Search Results - "Mahler, Stephen"

CNO Evil? Considerations for the Use of DREADDs in Behavioral Neuroscience by Mahler, Stephen V, Aston-Jones, Gary

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Phage Display Derived Monoclonal Antibodies: From Bench to Bedside by Alfaleh, Mohamed A, Alsaab, Hashem O, Mahmoud, Ahmad Bakur, Alkayyal, Almohanad A, Jones, Martina L, Mahler, Stephen M, Hashem, Anwar M

“…Monoclonal antibodies (mAbs) have become one of the most important classes of biopharmaceutical products, and they continue to dominate the universe of…”
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Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms by Farrell, Mitchell R., Schoch, Hannah, Mahler, Stephen V.

“…Addiction is a chronic relapsing disorder, in that most addicted individuals who choose to quit taking drugs fail to maintain abstinence in the long-term…”
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High-potency ligands for DREADD imaging and activation in rodents and monkeys by Bonaventura, Jordi, Eldridge, Mark A. G., Hu, Feng, Gomez, Juan L., Sanchez-Soto, Marta, Abramyan, Ara M., Lam, Sherry, Boehm, Matthew A., Ruiz, Christina, Farrell, Mitchell R., Moreno, Andrea, Galal Faress, Islam Mustafa, Andersen, Niels, Lin, John Y., Moaddel, Ruin, Morris, Patrick J., Shi, Lei, Sibley, David R., Mahler, Stephen V., Nabavi, Sadegh, Pomper, Martin G., Bonci, Antonello, Horti, Andrew G., Richmond, Barry J., Michaelides, Michael

“…Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are a popular chemogenetic technology for manipulation of neuronal activity in…”
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Neurodevelopmental origins of substance use disorders: Evidence from animal models of early‐life adversity and addiction by Levis, Sophia C., Baram, Tallie Z., Mahler, Stephen V., Schmidt, Mathias

“…Addiction is a chronic relapsing disorder with devastating personal, societal, and economic consequences. In humans, early‐life adversity (ELA) such as trauma,…”
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Motivational activation: a unifying hypothesis of orexin/hypocretin function by Mahler, Stephen V, Moorman, David E, Smith, Rachel J, James, Morgan H, Aston-Jones, Gary

“…Orexins (hypocretins) are involved in a large variety of behaviors and physiological processes including feeding, sleep/wake regulation, and reward. In this…”
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Prefrontal Pathways Provide Top-Down Control of Memory for Sequences of Events by Jayachandran, Maanasa, Linley, Stephanie B., Schlecht, Maximilian, Mahler, Stephen V., Vertes, Robert P., Allen, Timothy A.

“…We remember our lives as sequences of events, but it is unclear how these memories are controlled during retrieval. In rats, the medial prefrontal cortex…”
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DREADDs: Use and Application in Behavioral Neuroscience by Smith, Kyle S, Bucci, David J, Luikart, Bryan W, Mahler, Stephen V

“…Technological advances over the last decade are changing the face of behavioral neuroscience research. Here we review recent work on the use of one such…”
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Prelimbic to Accumbens Core Pathway Is Recruited in a Dopamine-Dependent Manner to Drive Cued Reinstatement of Cocaine Seeking by McGlinchey, Ellen M, James, Morgan H, Mahler, Stephen V, Pantazis, Caroline, Aston-Jones, Gary

“…Glutamate inputs to nucleus accumbens (NAc) facilitate conditioned drug-seeking behavior and primarily originate from medial prefrontal cortex (mPFC),…”
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On the early life origins of vulnerability to opioid addiction by Levis, Sophia C., Bentzley, Brandon S., Molet, Jenny, Bolton, Jessica L., Perrone, Christina R., Baram, Tallie Z., Mahler, Stephen V.

“…The origins and neural bases of the current opioid addiction epidemic are unclear. Genetics plays a major role in addiction vulnerability, but cannot account…”
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DREADDs: Use and Application in Behavioral Neuroscience by Smith, Kyle S., Bucci, David J., Luikart, Bryan W., Mahler, Stephen V.

“…Technological advances over the last decade are changing the face of behavioral neuroscience research. Here we review recent work on the use of one such…”
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What and when to “want”? Amygdala-based focusing of incentive salience upon sugar and sex by Mahler, Stephen V., Berridge, Kent C.

“…Rationale Amygdala-related circuitry helps translate learned Pavlovian associations into appetitive and aversive motivation, especially upon subsequent…”
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Designer receptors show role for ventral pallidum input to ventral tegmental area in cocaine seeking by Mahler, Stephen V, Vazey, Elena M, Beckley, Jacob T, Keistler, Colby R, McGlinchey, Ellen M, Kaufling, Jennifer, Wilson, Steven P, Deisseroth, Karl, Woodward, John J, Aston-Jones, Gary

“…The authors show that rostral ventral pallidum projections to the ventral tegmental area (VTA) are activated during cue-induced reinstatement of cocaine…”
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Author Correction: Stay alert, don’t get hurt by Mahler, Stephen V.

“…In the version of this article initially published, paragraph 8 mentioned intra-accumbens administration of SB334867. This should have read systemic…”
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Stay alert, don’t get hurt by Mahler, Stephen V.

“…Both nucleus accumbens and orexin play clear roles in motivated behavior, but the functions of orexin projections to accumbens are poorly understood. Blomeley…”
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Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats by Mahler, Stephen V, Aston-Jones, Gary S

“…Ventral tegmental area (VTA) dopamine neurons are crucial for appetitive responses to Pavlovian cues, including cue-induced reinstatement of drug seeking…”
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Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats by Mahler, Stephen V., Smith, Rachel J., Aston-Jones, Gary

“…Rationale Glutamate and orexin/hypocretin systems are involved in Pavlovian cue-triggered drug seeking. Objectives Here, we asked whether orexin and glutamate…”
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A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition by Lawson, Kate A., Ruiz, Christina M., Mahler, Stephen V.

“…Rationale Designer receptors exclusively activated by designer drugs (DREADDs) are a tool for “remote control” of defined neuronal populations during behavior…”
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Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice by Birnie, Matthew T., Short, Annabel K., de Carvalho, Gregory B., Taniguchi, Lara, Gunn, Benjamin G., Pham, Aidan L., Itoga, Christy A., Xu, Xiangmin, Chen, Lulu Y., Mahler, Stephen V., Chen, Yuncai, Baram, Tallie Z.

“…Disrupted operations of the reward circuit underlie major emotional disorders, including depression, which commonly arise following early life stress /…”
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A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? by James, Morgan H, Mahler, Stephen V, Moorman, David E, Aston-Jones, Gary

“…One decade ago, our laboratory provided the first direct evidence linking orexin/hypocretin signaling with drug seeking by showing that activation of these…”
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