Search Results - "Mahendra, Premini"

Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers by Cobbold, Mark, Khan, Naeem, Pourgheysari, Batoul, Tauro, Sudhir, McDonald, Dorothy, Osman, Husam, Assenmacher, Mario, Billingham, Lucinda, Steward, Colin, Crawley, Charles, Olavarria, Eduardo, Goldman, John, Chakraverty, Ronjon, Mahendra, Premini, Craddock, Charles, Moss, Paul A H

“…Stem cell transplantation is used widely in the management of a range of diseases of the hemopoietic system. Patients are immunosuppressed profoundly in the…”
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CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation by Piper, Karen P., Horlock, Claire, Curnow, S. John, Arrazi, Julie, Nicholls, Sarah, Mahendra, Premini, Craddock, Charles, Moss, Paul A.H.

“…Acute graft-versus-host disease (aGVHD) remains a serious complication following allogeneic stem-cell transplantation (SCT), and is mediated by infiltration of…”
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Allogeneic Stem-Cell Transplantation Using a Reduced-Intensity Conditioning Regimen Has the Capacity to Produce Durable Remissions and Long-Term Disease-Free Survival in Patients With High-Risk Acute Myeloid Leukemia and Myelodysplasia by TAURO, Sudhir, CRADDOCK, Charles, KHWAJA, Asim, CHOPRA, Raj, LITTLEWOOD, Timothy, PENIKET, Andrew, PARKER, Anne, JACKSON, Graham, HALE, Geoff, COOK, Mark, RUSSELL, Nigel, MACKINNON, Stephen, PEGGS, Karl, BEGUM, Gulnaz, MAHENDRA, Premini, COOK, Gordon, MARSH, Judith, MILLIGAN, Donald, GOLDSTONE, Anthony, HUNTER, Ann

“…The toxicity of allogeneic stem-cell transplantation can be substantially reduced using a reduced-intensity conditioning (RIC) regimen. This has increased the…”
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High incidence of cytomegalovirus infection after nonmyeloablative stem cell transplantation: potential role of Campath-1H in delaying immune reconstitution by Chakrabarti, Suparno, Mackinnon, Stephen, Chopra, Raj, Kottaridis, Panagiotis D., Peggs, Karl, O'Gorman, Peter, Chakraverty, Ronjon, Marshall, Timothy, Osman, Husam, Mahendra, Premini, Craddock, Charles, Waldmann, Herman, Hale, Geoff, Fegan, Christopher D., Yong, Kwee, Goldstone, Anthony H., Linch, David C., Milligan, Donald W.

“…Nonmyeloablative conditioning is increasingly used for transplantation in a wide range of diseases, but little is known about its impact on the incidence of…”
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Limiting transplantation-related mortality following unrelated donor stem cell transplantation by using a nonmyeloablative conditioning regimen by Chakraverty, Ronjon, Peggs, Karl, Chopra, Rajesh, Milligan, Donald W., Kottaridis, Panagiotis D., Verfuerth, Stephanie, Geary, Johanne, Thuraisundaram, Dharsha, Branson, Kate, Chakrabarti, Suparno, Mahendra, Premini, Craddock, Charles, Parker, Anne, Hunter, Ann, Hale, Geoff, Waldmann, Herman, Williams, Catherine D., Yong, Kwee, Linch, David C., Goldstone, Anthony H., Mackinnon, Stephen

“…A nonmyeloablative conditioning regimen was investigated in 47 patients with hematological malignancy receiving allogeneic progenitor cells from matched,…”
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In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation by Kottaridis, Panagiotis D., Milligan, Donald W., Chopra, Rajesh, Chakraverty, Ronjon K., Chakrabarti, Suparno, Robinson, Stephen, Peggs, Karl, Verfuerth, Stephanie, Pettengell, Ruth, Marsh, Judith C.W., Schey, Stephen, Mahendra, Premini, Morgan, Gareth J., Hale, Geoff, Waldmann, Herman, de Elvira, M. Carmen Ruiz, Williams, Catherine D., Devereux, Stephen, Linch, David C., Goldstone, Anthony H., Mackinnon, Stephen

“…A novel nonmyeloablative conditioning regimen was investigated in 44 patients with hematologic malignancies. The median patient age was 41 years. Many of the…”
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Secondary anchor polymorphism in the HA-1 minor histocompatibility antigen critically affects MHC stability and TCR recognition by Nicholls, Sarah, Piper, Karen P, Mohammed, Fiyaz, Dafforn, Timothy R, Tenzer, Stefan, Salim, Mahboob, Mahendra, Premini, Craddock, Charles, van Endert, Peter, Schild, Hansjörg, Cobbold, Mark, Engelhard, Victor H, Moss, Paul A.H, Willcox, Benjamin E

“…T cell recognition of minor histocompatibility antigens (mHags) underlies allogeneic immune responses that mediate graft-versus-host disease and the…”
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CD8+ T-cell immunity against cancer-testis antigens develops following allogeneic stem cell transplantation and reveals a potential mechanism for the graft-versus-leukemia effect by MCLARNON, Andrew, PIPER, Karen P, GOODYEAR, Oliver C, ARRAZI, Julie M, MAHENDRA, Premini, COOK, Mark, CLARK, Fiona, PRATT, Guy, CRADDOCK, Charles, MOSS, Paul A. H

“…Allogeneic stem cell transplantation is associated with a powerful 'graft-versus-leukemia' effect that is generally considered to result from an alloreactive…”
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An ABVD-Based Approach Confers Superior Outcomes for Adolescent and Young Adult Patients Compared to Other Adults with Advanced Classical Hodgkin Lymphoma by Burns, David M, Bacon, Andrew, Wong, Timothy HT, Pratt, Guy, Clark, Fiona J, Mahendra, Premini, Chaganti, Sridhar, Malladi, Ram

“…Combination chemotherapy with ABVD is widely used as first line therapy for adult classical Hodgkin lymphoma (cHL). However, for patients in the Adolescent and…”
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Clinical evidence of a graft-versus-Hodgkin's-lymphoma effect after reduced-intensity allogeneic transplantation by Peggs, Karl S, Hunter, Ann, Chopra, Rajesh, Parker, Anne, Mahendra, Premini, Milligan, Donald, Craddock, Charles, Pettengell, Ruth, Dogan, Ahmet, Thomson, Kirsty J, Morris, Emma C, Hale, Geoff, Waldmann, Herman, Goldstone, Anthony H, Linch, David C, Mackinnon, Stephen

“…In patients with multiply relapsed Hodgkin's lymphoma allogeneic stem-cell transplantation has been limited by prohibitive non-relapse-related mortality rates…”
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Donor KIR genotype has a major influence on the rate of cytomegalovirus reactivation following T-cell replete stem cell transplantation by Cook, Mark, Briggs, David, Craddock, Charles, Mahendra, Premini, Milligan, Donald, Fegan, Christopher, Darbyshire, Philip, Lawson, Sarah, Boxall, Elizabeth, Moss, Paul

“…Reactivation of cytomegalovirus (CMV) is a common complication following allogeneic stem cell transplantation. Genetic determinants in the host and donor that…”
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Reduced‐intensity conditioning for allogeneic haematopoietic stem cell transplantation in relapsed and refractory Hodgkin lymphoma: impact of alemtuzumab and donor lymphocyte infusions on long‐term outcomes by Peggs, Karl S., Sureda, Anna, Qian, Wendi, Caballero, Dolores, Hunter, Ann, Urbano‐Ispizua, Alvaro, Cavet, James, Ribera, Josep M., Parker, Anne, Canales, Miguel, Mahendra, Premini, Garcia‐Conde, Javier, Milligan, Donald, Sanz, Guillermo, Thomson, Kirsty, Arranz, Reyes, Goldstone, Anthony H., Alvarez, Ivan, Linch, David C., Sierra, Jorge, Mackinnon, Stephen

“…Summary The introduction of reduced‐intensity conditioning (RIC) has enabled the role of allogeneic transplantation to be re‐evaluated in Hodgkin lymphoma…”
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The impact of donor KIR and patient HLA-C genotypes on outcome following HLA-identical sibling hematopoietic stem cell transplantation for myeloid leukemia by Cook, Mark A., Milligan, Donald W., Fegan, Christopher D., Darbyshire, Philip J., Mahendra, Premini, Craddock, Charles F., Moss, Paul A.H., Briggs, David C.

“…Killer immunoglobulin–like receptors (KIRs) regulate cell activity of natural killer (NK) cells and some T cells. The predominant ligand for inhibitory KIRs is…”
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The clinical outcome and toxicity of high‐dose chemotherapy and autologous stem cell transplantation in patients with myeloma or amyloid and severe renal impairment: a British society of blood and marrow transplantation study by Bird, Jennifer M., Fuge, Rhian, Sirohi, Bhawna, Apperley, Jane F., Hunter, Ann, Snowden, John, Mahendra, Premini, Milligan, Donald, Byrne, Jenny, Littlewood, Timothy, Fegan, Christopher, McQuaker, Grant, Pagliuca, Antonio, Johnson, Peter, Rahemtulla, Amin, Morris, Curly, Marks, David I.

“…Summary The outcome of high‐dose chemotherapy (HDT) was evaluated retrospectively in 27 patients with myeloma and four patients with AL amyloidosis with severe…”
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Dose‐intensified treatment of Burkitt lymphoma and B‐cell lymphoma unclassifiable, (with features intermediate between diffuse large B‐cell lymphoma and Burkitt lymphoma) in young adults (<50 years): A comparison of two adapted BFM protocols by Tauro, Sudhir, Cochrane, Lynda, Lauritzsen, Grete Fossum, Baker, Lee, Delabie, Jan, Roberts, Claudia, Mahendra, Premini, Holte, Harald

“…The chemotherapy dose‐intensity in two adapted German BFM paediatric protocols (BFM 90 and NHL 86) was compared in contemporaneously treated adults <50 years…”
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Reduced Intensity Allogeneic Tranplants Are Well Tolerated In Patients Over the Age of 60: Identification of Factors Predicting Overall Survival by Nikolousis, Emmanouil, Nagra, Sandeep, Ward, Janice, Dignan, Fiona L, Shaw, Bronwen E., Littlewood, Simon, Byrne, Jenny, Gilleece, Maria Helena, Tholouli, Eleni, Clark, Fiona, Cook, Mark, Mahendra, Premini, Cook, Gordon, Yin, John, Russell, Nigel H., Craddock, Charles

“…Abstract 2361 Reduced intensity allogeneic transplants represent a potentially curative therapy in older patients with haematological malignancies. However the…”
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Expansion of CD38+ Activated B Cells in Circulation as a Manifestation of Early Onset EBV Associated Post-Transplant Lymphoproliferative Disease by Chaganti, Sridhar, Nagra, Sandeep, Cook, Mark, Mahendra, Premini, Craddock, Charles, Osman, Husam, Hislop, Andrew, Freeman, Sylvie, Clark, Fiona

“…Epstein-Barr virus (EBV)-associated lymphoproliferative disease (LPD) is an uncommon but potentially fatal complication of allogeneic haematopoietic stem cell…”
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Intensifying Methotrexate (MTX) Dosage Reduces Treatment Failure in Adults with Burkitt or Burkitt-Like Leukaemia/Lymphoma (BL) Treated with an Adapted BFM Protocol by Tauro, Sudhir, Begum, Gulnaz, Lauritzsen, Grete Fossum, Delabie, Jan, Roberts, Claudia, Mahendra, Premini, Holte, Harald

“…The use of short-duration intensive combination chemotherapy protocols has improved survival in adults with Burkitt/Burkitt-like leukaemia and lymphoma (BL)…”
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Origin and subset distribution of peripheral blood dendritic cells in patients with chronic Graft-Versus-Host disease by CLARK, Fiona J, FREEMAN, Lisa, MOSS, Paul A, CHAKRAVERTY, Ronjon, DZIONEK, Andrzej, SCHMITZ, Jürgen, MCMULLAN, Dominic, SIMPSON, Peter, MASON, Joanne, MAHENDRA, Premini, CRADDOCK, Charles, GRIFFITHS, Mike

“…After allogeneic hematopoietic stem cell transplantation, donor T cells interact with an antigen-presenting cell environment that is distorted in number, level…”
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CD8+ T Cells Specific for Cancer-Testis Antigens Are Found in Many Patients with Multiple Myeloma and Correlate with Disease Burden by Goodyear, Oliver C., Piper, Karen, Arrazi, Julie, Khan, Naeem, Mahendra, Premini, Pratt, Guy, Moss, Paul

“…Proteins from the family known as ‘cancer-testis antigens' (CTAg) are expressed in some cases of multiple myeloma and subsets of acute myeloid leukaemia. CTAg…”
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