Search Results - "Mahesh, K C"

Assessment of two DNA extraction kits for profiling poultry respiratory microbiota from multiple sample types by Abundo, Michael E C, Ngunjiri, John M, Taylor, Kara J M, Ji, Hana, Ghorbani, Amir, K C, Mahesh, Weber, Bonnie P, Johnson, Timothy J, Lee, Chang-Won

“…Characterization of poultry microbiota is becoming increasingly important due to the growing need for microbiome-based interventions to improve poultry health…”
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Recombinant measles virus expressing prefusion spike protein stabilized by six rather than two prolines is more efficacious against SARS‐CoV‐2 infection by Zhang, Yuexiu, Lu, Mijia, Thongpan, Ilada, Xu, Jiayu, KC, Mahesh, Dravid, Piyush, Trivedi, Sheetal, Sharma, Himanshu, Liang, Xueya, Kapoor, Amit, Peeples, Mark E., Li, Jianrong

“…Measles virus (MeV) has been an excellent vector platform for delivering vaccines against many pathogens because of its high safety and efficacy, and induction…”
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SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern by Lu, Mijia, Chamblee, Michelle, Zhang, Yuexiu, Ye, Chengjin, Dravid, Piyush, Park, Jun-Gyu, Mahesh, K C, Trivedi, Sheetal, Murthy, Satyapramod, Sharma, Himanshu, Cassady, Cole, Chaiwatpongsakorn, Supranee, Liang, Xueya, Yount, Jacob S, Boyaka, Prosper N, Peeples, Mark E, Martinez-Sobrido, Luis, Kapoor, Amit, Li, Jianrong

“…The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main target for neutralizing antibodies (NAbs). The S protein…”
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Protective immunity against influenza virus challenge by norovirus P particle-M2e and HA2-AtCYN vaccines in chickens by Elaish, Mohamed, Xia, Ming, Ngunjiri, John M, Ghorbani, Amir, Jang, Hyesun, KC, Mahesh, Abundo, Michael C, Dhakal, Santosh, Gourapura, Renukaradhya, Jiang, Xi, Lee, Chang-Won

“…AbstractDevelopment of a broadly reactive influenza vaccine that can provide protection against emerging type A influenza viruses is a big challenge. We…”
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Interferon‐induced transmembrane protein 3 (IFITM3) limits lethality of SARS‐CoV‐2 in mice by Kenney, Adam D, Zani, Ashley, Kawahara, Jeffrey, Eddy, Adrian C, Wang, Xiao‐Liang, Mahesh, KC, Lu, Mijia, Thomas, Jeronay, Kohlmeier, Jacob E, Suthar, Mehul S, Hemann, Emily A, Li, Jianrong, Peeples, Mark E, Hall‐Stoodley, Luanne, Forero, Adriana, Cai, Chuanxi, Ma, Jianjie, Yount, Jacob S

“…Interferon‐induced transmembrane protein 3 (IFITM3) is an antiviral protein that alters cell membranes to block fusion of viruses. Conflicting reports…”
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Prime-Pull Immunization of Mice with a BcfA-Adjuvanted Vaccine Elicits Sustained Mucosal Immunity That Prevents SARS-CoV-2 Infection and Pathology by Shamseldin, Mohamed M, Kenney, Adam, Zani, Ashley, Evans, John P, Zeng, Cong, Read, Kaitlin A, Hall, Jesse M, Chaiwatpongsakorn, Supranee, Mahesh, K C, Lu, Mijia, Eltobgy, Mostafa, Denz, Parker, Deora, Rajendar, Li, Jianrong, Peeples, Mark E, Oestreich, Kenneth J, Liu, Shan-Lu, Corps, Kara N, Yount, Jacob S, Dubey, Purnima

“…Vaccines against SARS-CoV-2 that induce mucosal immunity capable of preventing infection and disease remain urgently needed. In this study, we demonstrate the…”
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Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective by Zhang, Yuexiu, Chamblee, Michelle, Xu, Jiayu, Qu, Panke, Shamseldin, Mohamed M., Yoo, Sung J., Misny, Jack, Thongpan, Ilada, KC, Mahesh, Hall, Jesse M., Gupta, Yash A., Evans, John P., Lu, Mijia, Ye, Chengjin, Hsu, Cheng Chih, Liang, Xueya, Martinez-Sobrido, Luis, Yount, Jacob S., Boyaka, Prosper N., Liu, Shan-Lu, Dubey, Purnima, Peeples, Mark E., Li, Jianrong

“…As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed…”
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Farm Stage, Bird Age, and Body Site Dominantly Affect the Quantity, Taxonomic Composition, and Dynamics of Respiratory and Gut Microbiota of Commercial Layer Chickens by Ngunjiri, John M, Taylor, Kara J M, Abundo, Michael C, Jang, Hyesun, Elaish, Mohamed, Kc, Mahesh, Ghorbani, Amir, Wijeratne, Saranga, Weber, Bonnie P, Johnson, Timothy J, Lee, Chang-Won

“…The digestive and respiratory tracts of chickens are colonized by bacteria that are believed to play important roles in the overall health and performance of…”
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Avian Toll-like receptor 3 isoforms and evaluation of Toll-like receptor 3–mediated immune responses using knockout quail fibroblast cells by KC, Mahesh, Ngunjiri, John M., Lee, Joonbum, Ahn, Jinsoo, Elaish, Mohamed, Ghorbani, Amir, Abundo, Michael E.C., Lee, Kichoon, Lee, Chang-Won

“…Toll-like receptor 3 (TLR3) induces host innate immune response on recognition of viral double-stranded RNA (dsRNA). Although several studies of avian TLR3…”
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Assessment of TLR3 and MDA5-Mediated Immune Responses Using Knockout Quail Fibroblast Cells by Mahesh, K C, Ngunjiri, John M, Ghorbani, Amir, Abundo, Michael E C, Wilbanks, Kathryn Q, Lee, Kichoon, Lee, Chang-Won

“…Toll-like receptor 3 (TLR3) and melanoma differentiation-associated gene 5 (MDA5) are double-stranded RNA (dsRNA)-recognizing receptors that mediate innate…”
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Kinetics of lithium insertion into LiMnPO4 from aqueous saturated LiOH: A study using galvanostatic and potentiostatic intermittent titration techniques by Manjunatha, H., Mahesh, K.C., Suresh, G.S., Venkatesha, T.V.

“…Galvanostatic and potentiostatic intermittent titration techniques have been used to study the lithium ion insertion into LiMnPO4 from aqueous sat. LiOH…”
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Influenza A virus infection in turkeys induces respiratory and enteric bacterial dysbiosis correlating with cytokine gene expression by Ngunjiri, John M, Taylor, Kara J.M, Ji, Hana, Abundo, Michael C, Ghorbani, Amir, KC, Mahesh, Lee, Chang-Won

“…Turkey respiratory and gut microbiota play important roles in promoting health and production performance. Loss of microbiota homeostasis due to pathogen…”
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Influenza A virus modulates ACE2 expression and SARS-CoV-2 infectivity in human cardiomyocytes by Wu, Qian, Kumar, Naresh, Lafuse, William P., Ahumada, Omar Santiagonunez, Saljoughian, Noushin, Whetstone, Elizabeth, Zani, Ashley, Patton, Ashley K., El Refaey, Mona, Webb, Amy, Pietrzak, Maciej, Yu, Lianbo, KC, Mahesh, Peeples, Mark E., Ganesan, Latha P., Yount, Jacob S., Rajaram, Murugesan V.S.

“…Influenza A virus (IAV) and SARS-CoV-2 virus are both acute respiratory viruses currently circulating in the human population. This study aims to determine the…”
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SB-robust estimator for the concentration parameter of circular normal distribution by Laha, Arnab Kumar, Mahesh, K. C.

“…In this paper we discuss robust estimation of the concentration parameter ( κ ) of the circular normal (CN) distribution. It is known that the MLE of the…”
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A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike by Lu, Mijia, Dravid, Piyush, Zhang, Yuexiu, Trivedi, Sheetal, Li, Anzhong, Harder, Olivia, KC, Mahesh, Chaiwatpongsakorn, Supranee, Zani, Ashley, Kenney, Adam, Zeng, Cong, Cai, Chuanxi, Ye, Chengjin, Liang, Xueya, Shimamura, Masako, Liu, Shan-Lu, Mejias, Asuncion, Ramilo, Octavio, Boyaka, Prosper N., Qiu, Jianming, Martinez-Sobrido, Luis, Yount, Jacob S., Peeples, Mark E., Kapoor, Amit, Niewiesk, Stefan, Li, Jianrong

“…The current pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights an urgent need to develop a safe,…”
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TLR3 and MDA5 Knockout DF-1 cells Enhance Replication of Avian Orthoavulavirus 1 by Lee, Chang-Won, Kc, Mahesh, Ngunjiri, John M, Ghorbani, Amir, Lee, Kichoon

“…Despite the essential role of innate immunity in defining the outcome of viral infections, the roles played by different components of the avian innate immune…”
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A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike by Zhang, Yuexiu, Lu, Mijia, Mahesh, K C, Kim, Eunsoo, Shamseldin, Mohamed M, Ye, Chengjin, Dravid, Piyush, Chamblee, Michelle, Park, Jun-Gyu, Hall, Jesse M, Trivedi, Sheetal, Chaiwatpongsakorn, Supranee, Kenny, Adam D, Murthy, Satyapramod Srinivasa, Sharma, Himanshu, Liang, Xueya, Yount, Jacob S, Kapoor, Amit, Martinez-Sobrido, Luis, Dubey, Purnima, Boyaka, Prosper N, Peeples, Mark E, Li, Jianrong

“…With the rapid increase in SARS-CoV-2 cases in children, a safe and effective vaccine for this population is urgently needed. The MMR (measles/mumps/rubella)…”
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Heterosubtypic protection against avian influenza virus by live attenuated and chimeric norovirus P-particle-M2e vaccines in chickens by Ghorbani, Amir, Ngunjiri, John M., Xia, Ming, Elaish, Mohamed, Jang, Hyesun, Mahesh, K.C., Abundo, Michael C., Jiang, Xi, Lee, Chang-Won

“…Avian influenza in poultry continues to be a great concern worldwide, and the currently licensed inactivated influenza vaccines are not effective against the…”
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Evaluation of Sampling Methods for the Study of Avian Respiratory Microbiota by C. Abundo, Michael Edward, Ngunjiri, John M., Taylor, Kara J. M., Ji, Hana, Ghorbani, Amir, KC, Mahesh, Elaish, Mohamed, Jang, Hyesun, Weber, Bonnie, Johnson, Timothy J., Lee, Chang-Won

“…Although poultry microbiome discoveries are increasing due to the potential impact on poultry performance, studies examining the poultry respiratory microbiome…”
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Specific-pathogen-free Turkey model for reoviral arthritis by Ngunjiri, John M., Ghorbani, Amir, Jang, Hyesun, Waliullah, Sumyya, Elaish, Mohamed, Abundo, Michael C., KC, Mahesh, Taylor, Kara J.M., Porter, Robert E., Lee, Chang-Won

“…•TARV-infected SPF turkeys recapitulate the disease observed in commercial turkeys.•Reoviral arthritis features in SPF turkeys include: hock joint swelling,…”
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