Search Results - "Maher, Veronica M"

Rev7/Mad2B plays a critical role in the assembly of a functional mitotic spindle by Bhat, Audesh, Wu, Zhaojia, Maher, Veronica M, McCormick, J Justin, Xiao, Wei

“…The spindle assembly checkpoint (SAC) acts as a guardian against cellular threats that may lead to chromosomal missegregation and aneuploidy. Mad2, an…”
Get full text

Down-regulation of overexpressed Sp1 protein in human fibrosarcoma cell lines inhibits tumor formation by ZHENJUN LOU, O'REILLY, Sandra, HONGYAN LIANG, MAHER, Veronica M, SLEIGHT, Stuart D, MCCORMICK, J. Justin

“…Sp1 is a transcription factor for many genes, including genes involved in tumorigenesis. We found that human fibroblast cells malignantly transformed in…”
Get full text

Evidence That Sprouty 2 Is Necessary for Sarcoma Formation by H-Ras Oncogene-transformed Human Fibroblasts by Lito, Piro, Mets, Bryan D., Kleff, Susanne, O'Reilly, Sandra, Maher, Veronica M., McCormick, J. Justin

“…Sprouty 2 (Spry2) acts as an inhibitor of receptor tyrosine kinase signaling in various cellular contexts. Interestingly, Spry2 also prevents the c-Cbl-induced…”
Get full text

Sprouty 2 Regulates DNA Damage-induced Apoptosis in Ras-transformed Human Fibroblasts by Lito, Piro, Mets, Bryan D., Appledorn, Daniel M., Maher, Veronica M., McCormick, J. Justin

“…We have reported that expression of Sprouty 2 (Spry2) is necessary for tumor formation by HRasV12-transformed fibroblasts. We now report on the role of Spry2…”
Get full text

A Human Homolog of the Saccharomyces cerevisiae REV3 Gene, which Encodes the Catalytic Subunit of DNA Polymerase ζ by Peter E. M. Gibbs, McGregor, W. Glenn, Maher, Veronica M., Nisson, Paul, Lawrence, Christopher W.

“…To get a better understanding of mutagenic mechanisms in humans, we have cloned and sequenced the human homolog of the Saccharomyces cerevisiae REV3 gene. The…”
Get full text

Identification of a Protein Essential for a Major Pathway Used by Human Cells to Avoid UV-Induced DNA Damage by Li, Ziqiang, Xiao, Wei, McCormick, J. Justin, Maher, Veronica M.

“…When DNA replication stalls at a fork-blocking lesion, cells use damage tolerance pathways to continue replication. One pathway, "translesion synthesis,"…”
Get full text

Evidence that in xeroderma pigmentosum variant cells, which lack DNA polymerase eta, DNA polymerase iota causes the very high frequency and unique spectrum of UV-induced mutations by Wang, Yun, Woodgate, Roger, McManus, Terrence P, Mead, Samantha, McCormick, J Justin, Maher, Veronica M

“…Xeroderma pigmentosum variant (XPV) patients have normal DNA excision repair, yet are predisposed to develop sunlight-induced cancer. They exhibit a 25-fold…”
Get full text

Malignant transformation of human skin fibroblasts by two alternative pathways by McCormick, J Justin, Maher, Veronica M

“…We developed a telomerase-positive, infinite life span human fibroblast cell strain (MSU-1.0) by transfection of a v-MYC oncogene and spontaneous…”
Get more information

hRev7, putative subunit of hPolζ, plays a critical role in survival, induction of mutations, and progression through S-phase, of UV (254 nm) -irradiated human fibroblasts by McNally, Kristin, Neal, Jessica A., McManus, Terrence P., McCormick, J. Justin, Maher, Veronica M.

“…Translesion synthesis (TLS) refers to mechanisms by which specialized DNA polymerases incorporate nucleotides opposite fork-blocking lesions and extend…”
Get full text

The Function of the Human Homolog of Saccharomyces cerevisiae REV1 Is Required for Mutagenesis Induced by UV Light by Peter E. M. Gibbs, Wang, Xi-De, Li, Ziqiang, McManus, Terrence P., McGregor, W. Glenn, Lawrence, Christopher W., Maher, Veronica M.

“…In Saccharomyces cerevisiae, most mutations induced by a wide range of mutagens arise during translesion replication employing the REV1 gene product and DNA…”
Get full text

Mutagenesis in eukaryotes dependent on DNA polymerase zeta and Rev1p by Lawrence, Christopher W., Maher, Veronica M.

“…DNA polymerase zeta (Pol ζ) and Rev1p carry out translesion replication in budding yeast,…”
Get full text

Overview of matrix metalloproteinase expression in cultured human cells by Giambernardi, Troy A., Grant, George M., Taylor, Gail P., Hay, Robert J., Maher, Veronica M., Mccormick, J.Justin, Klebe, Robert J.

“…The matrix metalloproteinases (MMP) have been implicated in tumor invasion and metastasis both by immunohistochemical studies and from the observation that…”
Get full text

Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts by Appledorn, Daniel M, Dao, Kim-Hien T, O'Reilly, Sandra, Maher, Veronica M, McCormick, J Justin

“…The activities of Rac1 and Cdc42 are essential for HRas-induced transformation of rodent fibroblasts. What is more, expression of constitutively activated…”
Get full text

ST7 Is a Novel Low-Density Lipoprotein Receptor-Related Protein (LRP) with a Cytoplasmic Tail that Interacts with Proteins Related to Signal Transduction Pathways by Battle, Michele A, Maher, Veronica M, McCormick, J. Justin

“…In 1997, McCormick and co-workers identified a novel putative tumor suppressor gene, designated ST7, encoding a unique protein with transmembrane receptor…”
Get full text

The role of hRev7, the accessory subunit of hPolζ, in translesion synthesis past DNA damage induced by benzo[a]pyrene diol epoxide (BPDE) by Neal, Jessica A, Fletcher, Kathryn L, McCormick, J Justin, Maher, Veronica M

“…DNA polymerase zeta (Polζ) is a specialized DNA polymerase that, unlike classical replicative polymerases, is capable of replicating past DNA lesions, i.e. of…”
Get full text

Identification of the promoter of human transcription factor Sp3 and evidence of the role of factors Sp1 and Sp3 in the expression of Sp3 protein by Lou, Zhenjun, Maher, Veronica M., McCormick, J. Justin

“…In a study of the role of transcription factor Sp1 in the formation of tumors by human fibrosarcoma cell lines that overexpress it [Cancer Res., 65 (2005)…”
Get full text

Sp1 regulates expression of MET, and ribozyme-induced down-regulation of MET in fibrosarcoma-derived human cells reduces or eliminates their tumorigenicity by Liang, Hongyan, O'Reilly, Sandra, Liu, Youhua, Abounader, Roger, Laterra, John, Maher, Veronica M, McCormick, J Justin

“…Changes in expression of hepatocyte growth factor (HGF) and its receptor, MET, are associated with formation and malignant progression of human tumors. In the…”
Get more information

Abnormal, Error-Prone Bypass of Photoproducts by Xeroderma Pigmentosum Variant Cell Extracts Results in Extreme Strand Bias for the Kinds of Mutations Induced by UV Light by McGregor, W. Glenn, Wei, Dong, Maher, Veronica M., McCormick, J. Justin

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Suppression of anchorage-independent growth and matrigel invasion and delayed tumor formation by elevated expression of fibulin-1D in human fibrosarcoma-derived cell lines by QING, J, MAHER, V. M, TRAN, H, ARGRAVES, W. S, DUNSTAN, R. W, MCCORMICK, J. J

“…Using differential display, we identified an mRNA that is markedly down-regulated in cell line 6A/SB1, derived from a fibrosarcoma formed in an athymic mouse…”
Get full text

Mismatch repair is required for O(6)-methylguanine-induced homologous recombination in human fibroblasts by Zhang, H, Marra, G, Jiricny, J, Maher, V M, McCormick, J J

“…O:(6)-methylguanine is responsible for homologous recombination induced by N:-methyl-N:'-nitro-N:-nitrosoguanidine (MNNG) [H. Zhang et al. (1996)…”
Get full text