Search Results - "Maher, Timothy J"

Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation by Tyler, Paul M., Bucklin, Molly L., Zhao, Mengting, Maher, Timothy J., Rice, Andrew J., Ji, Weizhen, Warner, Neil, Pan, Jie, Morotti, Raffaella, McCarthy, Paul, Griffiths, Anne, van Rossum, Annemarie M. C., Hollink, Iris H.I.M., Dalm, Virgil A.S.H., Catanzaro, Jason, Lakhani, Saquib A., Muise, Aleixo M., Lucas, Carrie L.

“…Transcription factors specialized to limit the destructive potential of inflammatory immune cells remain ill-defined. We discovered loss-of-function variants…”
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Human PI3Kγ deficiency and its microbiota-dependent mouse model reveal immunodeficiency and tissue immunopathology by Takeda, Andrew J., Maher, Timothy J., Zhang, Yu, Lanahan, Stephen M., Bucklin, Molly L., Compton, Susan R., Tyler, Paul M., Comrie, William A., Matsuda, Makoto, Olivier, Kenneth N., Pittaluga, Stefania, McElwee, Joshua J., Long Priel, Debra A., Kuhns, Douglas B., Williams, Roger L., Mustillo, Peter J., Wymann, Matthias P., Koneti Rao, V., Lucas, Carrie L.

“…Phosphatidylinositol 3-kinase-gamma (PI3Kγ) is highly expressed in leukocytes and is an attractive drug target for immune modulation. Different experimental…”
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Ingestion of Mn and Pb by rats during and after pregnancy alters iron metabolism and behavior in offspring by Molina, Ramon M., Phattanarudee, Siripan, Kim, Jonghan, Thompson, Khristy, Wessling-Resnick, Marianne, Maher, Timothy J., Brain, Joseph D.

“…► Rat dams were exposed to Mn or Pb in drinking water during pregnancy and lactation. ► Mn and Pb maternal exposures altered iron metabolism and behavior in…”
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Iron-responsive olfactory uptake of manganese improves motor function deficits associated with iron deficiency by Kim, Jonghan, Li, Yuan, Buckett, Peter D, Böhlke, Mark, Thompson, Khristy J, Takahashi, Masaya, Maher, Timothy J, Wessling-Resnick, Marianne

“…Iron-responsive manganese uptake is increased in iron-deficient rats, suggesting that toxicity related to manganese exposure could be modified by iron status…”
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Restorative effects of uridine plus docosahexaenoic acid in a rat model of Parkinson's disease by Cansev, Mehmet, Ulus, Ismail H., Wang, Lei, Maher, Timothy J., Wurtman, Richard J.

“…Administering uridine-5′-monophosphate (UMP) and docosahexaenoic acid (DHA) increases synaptic membranes (as characterized by pre- and post-synaptic proteins)…”
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Acetyl-l-carnitine reduces the infarct size and striatal glutamate outflow following focal cerebral ischemia in rats by Jalal, Fakhreya Yousuf, Böhlke, Mark, Maher, Timothy J.

“…Acetyl‐l‐carnitine (ALCAR), an endogenous water soluble molecule, is synthesized in the brain and is involved in many aspects of neuronal activity, including…”
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High Concentrations of Rosiglitazone Reduce mRNA and Protein Levels of LRP1 in HepG2 Cells by Rondón-Ortiz, Alejandro N, Lino Cardenas, Christian L, Martínez-Málaga, Jimena, Gonzales-Urday, Ana L, Gugnani, Kuljeet S, Böhlke, Mark, Maher, Timothy J, Pino-Figueroa, Alejandro J

“…Low-density lipoprotein receptor-related protein 1 (LRP1) is an endocytic receptor involved in the uptake of a variety of molecules, such as apoE,…”
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Neurobehavioral effects of lead and manganese individually and in combination in developmentally exposed rats by Betharia, Swati, Maher, Timothy J.

“…► Low level developmental exposures to Pb, Mn or their mixture result in gender specific behavioral effects. ► Effects on body weight, surface righting,…”
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effects of drug transporter inhibitors on the pharmacokinetics and tissue distribution of methotrexate in normal and tumor-bearing mice: a microdialysis study by Sani, Shabnam N, Henry, Katherine, Böhlke, Mark, Kim, Jonghan, Stricker-Krongrad, Alain, Maher, Timothy J

“…Purpose To examine methotrexate (MTX) tumor delivery in a mouse model using an in vivo microdialysis technique and to characterize the impact of prior…”
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Neuroprotective activity of macamides on manganese-induced mitochondrial disruption in U-87 MG glioblastoma cells by Gugnani, Kuljeet S., Vu, Nguyen, Rondón-Ortiz, Alejandro N., Böhlke, Mark, Maher, Timothy J., Pino-Figueroa, Alejandro J.

“…Macamides are a distinct class of secondary metabolites, benzylamides of long chain fatty acids, which were isolated from the Peruvian plant Lepidium meyenii…”
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Tyrosine prevents effects of hyperthermia on behavior and increases norepinephrine by Lieberman, Harris R., Georgelis, James H., Maher, Timothy J., Yeghiayan, Sylva K.

“…Tyrosine (TYR) is the precursor of the catecholamine (CA) neurotransmitters, dopamine (DA) and norepinephrine (NE). Catecholamines, especially NE, participate…”
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Cardiovascular responses and neurotransmitter changes during blockade of angiotensin II receptors within the ventrolateral medulla by Patel, Dipan, Böhlke, Mark, Phattanarudee, Siripan, Kabadi, Shruti, Maher, Timothy J., Ally, Ahmmed

“…Angiotensin II (Ang II) receptors are located in different regions of the brain, particularly within the cardiovascular control centers in the brainstem. These…”
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Neuroprotective effects of Lepidium meyenii (Maca) by Pino-Figueroa, Alejandro, Nguyen, Diane, Maher, Timothy J.

“…The neuroprotective activity of the plant Lepidium meyenii (Maca) was studied in two experimental models: in vitro and in vivo. Crayfish neurons were…”
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Transcranial focused ultrasound to the thalamus is associated with reduced extracellular GABA levels in rats by Yang, Po Song, Kim, Hyungmin, Lee, Wonhye, Bohlke, Mark, Park, Shinsuk, Maher, Timothy J, Yoo, Seung-Schik

“…Transcranial focused ultrasound (FUS), with its ability to non-invasively modulate the excitability of region-specific brain areas, is gaining attention as a…”
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Macamides and their synthetic analogs: Evaluation of in vitro FAAH inhibition by Wu, Hui, Kelley, Charles J., Pino-Figueroa, Alejandro, Vu, Huyen D., Maher, Timothy J.

“…Maca (Lepidium meyenii), a traditional food crop of the Peruvian Andes is now widely touted as a dietary supplement. Among the various chemical constituents…”
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Synthesis, anticoagulant and PIVKA-II induced by new 4-hydroxycoumarin derivatives by Abdelhafez, Omaima M., Amin, Kamelia M., Batran, Rasha Z., Maher, Timothy J., Nada, Somaia A., Sethumadhavan, Shalini

“…3-Pyridinyl, pyrimidinyl and pyrazolyl-4-hydroxycoumarin derivatives were synthesized. A comparative in vivo (CT, PT determination) and in vitro (measurement…”
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New quinolone derivatives as neuropeptide S receptor antagonists: Design, synthesis, homology modeling, dynamic simulations and modulation of Gq/Gs signaling pathways by Batran, Rasha Z., Gugnani, Kuljeet S., Maher, Timothy J., Khedr, Mohammed A.

“…[Display omitted] •New quinolinyl pyranopyrimidines were synthesized as NPSR antagonists.•Compound 10 was significant ligand against Ca+2…”
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Medullary monoamines and NMDA-receptor regulation of cardiovascular responses during peripheral nociceptive stimuli by Karlsson, Gudbjorn A., Preuss, Charles V., Chaitoff, Kevin A., Maher, Timothy J., Ally, Ahmmed

“…We have previously reported that AMPA-receptor blockade within the rostral ventrolateral medulla (RVLM) attenuates cardiovascular responses and extracellular…”
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New Coumarin Derivatives as Anti-Breast and Anti-Cervical Cancer Agents Targeting VEGFR-2 and p38[alpha] MAPK by Batran, Rasha Z, Dawood, Dina H, El-Seginy, Samia A, Ali, Mamdouh M, Maher, Timothy J, Gugnani, Kuljeet S, Rondon-Ortiz, Alejandro N

“…Breast and cervical cancers are the most common gender-specific cancers affecting women worldwide. In this investigation, we highlighted the synthesis, VEGFR-2…”
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Nitric oxide within periaqueductal gray modulates glutamatergic neurotransmission and cardiovascular responses during mechanical and thermal stimuli by Ishide, Takeshi, Amer, Ahmed, Maher, Timothy J., Ally, Ahmmed

“…We have previously reported that nitric oxide (NO) within the rostral ventrolateral medulla (RVLM) attenuates cardiovascular responses and extracellular…”
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