Search Results - "Mahle, D.A."

A Species Comparison of Chloral Hydrate Metabolism in Blood and Liver by Lipscomb, J.C., Mahle, D.A., Brashear, W.T., Garrett, C.M.

“…Chloral hydrate (CH), [302-17-0], is a human sedative useful in premature infants. No current epidemiological study supports increased cancer risk. CH is also…”
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Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo by Andersen, M E, Clewell, 3rd, H J, Mahle, D A, Gearhart, J M

“…In common with a diverse group of low-molecular-weight volatile substrates, dichloromethane (DCM; methylene chloride) is a high-affinity, low-capacity…”
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Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE) by Gearhart, J M, Mahle, D A, Greene, R J, Seckel, C S, Flemming, C D, Fisher, J W, Clewell, 3rd, H J

“…When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate…”
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