Search Results - "Mahlakõiv, Tanel"

Leukocyte-derived IFN-α/β and epithelial IFN-λ constitute a compartmentalized mucosal defense system that restricts enteric virus infections by Mahlakõiv, Tanel, Hernandez, Pedro, Gronke, Konrad, Diefenbach, Andreas, Staeheli, Peter

“…Epithelial cells are a major port of entry for many viruses, but the molecular networks which protect barrier surfaces against viral infections are…”
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Identification of continuous human B-cell epitopes in the VP35, VP40, nucleoprotein and glycoprotein of Ebola virus by Becquart, Pierre, Mahlakõiv, Tanel, Nkoghe, Dieudonné, Leroy, Eric M

“…Ebola virus (EBOV) is a highly virulent human pathogen. Recovery of infected patients is associated with efficient EBOV-specific immunoglobulin G (IgG)…”
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IFN-λ prevents influenza virus spread from the upper airways to the lungs and limits virus transmission by Klinkhammer, Jonas, Schnepf, Daniel, Ye, Liang, Schwaderlapp, Marilena, Gad, Hans Henrik, Hartmann, Rune, Garcin, Dominique, Mahlakõiv, Tanel, Staeheli, Peter

“…Host factors restricting the transmission of respiratory viruses are poorly characterized. We analyzed the contribution of type I and type III interferon (IFN)…”
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Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation by Nagashima, Hiroyuki, Mahlakõiv, Tanel, Shih, Han-Yu, Davis, Fred P., Meylan, Francoise, Huang, Yuefeng, Harrison, Oliver J., Yao, Chen, Mikami, Yohei, Urban, Joseph F., Caron, Kathleen M., Belkaid, Yasmine, Kanno, Yuka, Artis, David, O’Shea, John J.

“…Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling…”
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Targeted deletion of the TSLP receptor reveals cellular mechanisms that promote type 2 airway inflammation by Kabata, Hiroki, Flamar, Anne-Laure, Mahlakõiv, Tanel, Moriyama, Saya, Rodewald, Hans-Reimer, Ziegler, Steven F., Artis, David

“…Thymic stromal lymphopoietin (TSLP) is a critical upstream cytokine inducing type 2 inflammation in various diseases, including asthma and atopic dermatitis…”
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Interleukin-33 Induces the Enzyme Tryptophan Hydroxylase 1 to Promote Inflammatory Group 2 Innate Lymphoid Cell-Mediated Immunity by Flamar, Anne-Laure, Klose, Christoph S.N., Moeller, Jesper B., Mahlakõiv, Tanel, Bessman, Nicholas J., Zhang, Wen, Moriyama, Saya, Stokic-Trtica, Vladislava, Rankin, Lucille C., Putzel, Gregory Garbès, Rodewald, Hans-Reimer, He, Zhengxiang, Chen, Lili, Lira, Sergio A., Karsenty, Gerard, Artis, David

“…Group 2 innate lymphoid cells (ILC2s) regulate immunity, inflammation, and tissue homeostasis. Two distinct subsets of ILC2s have been described: steady-state…”
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IFN-λ determines the intestinal epithelial antiviral host defense by Pott, Johanna, Mahlakõiv, Tanel, Mordstein, Markus, Duerr, Claudia U., Michiels, Thomas, Stockinger, Silvia, Staeheli, Peter, Hornef, Mathias W., Hiscott, John

“…Type I and type III IFNs bind to different cell-surface receptors but induce identical signal transduction pathways, leading to the expression of antiviral…”
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The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation by Klose, Christoph S. N., Mahlakõiv, Tanel, Moeller, Jesper B., Rankin, Lucille C., Flamar, Anne-Laure, Kabata, Hiroki, Monticelli, Laurel A., Moriyama, Saya, Putzel, Gregory Garbès, Rakhilin, Nikolai, Shen, Xiling, Kostenis, Evi, König, Gabriele M., Senda, Takashi, Carpenter, Dustin, Farber, Donna L., Artis, David

“…Intestinal type 2 innate lymphoid cells express the neuropeptide receptor NMUR1, which makes them responsive to neuronal neuromedin U, thereby promoting a type…”
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Allergen Exposure: When Timing Is Everything by Mahlakõiv, Tanel, Artis, David

“…It is known that young children exposed to allergens are prone to develop asthma later in life. In this issue of Immunity, de Kleer et al. (2016) identify…”
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The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation by Wallrapp, Antonia, Riesenfeld, Samantha J., Burkett, Patrick R., Abdulnour, Raja-Elie E., Nyman, Jackson, Dionne, Danielle, Hofree, Matan, Cuoco, Michael S., Rodman, Christopher, Farouq, Daneyal, Haas, Brian J., Tickle, Timothy L., Trombetta, John J., Baral, Pankaj, Klose, Christoph S. N., Mahlakõiv, Tanel, Artis, David, Rozenblatt-Rosen, Orit, Chiu, Isaac M., Levy, Bruce D., Kowalczyk, Monika S., Regev, Aviv, Kuchroo, Vijay K.

“…Type 2 innate lymphoid cells (ILC2s) both contribute to mucosal homeostasis and initiate pathologic inflammation in allergic asthma. However, the signals that…”
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Neuropeptide regulation of non-redundant ILC2 responses at barrier surfaces by Tsou, Amy M., Yano, Hiroshi, Parkhurst, Christopher N., Mahlakõiv, Tanel, Chu, Coco, Zhang, Wen, He, Zhengxiang, Jarick, Katja J., Zhong, Connie, Putzel, Gregory G., Hatazaki, Mai, Lorenz, Ivo C., Andrew, David, Balderes, Paul, Klose, Christoph S. N., Lira, Sergio A., Artis, David

“…Emerging studies indicate that cooperation between neurons and immune cells regulates antimicrobial immunity, inflammation and tissue homeostasis. For example,…”
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Host microbiota constantly control maturation and function of microglia in the CNS by Erny, Daniel, Hrabě de Angelis, Anna Lena, Jaitin, Diego, Wieghofer, Peter, Staszewski, Ori, David, Eyal, Keren-Shaul, Hadas, Mahlakoiv, Tanel, Jakobshagen, Kristin, Buch, Thorsten, Schwierzeck, Vera, Utermöhlen, Olaf, Chun, Eunyoung, Garrett, Wendy S, McCoy, Kathy D, Diefenbach, Andreas, Staeheli, Peter, Stecher, Bärbel, Amit, Ido, Prinz, Marco

“…In this study, the authors show that host microbiota play a key role in modulating microglia homeostasis. Germ-free mice or mice with only limited microbiota…”
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Interferon-λ and interleukin 22 act synergistically for the induction of interferon-stimulated genes and control of rotavirus infection by Hernández, Pedro P, Mahlakõiv, Tanel, Yang, Ines, Schwierzeck, Vera, Nguyen, Nam, Guendel, Fabian, Gronke, Konrad, Ryffel, Bernhard, Hölscher, Christoph, Dumoutier, Laure, Renauld, Jean-Christophe, Suerbaum, Sebastian, Staeheli, Peter, Diefenbach, Andreas

“…Epithelial surfaces are the main entry point for viruses and thus are important immunological sites. Diefenbach and colleagues show that the related cytokines…”
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Type I and type III interferons drive redundant amplification loops to induce a transcriptional signature in influenza-infected airway epithelia by Crotta, Stefania, Davidson, Sophia, Mahlakoiv, Tanel, Desmet, Christophe J, Buckwalter, Matthew R, Albert, Matthew L, Staeheli, Peter, Wack, Andreas

“…Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to…”
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Human but not mouse hepatocytes respond to interferon-lambda in vivo by Hermant, Pascale, Demarez, Céline, Mahlakõiv, Tanel, Staeheli, Peter, Meuleman, Philip, Michiels, Thomas

“…The type III interferon (IFN) receptor is preferentially expressed by epithelial cells. It is made of two subunits: IFNLR1, which is specific to IFN-lambda…”
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Rotavirus susceptibility of antibiotic-treated mice ascribed to diminished expression of interleukin-22 by Schnepf, Daniel, Hernandez, Pedro, Mahlakõiv, Tanel, Crotta, Stefania, Sullender, Meagan E, Peterson, Stefan T, Ohnemus, Annette, Michiels, Camille, Gentle, Ian, Dumoutier, Laure, Reis, Celso A, Diefenbach, Andreas, Wack, Andreas, Baldridge, Megan T, Staeheli, Peter

“…The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric…”
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Correction: High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon by Becquart, Pierre, Wauquier, Nadia, Mahlakõiv, Tanel, Nkoghe, Dieudonné, Padilla, Cindy, Souris, Marc, Ollomo, Benjamin, Gonzalez, Jean-Paul, De Lamballerie, Xavier, Kazanji, Mirdad, Leroy, Eric M.

“…(2010) Correction: High Prevalence of Both Humoral and Cellular Immunity to Zaire ebolavirus among Rural Populations in Gabon. No competing interests declared…”
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Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance by Swamy, Mahima, Abeler-Dörner, Lucie, Chettle, James, Mahlakõiv, Tanel, Goubau, Delphine, Chakravarty, Probir, Ramsay, George, Reis e Sousa, Caetano, Staeheli, Peter, Blacklaws, Barbara A., Heeney, Jonathan L., Hayday, Adrian C.

“…Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial…”
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Activation of type III interferon genes by pathogenic bacteria in infected epithelial cells and mouse placenta by Bierne, Hélène, Travier, Laetitia, Mahlakõiv, Tanel, Tailleux, Ludovic, Subtil, Agathe, Lebreton, Alice, Paliwal, Anupam, Gicquel, Brigitte, Staeheli, Peter, Lecuit, Marc, Cossart, Pascale

“…Bacterial infections trigger the expression of type I and II interferon genes but little is known about their effect on type III interferon (IFN-λ) genes,…”
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Human placental hematopoietic stem cell-derived natural killer cells (CYNK) recognize and eliminate influenza A virus-infected cells by Gunasekaran, Manojkumar, Difiglia, Andrea, Fitzgerald, John, Hariri, Robert, van der Touw, William, Mahlakõiv, Tanel

“…Influenza A virus (IAV) infections are a significant recurrent threat to public health and a significant burden on global economy, highlighting the need for…”
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