Search Results - "Mahoney, Emily R"

Brain expression of the vascular endothelial growth factor gene family in cognitive aging and alzheimer’s disease by Mahoney, Emily R., Dumitrescu, Logan, Moore, Annah M., Cambronero, Francis E., De Jager, Philip L., Koran, Mary Ellen I., Petyuk, Vladislav A., Robinson, Renã A. S., Goyal, Sandeep, Schneider, Julie A., Bennett, David A., Jefferson, Angela L., Hohman, Timothy J.

“…Vascular endothelial growth factor (VEGF) is associated with the clinical manifestation of Alzheimer’s disease (AD). However, the role of the VEGF gene family…”
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Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease by Raghavan, Neha S, Dumitrescu, Logan, Mormino, Elizabeth, Mahoney, Emily R, Lee, Annie J, Gao, Yizhe, Bilgel, Murat, Goldstein, David, Harrison, Theresa, Engelman, Corinne D, Saykin, Andrew J, Whelan, Christopher D, Liu, Jimmy Z, Jagust, William, Albert, Marilyn, Johnson, Sterling C, Yang, Hyun-Sik, Johnson, Keith, Aisen, Paul, Resnick, Susan M, Sperling, Reisa, De Jager, Philip L, Schneider, Julie, Bennett, David A, Schrag, Matthew, Vardarajan, Badri, Hohman, Timothy J, Mayeux, Richard

“…Genetic studies of Alzheimer disease have focused on the clinical or pathologic diagnosis as the primary outcome, but little is known about the genetic basis…”
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Inclusion of African American/Black adults in a pilot brain proteomics study of Alzheimer's disease by Stepler, Kaitlyn E., Mahoney, Emily R., Kofler, Julia, Hohman, Timothy J., Lopez, Oscar L., Robinson, Renã A.S.

“…Alzheimer's disease (AD) disproportionately affects certain racial and ethnic subgroups, such as African American/Black and Hispanic adults. Genetic, comorbid,…”
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Genetic variants and functional pathways associated with resilience to Alzheimer's disease by Dumitrescu, Logan, Mahoney, Emily R, Mukherjee, Shubhabrata, Lee, Michael L, Bush, William S, Engelman, Corinne D, Lu, Qiongshi, Fardo, David W, Trittschuh, Emily H, Mez, Jesse, Kaczorowski, Catherine, Hernandez Saucedo, Hector, Widaman, Keith F, Buckley, Rachel, Properzi, Michael, Mormino, Elizabeth, Yang, Hyun-Sik, Harrison, Tessa, Hedden, Trey, Nho, Kwangsik, Andrews, Shea J, Tommet, Doug, Hadad, Niran, Sanders, R Elizabeth, Ruderfer, Douglas M, Gifford, Katherine A, Moore, Annah M, Cambronero, Francis, Zhong, Xiaoyuan, Raghavan, Neha S, Vardarajan, Badri, Pericak-Vance, Margaret A, Farrer, Lindsay A, Wang, Li-San, Cruchaga, Carlos, Schellenberg, Gerard, Cox, Nancy J, Haines, Jonathan L, Keene, C Dirk, Saykin, Andrew J, Larson, Eric B, Sperling, Reisa A, Mayeux, Richard, Bennett, David A, Schneider, Julie A, Crane, Paul K, Jefferson, Angela L, Hohman, Timothy J

“…Approximately 30% of older adults exhibit the neuropathological features of Alzheimer's disease without signs of cognitive impairment. Yet, little is known…”
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Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease by Eissman, Jaclyn M, Dumitrescu, Logan, Mahoney, Emily R, Smith, Alexandra N, Mukherjee, Shubhabrata, Lee, Michael L, Scollard, Phoebe, Choi, Seo Eun, Bush, William S, Engelman, Corinne D, Lu, Qiongshi, Fardo, David W, Trittschuh, Emily H, Mez, Jesse, Kaczorowski, Catherine C, Hernandez Saucedo, Hector, Widaman, Keith F, Buckley, Rachel F, Properzi, Michael J, Mormino, Elizabeth C, Yang, Hyun Sik, Harrison, Theresa M, Hedden, Trey, Nho, Kwangsik, Andrews, Shea J, Tommet, Douglas, Hadad, Niran, Sanders, R Elizabeth, Ruderfer, Douglas M, Gifford, Katherine A, Zhong, Xiaoyuan, Raghavan, Neha S, Vardarajan, Badri N, Pericak-Vance, Margaret A, Farrer, Lindsay A, Wang, Li San, Cruchaga, Carlos, Schellenberg, Gerard D, Cox, Nancy J, Haines, Jonathan L, Keene, C Dirk, Saykin, Andrew J, Larson, Eric B, Sperling, Reisa A, Mayeux, Richard, Cuccaro, Michael L, Bennett, David A, Schneider, Julie A, Crane, Paul K, Jefferson, Angela L, Hohman, Timothy J

“…Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer's disease neuropathology at autopsy. Studying…”
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RNASE6 is a novel modifier of APOE-ε4 effects on cognition by Seto, Mabel, Weiner, Rebecca L., Dumitrescu, Logan, Mahoney, Emily R., Hansen, Shania L., Janve, Vaibhav, Khan, Omair A., Liu, Dandan, Wang, Yanling, Menon, Vilas, De Jager, Philip L., Schneider, Julie A., Bennett, David A., Gifford, Katherine A., Jefferson, Angela L., Hohman, Timothy J.

“…Apolipoprotein E4 (APOE-ε4), the strongest common genetic risk factor for Alzheimer's disease (AD), contributes to worse cognition in older adults. However,…”
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Multi-omic characterization of brain changes in the vascular endothelial growth factor family during aging and Alzheimer's disease by Seto, Mabel, Dumitrescu, Logan, Mahoney, Emily R., Sclafani, Annah M., De Jager, Philip L., Menon, Vilas, Koran, Mary E.I., Robinson, Renã A., Ruderfer, Douglas M., Cox, Nancy J., Seyfried, Nicholas T., Jefferson, Angela L., Schneider, Julie A., Bennett, David A., Petyuk, Vladislav A., Hohman, Timothy J.

“…•Vascular endothelial growth factor (VEGF) signaling is implicated in Alzheimer's disease.•The VEGF family exhibits differing effects across brain regions and…”
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Beyond Suction-Feeding Fishes: Identifying New Approaches to Performance Integration During Prey Capture in Aquatic Vertebrates by Kane, Emily A, Cohen, Hannah E, Hicks, William R, Mahoney, Emily R, Marshall, Christopher D

“…Abstract Organisms are composed of hierarchically arranged component parts that must work together to successfully achieve whole organism functions. In…”
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Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer’s Dementia by Ouellette, Andrew R., Neuner, Sarah M., Dumitrescu, Logan, Anderson, Laura C., Gatti, Daniel M., Mahoney, Emily R., Bubier, Jason A., Churchill, Gary, Peters, Luanne, Huentelman, Matthew J., Herskowitz, Jeremy H., Yang, Hyun-Sik, Smith, Alexandra N., Reitz, Christiane, Kunkle, Brian W., White, Charles C., De Jager, Philip L., Schneider, Julie A., Bennett, David A., Seyfried, Nicholas T., Chesler, Elissa J., Hadad, Niran, Hohman, Timothy J., Kaczorowski, Catherine C.

“…Genetic mechanisms underlying age-related cognitive decline and dementia remain poorly understood. Here, we take advantage of the Diversity Outbred mouse…”
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VEGF‐family brain protein abundance: Associations with Alzheimer’s disease pathology and cognitive decline by Hohman, Timothy J., Mahoney, Emily R., Dumitrescu, Logan, De Jager, Philip L, Koran, Mary Ellen I., Robinson, Renã AS, Ruderfer, Douglas M., Cox, Nancy J, Jefferson, Angela L., Schneider, Julie A., Bennett, David A., Petyuk, Vladislav A

“…Background Previous work has implicated associations between the angiogenic vascular endothelial growth factor (VEGF) gene family and Alzheimer’s disease (AD)…”
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Transcriptomic modifiers of the cognitive consequences of apolipoprotein E by Seto, Mabel, Dumitrescu, Logan, Mahoney, Emily R., Hansen, Shania L, Khan, Omair A., Liu, Dandan, De Jager, Philip L, Petyuk, Vladislav A, Schneider, Julie A., Bennett, David A., Gifford, Katherine A., Jefferson, Angela L., Hohman, Timothy J.

“…Background APOE‐ε4 is the strongest common genetic risk factor for Alzheimer’s disease (AD) and contributes to worse cognition. However, many carriers of the…”
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Sex differences in the genetic architecture underlying resilience in AD by Eissman, Jaclyn M., Dumitrescu, Logan, Mahoney, Emily R., Mukherjee, Shubhabrata, Lee, Michael L., Bush, William S., Engelman, Corinne D., Lu, Qiongshi, Fardo, David W., Trittschuh, Emily H., Mez, Jesse, Kaczorowski, Catherine C., Saucedo, Hector Hernandez, Widaman, Keith F., Buckley, Rachel F., Properzi, Michael J, Mormino, Elizabeth C., Yang, Hyun‐Sik, Harrison, Theresa M., Hedden, Trey, Nho, Kwangsik, Andrews, Shea J, Tommet, Douglas, Hadad, Niran, Sanders, R. Elizabeth, Ruderfer, Douglas M., Gifford, Katherine A., Zhong, Xiaoyuan, Raghavan, Neha S, Vardarajan, Badri N., Pericak‐Vance, Margaret A., Farrer, Lindsay A., Wang, Li‐San, Cruchaga, Carlos, Schellenberg, Gerard D., Cox, Nancy J, Haines, Jonathan L., Keene, C. Dirk, Saykin, Andrew J., Larson, Eric B., Sperling, Reisa A., Mayeux, Richard, Cuccaro, Michael L., Bennett, David A., Schneider, Julie A., Crane, Paul K., Jefferson, Angela L., Hohman, Timothy J.

“…Background Approximately 30% of older adults are cognitively normal at death despite presence of Alzheimer’s disease (AD) neuropathology at autopsy. Studying…”
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Telomere length associations with cognition depend on Alzheimer's disease biomarkers by Mahoney, Emily R., Dumitrescu, Logan, Seto, Mabel, Nudelman, Kelly N.H., Buckley, Rachel F., Gifford, Katie A., Saykin, Andrew J., Jefferson, Angela J., Hohman, Timothy J.

“…While telomere shortening, a marker of cellular aging, may impact the progression of age-related neurodegenerative diseases, its association with cognition is…”
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Sex‐specific genetic predictors of memory performance by Smith, Alexandra N., Dumitrescu, Logan, Mukherjee, Shubhabrata, Lee, Michael L., Choi, Seo‐Eun, Trittschuh, Emily H., Mez, Jesse, Mahoney, Emily R., Bush, William S., Engelman, Corinne D., Lu, Qiongshi, Fardo, David W., Widaman, Keith F., Buckley, Rachel F., Mormino, Elizabeth C., Harrison, Theresa M., Sanders, R. Elizabeth, Clark, Lindsay R., Gifford, Katherine A., Vardarajan, Badri N., Team, A4 Study, Cuccaro, Michael L., Pericak‐Vance, Margaret A., Farrer, Lindsay A., Wang, Li‐San, Schellenberg, Gerard D., Haines, Jonathan L., Jefferson, Angela L., Johnson, Sterling C., Kukull, Walter A., Albert, Marilyn S., Keene, C. Dirk, Saykin, Andrew J., Larson, Eric B., Sperling, Reisa A., Mayeux, Richard, Bennett, David A., Schneider, Julie A., Crane, Paul K., Hohman, Timothy J.

“…Background There are notable sex differences in the clinical manifestation of Alzheimer’s disease (AD), including differences in baseline and longitudinal…”
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Exploring common genetic contributors to neuroprotection from amyloid pathology by Seto, Mabel, Mahoney, Emily R., Dumitrescu, Logan, Ramanan, Vijay K., Engelman, Corinne D., Deming, Yuetiva, Albert, Marilyn, Johnson, Sterling C., Zetterberg, Henrik, Blennow, Kaj, Vemuri, Prashanthi, Jefferson, Angela L., Hohman, Timothy J.

“…Abstract Preclinical Alzheimer’s disease describes some individuals who harbour Alzheimer’s pathologies but are asymptomatic. For this study, we hypothesized…”
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Modular Synthesis of Peptide-Based Single- and Multimodal Targeted Molecular Imaging Agents by Schmitthenner, Hans F, Barrett, Taylor M, Beach, Stephanie A, Heese, Lauren E, Weidman, Chelsea, Dobson, Damien E, Mahoney, Emily R, Schug, Nicholas C, Jones, Kelsea G, Durmaz, Ceyda, Otasowie, Osarhuwense, Aronow, Sean, Lee, Yin Peng, Ophardt, Henry D, Becker, Amy E, Hornak, Joseph P, Evans, Irene M, Ferran, Maureen C

“…A practical, modular synthesis of targeted molecular imaging agents (TMIAs) containing near-infrared dyes for optical molecular imaging (OMI) or chelated…”
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Granulovacuolar degenerating body markers accumulate alongside dysfunctional lysosomes in dystrophic neurites and correlate with cognition in Alzheimer’s disease by Schrag, Matthew S, Mahoney, Emily R, Shostak, Alena, Nackenoff, Alex, Dumitrescu, Logan, Akers, Carolyn, Jefferson, Angela L, Hohman, Timothy J

“…Background Recent decades have brought a renaissance in understanding lysosomes and autophagy in neurobiology and neurodegenerative diseases. Neuronal…”
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Granulovacuolar degenerating body markers accumulate alongside dysfunctional lysosomes in dystrophic neurites and correlate with cognition in Alzheimer’s disease: Developing topics by Schrag, Matthew S, Mahoney, Emily R, Shostak, Alena, Nackenoff, Alex, Dumitrescu, Logan, Akers, Carolyn, Jefferson, Angela L, Hohman, Timothy J

“…Abstract Background Recent decades have brought a renaissance in understanding lysosomes and autophagy in neurobiology and neurodegenerative diseases. Neuronal…”
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CSF polygenic risk AD biomarkers predict brain amyloid and free recall by Kennedy, Gabriel, Moore, Annah M., Mahoney, Emily R., Dumitrescu, Logan, Sperling, Reisa A., Deming, Yuetiva, Cruchaga, Carlos, Hohman, Timothy J., Mormino, Elizabeth C.

“…Background The utility of aggregate measures of genetic risk such as polygenic risk scores (PRS) during the decades prior to actual disease onset of…”
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Exploring genetic contributors to neuroprotection from AD pathologies: A genome‐wide association study by Seto, Mabel, Mahoney, Emily R., Dumitrescu, Logan, Engelman, Corinne D., Deming, Yuetiva, Albert, Marilyn S., Johnson, Sterling C., Zetterberg, Henrik, Blennow, Kaj, Jefferson, Angela L., Hohman, Timothy J.

“…Background Preclinical Alzheimer’s disease (AD) is a term describing individuals who harbor neuropathological hallmarks of AD but are asymptomatic. We…”
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