Search Results - "Mahmoud, Ramy"

The Speech of Fate in the Time of the Corona by MAHMOUD, Ramy

“…The Coronavirus pandemic has been ongoing for almost two years now. Not only did it surprise the whole world in the initial stages of its occurrence, but also…”
Get full text

THE DEFINITION OF THE SUNNAH ACCORDING TO ISMAILISM: A CRITICAL READING by Mahmoud, Ramy

“…This research discusses the understanding of the sunnah according to Ismailism. The understanding of the Sunnah has been dominated by the definition of sunnah…”
Get full text

The nasal approach to delivering treatment for brain diseases: an anatomic, physiologic, and delivery technology overview by Djupesland, Per G, Messina, John C, Mahmoud, Ramy A

“…The intricate pathophysiology of brain disorders, difficult access to the brain, and the complexity and high risks and costs of drug development represent…”
Get more information

NAVIGATE II: Randomized, double-blind trial of the exhalation delivery system with fluticasone for nasal polyposis by Leopold, Donald A., Elkayam, David, Messina, John C., Kosik-Gonzalez, Colette, Djupesland, Per G., Mahmoud, Ramy A.

“…Chronic rhinosinusitis is common and sometimes complicated by nasal polyps (NPs). Corticosteroid nasal sprays are often unsatisfactory because they are…”
Get full text

Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial by Quintana, Daniel S, Westlye, Lars T, Alnæs, Dag, Rustan, Øyvind G, Kaufmann, Tobias, Smerud, Knut T, Mahmoud, Ramy A, Djupesland, Per G, Andreassen, Ole A

“…Highlights • 8IU intranasal oxytocin (OT) treatment dampens amygdala activation in response to emotional faces. • Intravenous OT treatment did not produce…”
Get full text

Anticholinergic Activity of 107 Medications Commonly Used by Older Adults by Chew, Marci L., Mulsant, Benoit H., Pollock, Bruce G., Lehman, Mark E., Greenspan, Andrew, Mahmoud, Ramy A., Kirshner, Margaret A., Sorisio, Denise A., Bies, Robert R., Gharabawi, Georges

“…The objective of this study was to measure the anticholinergic activity (AA) of medications commonly used by older adults. A radioreceptor assay was used to…”
Get full text

NAVIGATE I: Randomized, Placebo-Controlled, Double-Blind Trial of the Exhalation Delivery System With Fluticasone for Chronic Rhinosinusitis With Nasal Polyps by Sindwani, Raj, Han, Joseph K., Soteres, Daniel F., Messina, John C., Carothers, Jennifer L., Mahmoud, Ramy A., Djupesland, Per G.

“…Background Chronic rhinosinusitis is a common, high-morbidity chronic inflammatory disease, and patients often experience suboptimal outcomes with current…”
Get full text

A Randomized Comparison of the Pharmacokinetics and Bioavailability of Fluticasone Propionate Delivered via Xhance Exhalation Delivery System Versus Flonase Nasal Spray and Flovent HFA Inhalational Aerosol by Messina, John C., Offman, Elliot, Carothers, Jennifer L., Mahmoud, Ramy A.

“…The exhalation delivery system with fluticasone propionate (Xhance®) has been shown to deliver drug substantially more broadly in the nasal cavity…”
Get full text

A cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis by Palmer, James N, Messina, John C, Biletch, Robert, Grosel, Kirk, Mahmoud, Ramy A

“…Chronic rhinosinusitis (CRS) is believed to create a substantial population-level disease burden in the United States due to its high prevalence and…”
Get more information

Hypothetical case replacement can be used to quantify the robustness of trial results by Frank, Kenneth A., Lin, Qinyun, Maroulis, Spiro, Mueller, Anna S., Xu, Ran, Rosenberg, Joshua M., Hayter, Christopher S., Mahmoud, Ramy A., Kolak, Marynia, Dietz, Thomas, Zhang, Lixin

“…•We introduce a case replacement framework for sensitivity analysis of clinical trials.•The framework supports statements such as “The inference would change…”
Get full text

Role of nasal casts for in vitro evaluation of nasal drug delivery and quantitative evaluation of various nasal casts by Djupesland, Per G, Messina, John C, Mahmoud, Ramy A

“…Nasal casts may characterize intranasal drug deposition. The Koken cast, described as 'anatomically correct', and the Optinose cast, derived from MRI of a…”
Get full text

Low-dose intranasal oxytocin delivered with Breath Powered device modulates pupil diameter and amygdala activity: a randomized controlled pupillometry and fMRI study by Quintana, Daniel S, Westlye, Lars T, Alnæs, Dag, Kaufmann, Tobias, Mahmoud, Ramy A, Smerud, Knut T, Djupesland, Per G, Andreassen, Ole A

“…Little is known about how intranasally administered oxytocin reaches the brain and modulates social behavior and cognition. Pupil dilation is a sensitive index…”
Get full text

Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men by Quintana, Daniel S., Westlye, Lars T., Smerud, Knut T., Mahmoud, Ramy A., Andreassen, Ole A., Djupesland, Per G.

“…Oxytocin plays an important role in social behavior. Thus, there has been significant research interest for the role of the oxytocin system in several…”
Get full text

Response to “three comments on the RIR method” by Frank, Kenneth A., Lin, Qinyun, Maroulis, Spiro, Mueller, Anna S., Xu, Ran, Rosenberg, Joshua M., Hayter, Christopher S., Mahmoud, Ramy A., Kolak, Marynia, Dietz, Thomas, Zhang, Lixin

“…Because counterfactual data can never be observed, we can never be certain of an effect of a treatment on an individual. [...]in practice we aggregate…”
Get full text

Improved Pharmacokinetics of Sumatriptan With Breath Powered™ Nasal Delivery of Sumatriptan Powder by Obaidi, Mohammad, Offman, Elliot, Messina, John, Carothers, Jennifer, Djupesland, Per G., Mahmoud, Ramy A.

“…Objectives.— The purpose of this study was to directly compare the pharmacokinetic (PK) profile of 22‐mg sumatriptan powder delivered intranasally with a novel…”
Get full text

Breath Powered Nasal Delivery: A New Route to Rapid Headache Relief by Djupesland, Per G., Messina, John C., Mahmoud, Ramy A.

“…The nose offers an attractive noninvasive alternative for drug delivery. Nasal anatomy, with a large mucosal surface area and high vascularity, allows for…”
Get full text

AVP-825 Breath-Powered Intranasal Delivery System Containing 22 mg Sumatriptan Powder vs 100 mg Oral Sumatriptan in the Acute Treatment of Migraines (The COMPASS Study): A Comparative Randomized Clinical Trial Across Multiple Attacks by Tepper, Stewart J., Cady, Roger K., Silberstein, Stephen, Messina, John, Mahmoud, Ramy A., Djupesland, Per G., Shin, Paul, Siffert, Joao

“…Objective The objective of this study was to compare the efficacy, tolerability, and safety of AVP‐825, an investigational bi‐directional breath‐powered…”
Get full text

Exhalation Delivery Systems (EDS) Greatly Increase Topical Delivery to Target Sites for Chronic Rhinosinusitis (CRS) Compared to Nasal Sprays or Pressurized MDIs (pMDI) by Djupesland, Per G., Messina, John C., Mahmoud, Ramy A.

“…Rationale Labyrithine nasal passages, the narrow nasal valve and complex static and dynamic aerodynamics limit traditional intranasal steroids’ (INS) ability…”
Get full text

Accessing the Brain: The Nose may Know the Way by Djupesland, Per G, Mahmoud, Ramy A, Messina, John C

Get full text

AVP-825 Breath-Powered Intranasal Delivery System Containing 22mg Sumatriptan Powder vs 100mg Oral Sumatriptan in the Acute Treatment of Migraines (The COMPASS Study): A Comparative Randomized Clinical Trial Across Multiple Attacks by Tepper, Stewart J, Cady, Roger K, Silberstein, Stephen, Messina, John, Mahmoud, Ramy A, Djupesland, Per G, Shin, Paul, Siffert, Joao

“…Objective The objective of this study was to compare the efficacy, tolerability, and safety of AVP-825, an investigational bi-directional breath-powered…”
Get full text