COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies

COVID-19-Associated Candidiasis: Possible Patho-Mechanism, Predisposing Factors, and Prevention Strategies

The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening public health. A large number of affected people need to be hospitalized. Immunocompromised patients and ICU-admitted patients are predisposed to further bacterial and fung...

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Bibliographic Details
Published in:Current microbiology Vol. 79; no. 5; p. 127
Main Authors: Ahmed, Nafisa, Mahmood, Maiesha Samiha, Ullah, Md. Asad, Araf, Yusha, Rahaman, Tanjim Ishraq, Moin, Abu Tayab, Hosen, Mohammad Jakir
Format: Journal Article
Language:English
Published: New York Springer US 01-05-2022
Springer Nature B.V
Subjects:
Biomedical and Life Sciences
Biotechnology
Candida - genetics
Candidiasis
Causality
Complications
Coronaviruses
COVID-19
Humans
Immune system
Immunocompromised hosts
Life Sciences
Microbiology
Nosocomial infection
Pathogenesis
Prevention
Public health
Review
Review Article
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Viral diseases
Virulence
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Summary:The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is threatening public health. A large number of affected people need to be hospitalized. Immunocompromised patients and ICU-admitted patients are predisposed to further bacterial and fungal infections, making patient outcomes more critical. Among them, COVID-19-associated candidiasis is becoming more widely recognized as a part of severe COVID-19 sequelae. While the molecular pathophysiology is not fully understood, some factors, including a compromised immune system, iron and zinc deficiencies, and nosocomial and iatrogenic transmissions, predispose COVID-19 patients to candidiasis. In this review, we discuss the existing knowledge of the virulence characteristics of Candida spp. and summarize the key concepts in the possible molecular pathogenesis. We analyze the predisposing factors that make COVID-19 patients more susceptible to candidiasis and the preventive measures which will provide valuable insights to guide the effective prevention of candidiasis in COVID-19 patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-022-02824-6