Search Results - "Mahle, D A"

Dichloroacetic acid: metabolism in cytosol by Lipscomb, J C, Mahle, D A, Brashear, W T, Barton, H A

“…Dichloroacetic acid (DCA) arises from the chlorination of drinking water and the metabolism of trichloroethylene (TRI) and is used therapeutically. The…”
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Variability of physiologically based pharmacokinetic (PBPK) model parameters and their effects on PBPK model predictions in a risk assessment for perchloroethylene (PCE) by Gearhart, J M, Mahle, D A, Greene, R J, Seckel, C S, Flemming, C D, Fisher, J W, Clewell, 3rd, H J

“…When used in the risk assessment process, the output from physiologically based pharmacokinetic (PBPK) models has usually been considered as an exact estimate…”
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Predicting Age-Appropriate Pharmacokinetics of Six Volatile Organic Compounds in the Rat Utilizing Physiologically Based Pharmacokinetic Modeling by Rodriguez, Chester E., Mahle, Deirdre A., Gearhart, Jeff M., Mattie, David R., Lipscomb, John C., Cook, Robert S., Barton, Hugh A.

“…The capability of physiologically based pharmacokinetic models to incorporate age-appropriate physiological and chemical-specific parameters was utilized to…”
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In Vivo Kinetics of Trichloroacetate in Male Fischer 344 Rats by Yu, Kyung O., Barton, Hugh A., Mahle, Deirdre A., Frazier, John M.

“…Trichloroacetate (TCA) is a toxicologically important metabolite of the industrial solvents trichloroethylene and tetrachloroethylene, and a by-product of the…”
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A Species Comparison of Chloral Hydrate Metabolism in Blood and Liver by Lipscomb, J.C., Mahle, D.A., Brashear, W.T., Garrett, C.M.

“…Chloral hydrate (CH), [302-17-0], is a human sedative useful in premature infants. No current epidemiological study supports increased cancer risk. CH is also…”
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Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo by Andersen, M E, Clewell, 3rd, H J, Mahle, D A, Gearhart, J M

“…In common with a diverse group of low-molecular-weight volatile substrates, dichloromethane (DCM; methylene chloride) is a high-affinity, low-capacity…”
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Predicting Neonatal Perchlorate Dose and Inhibition of Iodide Uptake in the Rat during Lactation Using Physiologically-Based Pharmacokinetic Modeling by Clewell, Rebecca A., Merrill, Elaine A., Yu, Kyung O., Mahle, Deirdre A., Sterner, Teresa R., Fisher, Jeffrey W., Gearhart, Jeffery M.

“…Perchlorate (ClO4−), a contaminant in drinking water, competitively inhibits active uptake of iodide (I−) into various tissues, including mammary tissue…”
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Structural determination of the carboxylic acid metabolites of polychlorotrifluoroethylene by Brashear, W T, Greene, R J, Mahle, D A

“…1. Polychlorotrifluoroethylene (PCTFE) is a perhalogenated hydrocarbon which consists mainly of C-6 and C-8 oligomers of chlorotrifluoroethylene (CTFE)…”
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A partition coefficient determination method for nonvolatile chemicals in biological tissues by Jepson, G W, Hoover, D K, Black, R K, McCafferty, J D, Mahle, D A, Gearhart, J M

“…Partition or distribution coefficients are critical elements in efforts designed to describe the uptake, distribution, biotransformation, and excretion of…”
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The Pharmacokinetics of Perchlorate and Its Effect on the Hypothalamus–Pituitary–Thyroid Axis in the Male Rat by Yu, Kyung O., Narayanan, Latha, Mattie, David R., Godfrey, Richard J., Todd, Paula N., Sterner, Teresa R., Mahle, Deirdre A., Lumpkin, Michael H., Fisher, Jeffrey W.

“…Perchlorate, an environmental contaminant, is known to disturb the hypothalamus–pituitary–thyroid (HPT) axis by blocking iodide accumulation in the thyroid…”
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Predicting Fetal Perchlorate Dose and Inhibition of Iodide Kinetics during Gestation: A Physiologically-Based Pharmacokinetic Analysis of Perchlorate and Iodide Kinetics in the Rat by Clewell, Rebecca A., Merrill, Elaine A., Yu, Kyung O., Mahle, Deirdre A., Sterner, Teresa R., Mattie, David R., Robinson, Peter J., Fisher, Jeffrey W., Gearhart, Jeffery M.

“…Perchlorate (ClO4−) disrupts endocrine homeostasis by competitively inhibiting the transport of iodide (I−) into the thyroid. The potential for health effects…”
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Age-Dependent Partition Coefficients for a Mixture of Volatile Organic Solvents in Sprague-Dawley Rats and Humans by Mahle, Deirdre A., Gearhart, Jeffery M., Grigsby, Claude C., Mattie, David R., Barton, Hugh A., Lipscomb, John C., Cook, Robert S.

“…The absorption, distribution, metabolism, and excretion of volatile organic compounds (VOCs) are critically determined by a few chemical-specific factors,…”
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A Quantitative Description of Suicide Inhibition of Dichloroacetic Acid in Rats and Mice by Keys, Deborah A., Schultz, Irvin R., Mahle, Deirdre A., Fisher, Jeffrey W.

“…Dichloroacetic acid (DCA), a minor metabolite of trichloroethylene (TCE) and water disinfection byproduct, remains an important risk assessment issue because…”
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Changes in Cross-Fostered Sprague-Dawley Rat Litters Exposed to Perchlorate by Mahle, Deirdre A., Yu, Kyung O., Narayanan, Latha, Mattie, David R., Fisher, Jeffrey W.

“…Ammonium perchlorate is used as an oxidizer in rocket fuel. It has become a groundwater contaminant, dissociating to ammonium cation and perchlorate anion. The…”
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Confirmation of a carboxylic acid metabolite of polychlorotrifluoroethylene and a method for its GC-ECD analysis in biological matrices by Greene, R J, Brashear, W T, Auten, K L, Mahle, D A

“…3.1 Oil, referred to as polychlorotrifluoroethylene (pCTFE), is a polymeric mixture consisting primarily of trimers and tetramers of chlorotrifluoroethylene…”
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