, Douglas R, Clayton, Zachary S

“…The circulating milieu, bioactive molecules in the bloodstream, is altered with aging and interfaces constantly with the vasculature. This anatomic…”
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The bottlenose dolphin ( Tursiops truncatus ): a novel model for studying healthy arterial aging by Bernaldo de Quirós, Yara, Mahoney, Sophia A, VanDongen, Nicholas S, Greenberg, Nathan T, Venkatasubramanian, Ravinandan, Saavedra, Pedro, Bossart, Greg, Brunt, Vienna E, Clayton, Zachary S, Fernández, Antonio, Seals, Douglas R

“…Endothelial function declines with aging and independently predicts future cardiovascular disease (CVD) events. Diving also impairs endothelial function in…”
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WAT do you NO? Addressing obesity‐related cardiometabolic dysfunction by Mahoney, Sophia A., Ikoba, Akpevwe P., Rossman, Matthew J., Clayton, Zachary S.

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Female C57BL/6N mice are a viable model of aortic aging in women by Longtine, Abigail G, Venkatasubramanian, Ravinandan, Zigler, Melanie C, Lindquist, Alexandra J, Mahoney, Sophia A, Greenberg, Nathan T, VanDongen, Nicholas S, Ludwig, Katelyn R, Moreau, Kerrie L, Seals, Douglas R, Clayton, Zachary S

“…The aorta stiffens with aging in both men and women, which predicts cardiovascular mortality. Aortic wall structural and extracellular matrix (ECM) remodeling,…”
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Cellular Senescence and the Associated Secretome Contribute to Age‐Related Vascular Dysfunction by Venkatasubramanian, Ravinandan, Mahoney, Sophia A., Rossman, Matthew J., Hutton, David A., Brunt, Vienna E., VanDongen, Nicholas S., Casso, Abigail G., Greenberg, Nathan T., Quiros, Yara B., Melov, Simon, Campisi, Judith, Seals, Douglas R., Clayton, Zachary S.

“…Age‐related vascular dysfunction (e.g., large elastic artery [aorta] stiffening and endothelial dysfunction) is mediated by excess reactive oxygen species…”
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The influence of a human macronutrient-matched diet on phenotypes in old mice by Darrah, Mary A., Longtine, Abigail G., Greenberg, Nathan T., Mahoney, Sophia A., Venkatasubramanian, Ravinandan, VanDongen, Nicholas S., Reisz, Julie A., D’Alessandro, Angelo, Seals, Douglas R., de Quiros Miranda, Yara Bernaldo, Clayton, Zachary S.

“…Preclinical rodent models are essential research tools for improving understanding of physiological aging processes in humans. However, the translatability of…”
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Anthracycline chemotherapy‐mediated vascular dysfunction as a model of accelerated vascular aging by Clayton, Zachary S., Hutton, David A., Mahoney, Sophia A., Seals, Douglas R.

“…Cardiovascular diseases (CVD) are the leading cause of death worldwide, and age is by far the greatest risk factor for developing CVD. Vascular dysfunction,…”
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The short-chain fatty acid acetate improves age-associated vascular endothelial dysfunction by Greenberg, Nathan, Casso, Abigail, Lindquist, Alexandra, VanDongen, Nicholas, Mahoney, Sophia, Clayton, Zachary, Seals, Douglas, Brunt, Vienna

“…Abstract only Aging is the primary risk factor for cardiovascular diseases (CVD), the leading cause of death worldwide. Vascular endothelial dysfunction, a key…”
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Oral Supplementation with the Short-Chain Fatty Acid Acetate Ameliorates Age-Related Aortic Stiffening in Mice by Lindquist, Alexandra, Greenberg, Nathan, Longtine, Abigail, VanDongen, Nicholas, Mahoney, Sophia, Clayton, Zachary, Seals, Douglas, Brunt, Vienna

“…Abstract only Aging is the main risk factor for cardiovascular diseases (CVD) due in part to stiffening of large elastic arteries (e.g., aorta). High-fiber…”
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25-Hydroxycholesterol reduces aortic cellular senescence and stiffness in old mice by Mahoney, Sophia, Ciotlos, Serban, Darrah, Mary, Venkatasubramanian, Ravinandan, Rossman, Matthew, Campisi, Judith, Seals, Douglas, Melov, Simon, Clayton, Zachary

“…Abstract only Aortic stiffnessincreases with aging and is an independent risk factor for the development of cardiovascular diseases. Cellular senescence, a…”
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Circulating factors from old mice directly induce endothelial dysfunction and aortic stiffening in young mouse arteries: A novel ex vivo experimental approach by VanDongen, Nicholas, Mahoney, Sophia, Bernaldo de Quirós, Yara, Greenberg, Nathan, Hutton, David, Widlansky, Michael, Seals, Doulglas, Brunt, Vienna, Clayton, Zachary

“…Abstract only Aging is the primary risk factor for the development of cardiovascular diseases, largely as a result of reduced arterial function, characterized…”
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Cellular senescence mediates doxorubicin chemotherapy-induced aortic stiffening via circulating factors by Darrah, Mary, Venkatasubramanian, Ravinandan, Mahoney, Sophia, Ludwig, Katelyn, Hutton, David, Brunt, Vienna, Rossman, Matthew, Campisi, Judith, Seals, Douglas, Clayton, Zachary

“…Abstract only Introduction: The common chemotherapeutic agent doxorubicin (DOXO) mediates large elastic artery (aorta) stiffness in part via chronic low-grade…”
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Female C57Bl/6N mice are a viable model of human aortic aging: Aortic stiffness and structure and systemic inflammation by Longtine, Abigail, Venkatasubramanian, Ravinandan, Zigler, Melanie, Lindquist, Alexandra, Mahoney, Sophia, Greenberg, Nathan, VanDongen, Nicholas, Ludwig, Katelyn, Moreau, Kerrie, Seals, Douglas, Clayton, Zachary

“…Abstract only The aorta stiffens with aging in both men and women and predicts cardiovascular mortality. Stiffening occurs largely due to aortic wall…”
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