Search Results - "Mahmoud Hashemi, Seyed"

Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options by Nazerian, Yasaman, Ghasemi, Mobina, Yassaghi, Younes, Nazerian, Amirhossein, Hashemi, Seyed Mahmoud

“…•Imbalance of RAAS system and hyper-activation of the Ang-II/AT1R axis promote hyper-inflammatory state and cytokine storm leading to end-organ…”
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Effect of mesenchymal stem cell‐derived exosomes on the induction of mouse tolerogenic dendritic cells by Shahir, Mehri, Mahmoud Hashemi, Seyed, Asadirad, Ali, Varahram, Mohammad, Kazempour‐Dizaji, Mehdi, Folkerts, Gert, Garssen, Johan, Adcock, Ian, Mortaz, Esmaeil

“…Dendritic cells (DCs) orchestrate innate inflammatory responses and adaptive immunity through T‐cell activation via direct cell–cell interactions and/or…”
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Immunomodulatory effects of mesenchymal stem cell–derived exosomes on experimental type‐1 autoimmune diabetes by Nojehdehi, Shahrzad, Soudi, Sara, Hesampour, Ardeshir, Rasouli, Shima, Soleimani, Masoud, Hashemi, Seyed Mahmoud

“…Exosomes derived from adipose tissue‐derived mesenchymal stem cells (AD‐MSCs) have immunomodulatory effects of T‐cell inflammatory response and reduction of…”
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Effects of Lipopolysaccharide from Porphyromonas gingivalis and Escherichia coli on Gene Expression Levels of Toll-like Receptors and Inflammatory Cytokines in Human Dental Pulp Stem Cells by Mojtahedi, Hanieh, Hossein-khannazer, Nikoo, Seyed Mahmoud Hashemi, Masoudnia, Mina, Askarzadeh, Monireh, Khojasteh, Arash, Sattari, Mandana

“…Background: Periodontal diseases originate from a group of oral inflammatory infections initiated by oral pathogens. Among these pathogens, Gram-negative…”
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Ethics of research on stem cells and regenerative medicine: ethical guidelines in the Islamic Republic of Iran by Afshar, Leila, Aghayan, Hamid-Reza, Sadighi, Jila, Arjmand, Babak, Hashemi, Seyed-Mahmoud, Basiri, Mohsen, Samani, Reza Omani, Ashtiani, Mohammad Kazemi, Azin, Seyed-Ali, Hajizadeh-Saffar, Ensiyeh, Gooshki, Ehsan Shamsi, Hamidieh, Amir-Ali, Rezania Moallem, Mohammad-Reza, Azin, Seyed-Mohammad, Shariatinasab, Sadegh, Soleymani-Goloujeh, Mehdi, Baharvand, Hossein

“…Regenerative medicine plays a major role in biomedicine, and given the ever-expanding boundaries of this knowledge, numerous ethical considerations have been…”
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Mesenchymal stem cell therapies for COVID-19: Current status and mechanism of action by Sadeghi, Somaye, Soudi, Sara, Shafiee, Abbas, Hashemi, Seyed Mahmoud

“…The outbreak of COVID-19 in December 2019, has become an urgent and serious public health emergency. At present, there is no effective treatment or vaccine for…”
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Exosome-mediated miR-33 transfer induces M1 polarization in mouse macrophages and exerts antitumor effect in 4T1 breast cancer cell line by Moradi-Chaleshtori, Maryam, Bandehpour, Mojgan, Heidari, Neda, Mohammadi-Yeganeh, Samira, Mahmoud Hashemi, Seyed

“…[Display omitted] •Exosomes can be used as an efficient nanocarrier for miR-33 delivery into macrophages.•miR-33 delivery into macrophages using exosomes…”
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Adipose‐derived mesenchymal stem cell‐secreted exosome alleviates dextran sulfate sodium‐induced acute colitis by Treg cell induction and inflammatory cytokine reduction by Heidari, Neda, Abbasi‐Kenarsari, Hajar, Namaki, Saeed, Baghaei, Kaveh, Zali, Mohammad Reza, Ghaffari Khaligh, Sahar, Hashemi, Seyed Mahmoud

“…Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is an inflammatory condition that results in gastrointestinal tract damage…”
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AS1411 aptamer-functionalized exosomes in the targeted delivery of doxorubicin in fighting colorectal cancer by Hosseini, Nashmin Fayazi, Amini, Razieh, Ramezani, Mohammad, Saidijam, Massoud, Hashemi, Seyed Mahmoud, Najafi, Rezvan

“…Severe side effects of chemotherapy agents on vital organs are the major causes of cancer-related mortality, not merely cancer disease. Encapsulating…”
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Effect of mesenchymal stem cells‐derived exosomes on tumor microenvironment: Tumor progression versus tumor suppression by Shojaei, Samaneh, Hashemi, Seyed Mahmoud, Ghanbarian, Hossein, Salehi, Mohammad, Mohammadi‐Yeganeh, Samira

“…Mesenchymal stem cells (MSCs) are multipotent cells with the potential to differentiate into different cell types. Owing to their immunosuppressive and…”
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CRISPR/Cas9-engineered mesenchymal stromal/stem cells and their extracellular vesicles: A new approach to overcoming cell therapy limitations by Hazrati, Ali, Malekpour, Kosar, Soudi, Sara, Hashemi, Seyed Mahmoud

“…Cell therapy is one of the newest therapeutic approaches for treating tissue destruction diseases and replacing damaged parts in defective tissues. Among…”
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Mesenchymal stromal/stem cells spheroid culture effect on the therapeutic efficacy of these cells and their exosomes: A new strategy to overcome cell therapy limitations by Hazrati, Ali, Malekpour, Kosar, Soudi, Sara, Hashemi, Seyed Mahmoud

“…Cell therapy is one of the new treatment methods in which mesenchymal stem/stromal cell (MSCs) transplantation is one of the cells widely used in this field…”
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Effect of Transplantation of Mesenchymal Stem Cells Induced into Early Hepatic Cells in Streptozotocin-Induced Diabetic Mice by Dinarvand, Peyman, Hashemi, Seyed Mahmoud, Soleimani, Masoud

“…Cellular replacement therapy for diabetes mellitus has received much attention. In this study we investigated the effect of transplantation of bone…”
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Exosomes as a novel cell‐free therapeutic approach in gastrointestinal diseases by Baghaei, Kaveh, Tokhanbigli, Samaneh, Asadzadeh, Hamid, Nmaki, Saeed, Reza Zali, Mohammad, Hashemi, Seyed Mahmoud

“…Cell communication through extracellular vesicles (EVs) has been defined for many years and it is not limited only to neighboring cells, but also distant ones…”
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Mesenchymal Stromal/Stem Cells and Their Extracellular Vesicles Application in Acute and Chronic Inflammatory Liver Diseases: Emphasizing on the Anti-Fibrotic and Immunomodulatory Mechanisms by Hazrati, Ali, Malekpour, Kosar, Soudi, Sara, Hashemi, Seyed Mahmoud

“…Various factors, including viral and bacterial infections, autoimmune responses, diabetes, drugs, alcohol abuse, and fat deposition, can damage liver tissue…”
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Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease by Sheykhhasan, Mohsen, Amini, Razieh, Soleimani Asl, Sara, Saidijam, Massoud, Hashemi, Seyed Mahmoud, Najafi, Rezvan

“…Alzheimer's disease (AD) is a degenerative disease that causes memory and learning impairments as well as dementia. Coenzyme Q10 (CoQ10) is an…”
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Human Wharton’s jelly mesenchymal stem cells derived-exosomes enriched by miR-124 promote an anti-fibrotic response in an experimental model of liver fibrosis by Niknam, Bahare, Baghaei, Kaveh, Mahmoud Hashemi, Seyed, Hatami, Behzad, Reza Zali, Mohammad, Amani, Davar

“…[Display omitted] •Exosomes reverses the Ly6Chi-dominant splenic monocyte phenotype in liver fibrosis.•ExomiR-124 suppresses HSCs activation by inhibition of…”
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Phenotypical and functional evaluation of dendritic cells after exosomal delivery of miRNA-155 by Asadirad, Ali, Hashemi, Seyed Mahmoud, Baghaei, Kaveh, Ghanbarian, Hossein, Mortaz, Esmaeil, Zali, Mohammad Reza, Amani, Davar

“…The clinical efficiency of dendritic cell (DC) therapy needs to be improved. Exosomes, as membrane nano-vesicles, carry bio-macromolecules and play essential…”
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In vitro and in vivo evaluation of anti-tumoral effect of M1 phenotype induction in macrophages by miR-130 and miR-33 containing exosomes by Moradi-Chaleshtori, Maryam, Bandehpour, Mojgan, Soudi, Sara, Mohammadi-Yeganeh, Samira, Hashemi, Seyed Mahmoud

“…In the tumor microenvironment, macrophages polarize into the M2 phenotype to facilitate tumorigenesis. Tumor-derived exosomes can act as mediators between the…”
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Study of the immunomodulatory effects of osteogenic differentiated human dental pulp stem cells by Hossein-khannazer, Nikoo, Hashemi, Seyed Mahmoud, Namaki, Saeed, Ghanbarian, Hossein, Sattari, Mandana, Khojasteh, Arash

“…Dental pulp stem cells (DPSC) are promising tools in regenerative medicine due to their differentiation potential and immunomodulatory properties. However, it…”
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