Search Results - "Mahlin, Denny"

The Need for Restructuring the Disordered Science of Amorphous Drug Formulations by Edueng, Khadijah, Mahlin, Denny, Bergström, Christel A. S.

“…The alarming numbers of poorly soluble discovery compounds have centered the efforts towards finding strategies to improve the solubility. One of the…”
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Physical stability of drugs after storage above and below the glass transition temperature: Relationship to glass-forming ability by Alhalaweh, Amjad, Alzghoul, Ahmad, Mahlin, Denny, Bergström, Christel A.S.

“…[Display omitted] Amorphous materials are inherently unstable and tend to crystallize upon storage. In this study, we investigated the extent to which the…”
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Early drug development predictions of glass-forming ability and physical stability of drugs by Mahlin, Denny, Bergström, Christel A.S.

“…The purpose of this study was to investigate if rapidly measured physical properties can predict glass-forming ability and glass stability of drug compounds. A…”
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Computational Predictions of Glass-Forming Ability and Crystallization Tendency of Drug Molecules by Alhalaweh, Amjad, Alzghoul, Ahmad, Kaialy, Waseem, Mahlin, Denny, Bergström, Christel A. S

“…Amorphization is an attractive formulation technique for drugs suffering from poor aqueous solubility as a result of their high lattice energy. Computational…”
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Supersaturation Potential of Amorphous Active Pharmaceutical Ingredients after Long-Term Storage by Edueng, Khadijah, Mahlin, Denny, Gråsjö, Johan, Nylander, Olivia, Thakrani, Manish, Bergström, Christel A S

“…This study explores the effect of physical aging and/or crystallization on the supersaturation potential and crystallization kinetics of amorphous active…”
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Long-Term Physical (In)Stability of Spray-Dried Amorphous Drugs: Relationship with Glass-Forming Ability and Physicochemical Properties by Edueng, Khadijah, Bergström, Christel A S, Gråsjö, Johan, Mahlin, Denny

“…This study shows the importance of the chosen method for assessing the glass-forming ability (GFA) and glass stability (GS) of a drug compound. Traditionally,…”
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Toward In Silico Prediction of Glass-Forming Ability from Molecular Structure Alone: A Screening Tool in Early Drug Development by Mahlin, Denny, Ponnambalam, Sopana, Heidarian Höckerfelt, Mina, Bergström, Christel A. S

“…We present a novel computational tool which predicts the glass-forming ability of drug compounds solely from their molecular structure. Compounds which show…”
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Effect of Surface Energy on Powder Compactibility by Fichtner, Frauke, Mahlin, Denny, Welch, Ken, Gaisford, Simon, Alderborn, Göran

“…Purpose The influence of surface energy on the compactibility of lactose particles has been investigated. Materials and Methods Three powders were prepared by…”
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Confinement of Amorphous Lactose in Pores Formed Upon Co-Spray Drying With Nanoparticles by Hellrup, Joel, Mahlin, Denny

“…This study aims at investigating factors influencing humidity-induced recrystallization of amorphous lactose, produced by co-spray drying with particles of…”
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Exploring vacuum foam drying as an alternative to freeze-drying and spray drying for a human lipase by Osanlóo, Daniel Tristan, Mahlin, Denny, Bjerregaard, Simon, Bergenståhl, Björn, Millqvist-Fureby, Anna

“…[Display omitted] This article compares and explores vacuum foam-drying as an alternative drying technology to freeze-drying and spray drying for a recombinant…”
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Formulation factors affecting foam properties during vacuum foam-drying by Tristan Osanlóo, Daniel, Mahlin, Denny, Bjerregaard, Simon, Bergenståhl, Björn, Millqvist-Fureby, Anna

“…[Display omitted] This paper explores how vacuum foam-drying of a protein is influenced by formulation parameters by investigating the foam structure, physical…”
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Pharmaceutical micro-particles give amorphous sucrose higher physical stability by Hellrup, Joel, Mahlin, Denny

“…Freeze-dried composites of sucrose and micro-sized filler particles show higher physical stability than neat freeze-dried sucrose. The aim of this study was to…”
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Mechanism-based selection of stabilization strategy for amorphous formulations: Insights into crystallization pathways by Edueng, Khadijah, Mahlin, Denny, Larsson, Per, Bergström, Christel A.S.

“…We developed a step-by-step experimental protocol using differential scanning calorimetry (DSC), dynamic vapour sorption (DVS), polarized light microscopy…”
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Production and characterization of aluminium oxide nanoshells on spray dried lactose by Hellrup, Joel, Rooth, Mårten, Johansson, Anders, Mahlin, Denny

“…[Display omitted] Atomic layer deposition (ALD) enables deposition of dense nanometer thick metal oxide nanoshells on powder particles with precise thickness…”
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Structural effects caused by spray- and freeze-drying of liposomes and bilayer disks by Wessman, Per, Edwards, Katarina, Mahlin, Denny

“…Cryo-TEM and dynamic light scattering was used to investigate morphological changes induced by spray- and freeze-drying of liposomes and nanosized bilayer…”
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Pharmaceutical profiling and molecular dynamics simulations reveal crystallization effects in amorphous formulations by Edueng, Khadijah, Kabedev, Aleksei, Ekdahl, Alyssa, Mahlin, Denny, Baumann, John, Mudie, Deanna, Bergström, Christel A.S.

“…[Display omitted] Robust and reliable in vivo performance of medicines based on amorphous solid dispersions (ASDs) depend on maintenance of physical stability…”
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Powder compression mechanics of spray-dried lactose nanocomposites by Hellrup, Joel, Nordström, Josefina, Mahlin, Denny

“…[Display omitted] The aim of this study was to investigate the structural impact of the nanofiller incorporation on the powder compression mechanics of…”
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Inhibition of Recrystallization of Amorphous Lactose in Nanocomposites Formed by Spray-Drying by Hellrup, Joel, Alderborn, Göran, Mahlin, Denny

“…This study aims at investigating the recrystallization of amorphous lactose in nanocomposites. In particular, the focus is on the influence of the nano- to…”
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Structure and Mobility of Lactose in Lactose/Sodium Montmorillonite Nanocomposites by Hellrup, Joel, Holmboe, Michael, Nartowski, Karol P, Khimyak, Yaroslav Z, Mahlin, Denny

“…This study aims at investigating the molecular level organization and molecular mobility in montmorillonite nanocomposites with the uncharged organic…”
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Experimental and Computational Prediction of Glass Transition Temperature of Drugs by Alzghoul, Ahmad, Alhalaweh, Amjad, Mahlin, Denny, Bergström, Christel A. S

“…Glass transition temperature (T g) is an important inherent property of an amorphous solid material which is usually determined experimentally. In this study,…”
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