A cross sectional study on antibiotic resistance pattern of Salmonella typhi clinical isolates from Bangladesh
Objective:To investigate and compare the resistance and sensitivity of Salmonella typhi samples to commonly used antibiotics in three major divisions of Bangladesh and to evaluate the gradually developing resistance pattern.Methods:The antibiotic susceptibility of 70 clinical isolates collected from...
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| Published in: | Asian Pacific journal of tropical biomedicine Vol. 4; no. 4; pp. 306 - 311 |
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| Main Authors: | , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
China
Elsevier B.V
01-04-2014
Asian Pacific Tropical Medicine Press Wolters Kluwer Medknow Publications |
| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Objective:To investigate and compare the resistance and sensitivity of Salmonella typhi samples to commonly used antibiotics in three major divisions of Bangladesh and to evaluate the gradually developing resistance pattern.Methods:The antibiotic susceptibility of 70 clinical isolates collected from blood,sputum,urine and pus samples were identified by specific antisera and with standard biochemical tests.The patients were divided into 5 age groups.Susceptibility and resistance was also tested by KirbyBauer disc-diffusion method using 12 regularly used antibiotics.Results:Antibiotic susceptibility test demonstrated that 64.28%isolates of Salmonella typhi were multidrug resistant.Present study suggests that the clinical samples were mostly resistant against nalidixic acid with all age groups and in all three divisions with similar resistance pattern.Resistance is more common among adult people(30-40 years)and children(0-10 years).Salmonella typhi was mostly sensitive against gentamycin,chloramphenicol and ciprofloxacin.Conclusions:Although the population density of Dhaka region is markedly higher than Rajshahi and Chittagong regions,no significant difference in resistance pattern was found.The rate of multidrug resistance is a matter of concern.Physicians should reconsider before prescribing nalidixic acid and cefixime.Further molecular study is needed to reveal the genomic and proteomic basis of resistance. |
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| Bibliography: | Adnan Mannan;Mohammad shohel;sultana Rajia;Niaz Uddin Mahmud;Sanjana Kabir;Imtiaj Hasan;Department of Genetic Engineering and Biotechnology,Faculty of Biological Sciences,University of Chittagong;Department of Pharmacy,North South University;Department of Pharmacy,Varendra University;Department of Computer Science & Engineering,BGC Trust University Bangladesh;Department of Biochemistry and Molecular Biology,Rajshahi University;Laboratory of Glycobiology and Marine Biochemistry,Department of Life and Environmental System Science,Graduate School of Nano Biosciences,Yokohama City University ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Comments: This is an interesting research work in which authors have demonstrated antibiotic resistance pattern of S. typhi clinical isolates in a highly populated developing country. The authos have showed that there is no relation between population density and evolving of resistant strains. Moreover, the authors have showed the overall resistant pattern of Salmonella typhi in population level, this information can be important for clinicians to provide treatment. Details on Page 310 |
| ISSN: | 2221-1691 2588-9222 |
| DOI: | 10.12980/APJTB.4.2014C770 |