First experience of Candida non-albicans isolates with high antibiotic resistance pattern caused oropharyngeal candidiasis among cancer patients

In cancer patients, Candida species can cause a variety of diseases particularly oropharyngeal candidiasis which is a common infection. In this study, an attempt has been made to determine susceptibility pattern of four antifungal agents against the Candida species isolated from cancer patients with...

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Bibliographic Details
Published in:	Journal of cancer research and therapeutics Vol. 11; no. 2; pp. 388 - 390
Main Authors:	Kalantar, Enayatollah, Marashi, Seyed Mahmoud Amin, Pormazaheri, Helen, Mahmoudi, Ellaheh, Hatami, Shiva, Barari, Maryam Agha, Naseh, Mohammad Hadi, Asadi, Mojan
Format:	Journal Article
Language:	English
Published:	India Medknow Publications and Media Pvt. Ltd 01-04-2015 Medknow Publications & Media Pvt. Ltd
Subjects:	Adolescent Adult Amphotericin B - therapeutic use Antibiotics Antifungal agents Antifungal Agents - therapeutic use Cancer Cancer patients Candida - drug effects Candida - isolation & purification Candidiasis Candidiasis, Oral - drug therapy Candidiasis, Oral - microbiology Care and treatment Causes of Deoxyribonucleic acid Diseases DNA Drug Resistance, Fungal Drug therapy Female Fungal infections Genes Health aspects Humans Ketoconazole - therapeutic use Male Microbial drug resistance Mortality Neoplasms - microbiology Polymerase chain reaction Prognosis Studies Young Adult United States Iran
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Summary:	In cancer patients, Candida species can cause a variety of diseases particularly oropharyngeal candidiasis which is a common infection. In this study, an attempt has been made to determine susceptibility pattern of four antifungal agents against the Candida species isolated from cancer patients with oropharyngeal candidiasis. Samples were taken from 50 cancer patients with oropharyngeal candidiasis by the physician, and isolation and identification of Candida spp. was done based on standard procedures. Antifungal resistance pattern was carried out according to CLSI guidelines, and 18s ribosomal RNA among Candida spp. was identified using multiplex polymerase chain reaction. Of the 50 patients, 18 (36%) were females and 32 (64%) were males; mean age was 38.4 years. Leukemia and lymphoma were the most frequent cancer types in the studied group, accounting for 17 (34%) and 12 (24%), respectively. A total of 29 Candida spp. were isolated from 29 cancer patients, of which 17 were C. albicans and 12 were C. non-albicans. All the Candida spp. were confirmed having 18s ribosomal RNA. Among all the Candida spp., C. non-albicans showed higher resistance pattern to amphotericin B (MIC 07 μg/ml) and ketoconazole (MIC = 05 μg/ml). In conclusion, oropharyngeal Candidiasis is a serious infection among cancer patients. The isolated Candida spp. were resistant to common antifungal agents, which may lead to longer hospital stay, more expensive/toxic drugs and higher mortality. Therefore, interval surveillance is necessary in developing institutional guidelines.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0973-1482 1998-4138
DOI:	10.4103/0973-1482.157307