Search Results - "Mahida, Y R"

Recent advances in Clostridium difficile-associated disease by Monaghan, T, Boswell, T, Mahida, Y R

“…The main purpose of this article is to review recent developments in the management of acute and recurrent Clostridium difficile-associated disease, with…”
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Expression profiling of Wnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells by Hughes, K.R., Sablitzky, F., Mahida, Y.R.

“…Background: Wnt signaling regulates intestinal epithelial stem cell function. Wnt ligands bind Frizzled (Fz) receptors and low‐density…”
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Expression and regulation of antimicrobial peptides in the gastrointestinal tract by Cunliffe, R. N., Mahida, Y. R.

“…The gastrointestinal (GI) tract is exposed to a wide range of microorganisms. The expression of antimicrobial peptides has been demonstrated in different…”
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Paneth cells: their role in innate immunity and inflammatory disease by Elphick, D A, Mahida, Y R

“…DCs also send processes between gut epithelial cells without disturbing tight junction integrity and sample commensal and pathogenic gut bacteria. 5 When T and…”
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Clostridium difficile associated diarrhoea in hospitalised patients: onset in the community and hospital and role of flexible sigmoidoscopy by Johal, S S, Hammond, J, Solomon, K, James, P D, Mahida, Y R

“…Objectives:Clostridium difficile associated diarrhoea (CDAD) is a hospital acquired infection in which optimal methods for diagnosis and the scale of the…”
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Characterization of putative stem cells in isolated human colonic crypt epithelial cells and their interactions with myofibroblasts by Samuel, S, Walsh, R, Webb, J, Robins, A, Potten, C, Mahida, Y R

“…Colonic epithelial stem cells are believed to be located at the crypt base where they have previously been shown to express musashi-1. The colonic stem cell…”
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Primary Human Colonic Myofibroblasts Are Resistant to Clostridium difficile Toxin A-Induced, but Not Toxin B-Induced, Cell Death by Mullan, N, Hughes, K.R, Mahida, Y.R

“…Colonic inflammation in Clostridium difficile infection is mediated by released toxins A and B. We investigated responses to C. difficile toxins A and B by…”
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Human defensin 5 is stored in precursor form in normal Paneth cells and is expressed by some villous epithelial cells and by metaplastic Paneth cells in the colon in inflammatory bowel disease by Cunliffe, R N, Rose, F R A J, Keyte, J, Abberley, L, Chan, W C, Mahida, Y R

“…BACKGROUND AND AIMS Intestinal epithelial cell derived antimicrobial peptides of the defensin family may play a major role in host defence against…”
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New concepts in C. difficile management by Mahida, Y R

“…Clostridium difficile infection is transmitted via spores, and the disease is mediated via secreted toxins. It represents a significant healthcare problem, and…”
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Cyclooxygenase (COX) 1 and 2 in normal, inflamed, and ulcerated human gastric mucosa by Jackson, L M, Wu, K C, Mahida, Y R, Jenkins, D, Hawkey, C J

“…BACKGROUND AND AIMS Constitutive cyclooxygenase (COX) 1 is believed to mediate prostaglandin dependent gastric protection. However, gastric mucosa contains…”
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Differential expression of TGF-beta isoforms by normal and inflammatory bowel disease intestinal myofibroblasts by McKaig, B C, Hughes, K, Tighe, P J, Mahida, Y R

“…Intestinal strictures are frequent in Crohn's disease but not ulcerative colitis. We investigated the expression of transforming growth factor (TGF)-beta…”
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Effect of Clostridium difficile toxin A on human intestinal epithelial cells: induction of interleukin 8 production and apoptosis after cell detachment by Mahida, Y R, Makh, S, Hyde, S, Gray, T, Borriello, S P

“…Clostridium difficile is the aetiological agent of pseudomembranous colitis, and animal studies suggest the essential role of secreted toxin A in inducing…”
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Monocytes Are Highly Sensitive to Clostridium difficile Toxin A-Induced Apoptotic and Nonapoptotic Cell Death by Solomon, K, Webb, J, Ali, N, Robins, R. A, Mahida, Y. R

“…In this study we investigated the in vitro responses of peripheral blood mononuclear preparations and purified monocytes to Clostridium difficile toxin A. In…”
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Expression of interleukin 1β and interleukin 1β converting enzyme by intestinal macrophages in health and inflammatory bowel disease by McAlindon, M E, Hawkey, C J, Mahida, Y R

“…Background—In the lipopolysaccharide (LPS) stimulated peripheral blood monocyte, the precursor form of interleukin 1β (IL-1β, 31 kD) is processed by IL-1β…”
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Essential role of toxin A in C. difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function by Sutton, P.A, Li, S, Webb, J, Solomon, K, Brazier, J, Mahida, Y.R

“…Clostridium difficile induces mucosal inflammation via secreted toxins A and B and initial interactions between the toxins and intestinal epithelial cells…”
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Expression of antimicrobial neutrophil defensins in epithelial cells of active inflammatory bowel disease mucosa by Cunliffe, R N, Kamal, M, Rose, F R A J, James, P D, Mahida, Y R

“…Background/Aims: The normal intestinal epithelium is increasingly being recognised as an important component of the mucosal innate protection against…”
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Potential Role of Epithelial Cell-Derived Histone H1 Proteins in Innate Antimicrobial Defense in the Human Gastrointestinal Tract by ROSE, F. R. A. J, BAILEY, K, KEYTE, J. W, CHAN, W. C, GREENWOOD, D, MAHIDA, Y. R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Mucosal T cells regulate Paneth and intermediate cell numbers in the small intestine of T. spiralis‐infected mice by Kamal, M., Wakelin, D., Ouellette, A. J., Smith, A., Podolsky, D. K., Mahida, Y. R.

“…Secretions of Paneth, intermediate and goblet cells have been implicated in innate intestinal host defense. We have investigated the role of T cells in…”
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Epithelial stem cell-related alterations in Trichinella spiralis-infected small intestine by Walsh, R., Seth, R., Behnke, J., Potten, C. S., Mahida, Y. R.

“…Objectives:  Infection of mice with the parasite Trichinella spiralis leads to small intestinal inflammation, characterized by changes in mucosal architecture…”
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Adult human colonic subepithelial myofibroblasts express extracellular matrix proteins and cyclooxygenase-1 and -2 by Mahida, Y R, Beltinger, J, Makh, S, Göke, M, Gray, T, Podolsky, D K, Hawkey, C J

“…Interactions between epithelial cells and subepithelial myofibroblasts are increasingly recognized as important in the regulation of epithelial cell function…”
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